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Michel Canul-Chan,Jorge Chable-Naal,Rafael Rojas-Herrera,Alejandro Zepeda 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.2
A native microbial consortium capable of degrading hydrocarbons was employed as an inoculum source in a sequencing batch reactor (SBR) using molasses as a carbon source. The microbial biomass in the SBR was able to grow in the presence of molasses, degrading 88% of the reducing sugar. Moreover, the consortium produced in the SBR was capable of maintaining 75% of the capacity for biodegradation of oil with respect to the original capacity of the native microbial consortium. Monitoring of the microbial population structure was accomplished using PCR-DGGE. The results indicated that the microbial populations grown in molasses were stable during crude oil degradation, as judged by comparison to the population structure of the native microbial consortium. The results obtained demonstrated that molasses could be used as a carbon source to promote the growth of biomass with oildegrading capacity.
de la Parra, Miguel,Sanchez, Gerardo,Lopez, Jaime,Perez, Adrian,Naal, Norberto Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.6
Chondroblastomas are rare entities accounting for approximately 1% of all primary bone tumors. We describe a case of a 7-year-old girl with a giant chondroblastoma of the maxilla, treated with bilateral class III maxillectomy and reconstruction with a double-barreled and double skin paddle fibular free flap. We show evidence of an excellent aesthetic outcome at 6 months' follow up with no evidence of tumor recurrence.
Miguel de la Parra,Gerardo Sanchez,Jaime Lopez,Adrian Perez,Norberto Naal 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.6
Chondroblastomas are rare entities accounting for approximately 1% of all primary bone tumors. We describe a case of a 7-year-old girl with a giant chondroblastoma of the maxilla, treated with bilateral class III maxillectomy and reconstruction with a double-barreled and double skin paddle fibular free flap. We show evidence of an excellent aesthetic outcome at 6 months’ follow up with no evidence of tumor recurrence.
In situ screening of 3-arylcoumarin derivatives reveals new inhibitors of mast cell degranulation
Marcela de Souza Santos,Maria Perpe´tua Freire de Morais Del Lama,Laila Aparecida Deliberto,Fla´vio da Silva Emery,Moˆnica Tallarico Pupo,Rose Mary Zumstein Georgetto Naal 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
Due to the severity and high prevalence ofallergic diseases, there is growing interest in the developmentof inhibitors of such conditions. 3-Arylcoumarinderivatives emerge as promising compounds for thetreatment of allergic disorders, in particular due to theirclose structural similarity to flavonoids, whose anti-allergicactivity has been extensively reported. The aim of this workwas to perform a screening of a set of 3-arylcoumarins aspotential inhibitors of mast cell degranulation, a key eventfor the development of allergic reactions. For that purpose, itwas utilized a biosensor model based on mast cells, whosein vitro assay allows for such screening, in a high throughputfashion, and also permits bringing to attention some coumarinstructural features that are important for their biologicalactivity. The mast cell-based biosensor was shown todiscriminate, with high sensitivity and reproducibility,between coumarins that did not affect or caused differentdegrees of inhibition of degranulation. Among activecoumarins, some substituents could be accounted for theirinhibitory activity, such as the hydroxylation of positions 6and 20 of 3-phenylcoumarins, in addition to catechol, aminoand thiophene moieties. In summary, 3-arylcoumarins couldbe suggested as potential candidates for the developmentof new anti-allergic drugs.