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R.B. Basavaraj,H. Nagabhushana,G.P. Darshan,B. Daruka Prasad,S.C. Sharma,K.N. Venkatachalaiah 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.51 No.-
Nano research offered new possibilities in surface-based science includes latentfingerprints and lipsprint detection on various surfaces. CdSiO3:Dy3+ nanopowders were fabricated via modifiedsonochemical method. Eccrine prints stained by optimized composition of prepared samples exhibitedhigh sensitivity, low background hindrance on various surfaces compared to traditionalfluorescentpowders. Surface morphologies were studied with different sonication influential parameters. Theestimated average crystallites size and band gap were found to be 22 nm and 5.37 eV respectively. Photometric CIE and CCT values were close to near ultraviolet light with CP of 95% for the preparedcompounds confirms their utility in thefield of optoelectronics
Boddu Prasanthi,Karamchety Surya Kameswari Shilpa,Mudili Nagabhushana Rao,Ponukumati Uma Devi 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.6
The primary objective of the present investigation was to formulate and evaluate fixed dose bilayer tablet of two antihyperglycemic agents with different mechanisms of action to improve glycemic control in patients with type 2 diabetes. A secondary objective is to ensure that metformin release should be less in stomach and completely released in alkaline pH within the stipulated hours. Hence, metformin hydrochloride (500 mg) sustained release (SR) layer was formulated using various release retardant polymers such as hydroxy propyl methyl cellulose, xanthan gum and sodium carboxy methyl cellulose in three different ratios of 1:0.3, 1:0.4 and 1:0.5, such that therapeutically effective levels can be maintained. Immediate release (IR) layer of pioglitazone hydrochloride (15 mg) was formulated using super disintegrant (crosspovidone) in four different ratios of 1:0.2, 1:0.4, 1:0.6 and 1:0.8. The formulated fixed dose bilayer tablets were subjected to various physiochemical evaluations like weight variation, friability, hardness, drug content, in vitro drug release kinetics and stability studies. The optimized formulation (F8) showed the maximum drug release up to 60 min in IR layer and up to 12 h in SR layer. Formulation F8 was found to be stable at room temperature for a period of 3 months. From the study it is evident that a promising bilayer tablet of pioglitazone hydrochloride and metformin hydrochloride can be developed using crosspovidone (disintegrant) and xanthan gum (release retardant polymer).