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Lim, Ilhan,Park, Joon Yeun,Kang, Hye Jin,Hwang, Jae Pil,Lee, Seung Sook,Kim, Kyeong Min,Choi, Tae Hyun,Yang, Sung Hyun,Kim, Byung Il,Choi, Chang Woon,Lim, Sang Moo S. Karger AG 2013 Acta haematologica Vol.130 No.2
<P>Abstract</P><P><B><I>Aims:</I></B> It was the aim of this paper to identify prognostic factors in patients with relapsed or refractory B-cell non-Hodgkin's lymphomas, treated by radioimmunotherapy (RIT) with radioiodinated human/murine chimeric anti-CD20 monoclonal antibody rituximab (<SUP>131</SUP>I-rituximab). <B><I>Methods:</I></B> Twenty-four patients were enrolled prospectively and were treated with unlabeled rituximab 70 mg and a therapeutic activity (median 7.3 GBq) of <SUP>131</SUP>I-rituximab. Contrast-enhanced <SUP>18</SUP>F-FDG PET/CT scans were performed before and after 1 month of RIT. Tumor sizes and maximum standardized uptake values (SUV<SUB>max</SUB>) of scans were measured. <B><I>Results:</I></B> Four of the 24 patients survived. High SUV<SUB>max</SUB> in a pretreatment scan was found to be related to poorer overall survival (OS) and progression-free survival (p = 0.04 and 0.02, respectively). Furthermore, a large tumor size in a pretreatment scan was associated with poorer OS but not with progression-free survival (p < 0.01 and p = 0.07, respectively). By multivariate analyses, a high SUV<SUB>max</SUB>, a large tumor size in a pretreatment scan and diffuse large B-cell lymphoma histology were significantly associated with poorer OS [p = 0.04/hazard ratio (HR) = 3.54, p < 0.01/HR = 5.52, and p = 0.02/HR = 3.38, respectively). <B><I>Conclusion: </I></B>SUV<SUB>max</SUB> and tumor size determined by a pretreatment <SUP>18</SUP>F-FDG PET/CT result as significant predictors of OS in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma treated by RIT.</P><P>Copyright © 2013 S. Karger AG, Basel</P>
Oncologic outcomes after radical surgery for periampullary cancer in octogenarians
Sung Hyun Kim,Jae Uk Chong,Jin Hong Lim,Moon Jae Chung,Jeong Youp Park,Seung Min Bang,Seung Woo Park,Ho Kyung Hwang,Chang Moo Kang,Woo Jung Lee,Kyung Sik Kim 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.2
Backgrounds/Aims: Interest in treatments for elderly patients has increased with life expectancy, and various studies have reported on the safety and feasibility of radical surgery in elderly patients with cancer. Here, we investigated oncologic outcomes of periampullary cancer in octogenarians. Methods: We retrospectively reviewed medical records of 68 patients over 80 years of age who were diagnosed with periampullary cancer and were eligible for surgery; we analyzed overall survival (OS) and immediate postoperative complications and mortality. Results: There were no significant differences in mean age, disease type, oncologic features, comorbidities, or nutritional status between the patients who had surgery and those who did not. Five patients (20.0%) had major postoperative complications, but there was no immediate postoperative mortality. Patients who had surgery (n=25) had better OS (29.3 months; 95% confidence interval [CI]: 5.6-53.0) than did those who did not (n=43, OS: 7.6 months; 95% CI: 3.2-12.0 months; p <0.001). Similarly, patients with distal common bile duct cancer who underwent surgery had better OS than those who did not (surgery group: n=13, OS: 29.3 months, 95% CI: 8.9-49.7; non-surgery group: n=15, OS: 5.7 months, 95% CI: 4.2-7.2 months; p=0.002). Conclusions: Radical surgery for octogenarian patients with periampullary cancer is safe, feasible, and expected to result in better survival outcomes, especially for patients with common bile duct cancer.
REGENERATION AND TRANSFORMATION OF CHINESE CABBAGE : BRASSICA CAMPESTRIS L. ssp. PEKINENSIS
Lim, Chae-Oh,Choi, Young-Ju,Lee, Soo-In,Koo, Ja-Choon,Chun, Hyun-Jin,Gal, Sang-Wan,Heo, Won-Do,Cho, Moo-Je Plant Molecular Biology & Biotechnology Research C 1994 Plant molecular biology and biotechnology research Vol.1994 No.
This study was conducted to determine the more efficient regeneration and transformation system for Chinese cabbage genetic manipulation. Four-day-old hypocotyl segments of five cultivars grown on MS basal medium supplemented with B5 vitamins, 3% sucrose, 2.0mg/l BAP, 1.0mg/l NAA, in the presence of 5mg/l AgNO_(3) were not induceded shoots. The comperison of the ability of regeneration between five Chinese cabbage cultivars, shoot induction of Chinese cabbage species seemed to be cultivar-dependent. The best responder was ""Manjum"" variety of four days-old hypocotyl segments. Transformation performed the co-cultivation of hypocotyl segments with A. tumefaciens EHA101 containing the binary vector pGA663 with chloramphenicol acetyltransferase (CAT) as a repoter gene and neomycin phosphotransferase Ⅱ (NPT Ⅱ) as the selectable marker. Transformants were confirmed by the CAT enzyme activities which determined that the CAT gene had been transferred into the plant meterial and was being expressed at leaf and root.