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Thirteen-Week Repeated-Dose Oral Toxicity of Licorice Root in F344 Rats
Sang-Bum Koh,Jae-Hwang Jeong,Mu-Yeb Seo,Jun-Yeon Lee,Dong-Seok Seo,Hak-Soo Bark,Myung-Hwa Kang,Dae-Yong Kim,Ha-Jung Sung 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1
The purpose of this study is to investigate a potential toxicity of licorice root (LR) in Fisher 344 rats through the 13-week repeated oral treatment. Healthy Fisher 344 rats were divided into five treatment groups (2,000, 571, 163, 47, and 13 ㎎/㎏) and one control group (vehicle) of 12 males and 12 females respectively. LR was orally administered by gavage to F344 rats once a day, 5 days per week for 13 weeks. During the test period, clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry, organ weight, histopathology, sperm count and sperm motility were evaluated. The relative liver weights were increased significantly in males of the 2,000 and 571 ㎎/㎏ groups. However, there was no histological evidence in the liver. The increased incidence of chronic nephropathy only appeared in the 2,000 ㎎/㎏ group of both male and female rats. There were no treatment-related effects on clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry and sperm count and motility in any treatment groups. Based on these results, no-observed adverse effect level (NOAEL) of LR was 571 ㎎/㎏ in F344 rats under the conditions of the present study.