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Miranda-Nantes, Carolina C.B.O.,Fonseca, Eveline A.I.,Zaia, Cassia T.B.V.,Dekker, Robert F.H.,Khaper, Neelam,Castro, Inar A.,Barbosa, Aneli M. The Korean Society of Mycology 2011 Mycobiology Vol.39 No.3
Botryosphaeran, a water-soluble exopolysaccharide of the ${\beta}-(1{\rightarrow}3;1{\rightarrow}6)$-D-glucan type that has been isolated from the culture medium of Botryosphaeria rhodina MAMB-05 grown in submerged fermentation using glucose as the sole carbon source, was previously demonstrated to be non-genotoxic in peripheral blood and bone marrow, and exhibited strong anticlastogenic activity. In the present study, the effects of botryosphaeran were investigated in streptozotocin-induced diabetic rats as well as in high-fat diet-fed hyperlipidemic Wistar rats. The plasma glucose level was reduced by 52% in the diabetic group of rats after administration of 12 mg botryosphaeran/kg body weight of the rats (b.w.)/day by gavage over 15 days. A reduction in the median ration intake was accompanied by an increase in the median body weight gain, as well as the efficiency of food conversion. These results demonstrate that botryosphaeran has protective effects by reducing the symptoms of cachexia in Diabetes mellitus. Botryosphaeran administered by gavage at a concentration of 12 mg botryosphaeran/kg b.w./day over 15 days also reduced the plasma levels of total cholesterol and low density lipoprotein-cholesterol by 18% and 27%, respectively, in hyperlipidemic rats. Based on these findings, we conclude that botryosphaeran possesses hypoglycemic and hypocholesterolemic properties in conditions of diabetes mellitus and hyperlipidemia, respectively, and may be used as an oral anti-diabetic agent.
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( Carolina C. B. O. Miranda Nantes ),( Eveline A. I. Fonseca ),( Cassia T. B. V. Zaia ),( Robert F. H. Dekker ),( Neelam Khaper ),( Inar A. Castro ),( Aneli M. Barbosa ) 한국균학회 2011 韓國菌學會誌 Vol.39 No.3
Botryosphaeran, a water-soluble exopolysaccharide of the β-(1 → 3;1 → 6)-D-glucan type that has been isolated from the culture medium of Botryosphaeria rhodina MAMB-05 grown in submerged fermentation using glucose as the sole carbon source, was previously demonstrated to be non-genotoxic in peripheral blood and bone marrow, and exhibited strong anticlastogenic activity. In the present study, the effects of botryosphaeran were investigated in streptozotocin-induced diabetic rats as well as in high-fat diet-fed hyperlipidemic Wistar rats. The plasma glucose level was reduced by 52% in the diabetic group of rats after administration of 12 mg botryosphaeran/kg body weight of the rats (b.w.)/day by gavage over 15 days. A reduction in the median ration intake was accompanied by an increase in the median body weight gain, as well as the efficiency of food conversion. These results demonstrate that botryosphaeran has protective effects by reducing the symptoms of cachexia in Diabetes mellitus. Botryosphaeran administered by gavage at a concentration of 12 mg botryosphaeran/kg b.w./ day over 15 days also reduced the plasma levels of total cholesterol and low density lipoprotein-cholesterol by 18% and 27%, respectively, in hyperlipidemic rats. Based on these findings, we conclude that botryosphaeran possesses hypoglycemic and hypocholesterolemic properties in conditions of diabetes mellitus and hyperlipidemia, respectively, and may be used as an oral anti-diabetic agent.
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Eddy Krueger,Eduardo Borba Neves,Percy Nohama,Eduardo Mendonça Scheeren,Guilherme Nunes Nogueira-Neto,Vera Lúcia da Silveira Nantes Button 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.1
Purpose In the present study, five FES profiles were compared in order to find the best combination of activeperiod and burst frequency that might artificially sustain muscle contraction for the longest time with the lowest knee joint variation. Methods Spinal cord injured volunteers (N=10) participated in this study. The frequency of each FES profile was 1 kHz with variable pulse active period (100 μs or 200 μs) and pulse inactive period (900 μs or 800 μs). The setup burst frequencies had either 50 Hz (3 ms active time and 17 ms rest time) or 70 Hz (3 ms active time and 11 ms rest time). Results The best results were obtained to FES profiles P2(burst frequency of 70 Hz and pulse active period of 100 μs),P3 (burst frequency of 50 Hz and pulse active period of 200 μs) and P4 (burst frequency of 70 Hz and pulse active period of 200 μs). Conclusions In order to maintain the SCIV´s knee angle with minimal variation, the best results occurred with the application of P2, P3 and P4 FES profiles.
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Qinwei Ding,Chun Li,Nanting Yu,Wenxing Hao,Jie Ji 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.3
The station keeping ability of a platform is the most fundamental guarantee to securing the dynamic stability of a Floating offshore wind turbine (FOWT) when being subjected to complex marine environment. These are usually evaluated in terms of rigid body dynamic response of a floating platform which supports whole FOWT. To investigate the dynamic response of array of FOWT, we put forward the concept of a large FOWT farm which consists of nine spar-type wind turbine array and meanwhile shares mooring line system by connecting those FOWT to one another. The whole FOWT is established based on OC3-Hywind spar buoy platform with NREL 5MW wind turbine. Considering effects of wind, wave and current loads, the dynamic response of the proposed FOWT was conducted based on FEM software ANSYS AQWA under both operational condition and survival condition. Besides, comparisons of dynamic response between the original single FOWT and the proposed FOWT farm were also made. Several interesting conclusions were gained through the investigation. For the original single FOWT, RAO in surge, heave and pitch are concentrated in low frequency, while the peak value of frequency is about 0.2 rad/s. In addition, FOWT (P1, P3, P7 and P9) located on the four vertices of 3×3 have higher sway motion which range from about -0.15 m~ 0.15 m, while sway motion of the rest can be neglected. With the worsening of environmental condition, surge motion of the original single FOWT increases significantly, while it’s not significant for the proposed FOWT farm. At the same time, statistic values of pitch motion of the proposed FOWT farm are quite close to those of the original single FOWT. While, under the survival condition, range of pitch motion of the proposed FOWT farm is significantly smaller than that of the original single FOWT. In all, the results verify the effectiveness of the proposed FOWT farm.
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