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Stimulatory constituents of Eclipta prostrata on mouse osteoblast differentiation
Lee, Mi Kyeong,Ha, Na Ry,Yang, Hyekyung,Sung, Sang Hyun,Kim, Young Choong John Wiley Sons, Ltd. 2009 Phytotherapy research Vol.23 No.1
<P>One flavonoid, diosmetin (1), and two isoflavonoids, 3′-hydroxybiochanin A (2) and 3′-O-methylorobol (3), were isolated from the methanol extract of Eclipta prostrata L. by a bioactivity-guided fractionation technique using primary cultures of mouse osteoblasts as an in vitro assay system. All three compounds significantly increased osteoblast differentiation as assessed by the alkaline phosphatase activity. Copyright © 2008 John Wiley & Sons, Ltd.</P>