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Heparin Functionalized Injectable Cryogel with Rapid Shape-Recovery Property for Neovascularization
Kim, Inseon,Lee, Seunghun S.,Bae, Sunghoon,Lee, Hoyon,Hwang, Nathaniel S. American Chemical Society 2018 Biomacromolecules Vol.19 No.6
<P>Cryogel based scaffolds have high porosity with interconnected macropores that may provide cell compatible microenvironment. In addition, cryogel based scaffolds can be utilized in minimally invasive surgery due to its sponge-like properties, including rapid shape recovery and injectability. Herein, we developed an injectable cryogel by conjugating heparin to gelatin as a carrier for vascular endothelial growth factor (VEGF) and fibroblasts in hindlimb ischemic disease. Our gelatin/heparin cryogel showed gelatin concentration-dependent mechanical properties, swelling ratios, interconnected porosities, and elasticities. In addition, controlled release of VEGF led to effective angiogenic responses both <I>in vitro</I> and <I>in vivo</I>. Furthermore, its sponge-like properties enabled cryogels to be applied as an injectable carrier system for <I>in vivo</I> cells and growth factor delivery. Our heparin functionalized injectable cryogel facilitated the angiogenic potential by facilitating neovascularization in a hindlimb ischemia model.</P> [FIG OMISSION]</BR>
Mild Reduction of the Cancer Cell Surface as an Anti-invasion Treatment
Cha, Junghwa,Kim, Hyunbum,Hwang, Nathaniel S.,Kim, Pilnam American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.42
<P>Cancer cell invasion is the main reason for high mortality in patients with malignant cancers. There has been little improvement in cancer prognosis because of a high rate of infiltration. Therefore, successful treatment requires inhibition of cancer cell invasion. Here, we suggest a new approach to inhibit cancer cell invasion through mild reduction of cell surface proteins to expose free thiols. Through mild reduction, the cancer cell surfaces present free active thiols at the membranes, enhancing cell adhesion to extracellular matrix and decreasing motility. Collectively, we suggest cell surface modification as a new therapeutic approach to treat invading malignant cancers.</P> [FIG OMISSION]</BR>