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CrossFit-induced rhabdomyolysis: a case report
Moinuddin Nadaf,Jin Kyu Lee,Jae-Hyuk Yang 대한정형외과 스포츠의학회 2018 Arthroscopy and Orthopedic Sports Medicine Vol.5 No.1
CrossFit is a fitness regimen that has recently gained popularity in Korea. Although this training program has been shown to increase stamina and body fitness, it has also been associated with risk of exertional rhabdomyolysis. The severity of exertional rhabdomyolysis ranges from mild to life threatening situations, including acute renal failure, compartment syndrome, hepatic dysfunction, disseminated intravascular coagulation, cardiac arrhythmia, and even death. In this report, we describe a case of exertional rhabdomyolysis after CrossFit training. We have reviewed the current literature and suggested possible preventative measures during training to minimize injuries associated with CrossFit workouts.
Role of iron deficiency anemia in the propagation of beta thalssemia gene
Muhammad Usman,Moinuddin Moinuddin,Syed Azhar Ahmed 대한혈액학회 2011 Blood Research Vol.46 No.1
Background :The diagnostic criterion for beta thalassemia trait (BTT) is elevated Hb-A2 levels. Iron deficiency anemia (IDA) reduces the synthesis of Hb-A2, resulting in reduced Hb-A2 levels, so patients with co-pathological conditions BTT with IDA, may have a normal level of Hb-A2. Many socio-economic factors like unawareness, poor diagnostic facilities, and cost of molecular diagnosis (for screening purposes) result in interpretation of these subjects as normal. Methods :Venous blood samples from 200 unmarried females having a family history of thalassemia were collected, and basic hematological parameters, hemoglobin electrophoresis, and molecular analysis for beta thalassemia were done. Patients with IDA and patients with co-pathological conditions BTT and IDA were treated with oral iron. These subjects were then followed for a period of 20 weeks. Results :Of the 200 females, 34 were found to be anemic. Hemoglobin electrophoresis identified 16 of these patients as BTT. Molecular analysis of all patients confirmed this diagnosis, but identified 8 additional patients with BTT. Eight patients that were not detected with hemoglobin electrophoresis were found to have co-pathology of BTT with IDA. Conclusion :Patients with the co-pathological condition BTT with IDA may be interpreted as being normal, as they have normal Hb-A2 levels. These misdiagnosed subjects when marry with BTT have the potential to produce beta thalassemia major in offspring. This is one of the factors playing a major role in the propagation of beta thalassemia gene in Pakistani population, and become a serious hindrance for the thalassemia prevention program in Pakistan.
Muhammad Usman,Shafi Mohammad Khosa,Moinuddin Moinuddin,Hassan Osman Mehmood,Khansa Qamar 대한혈액학회 2015 Blood Research Vol.50 No.1
BackgroundThe present study is designed to evaluate the reliability and cost effectiveness of celluloseacetate Hb electrophoresis and high performance liquid chromatography (HPLC) in thedetermination of HbA2 levels. MethodsThe test population comprised 160 individuals divided into four groups: normal individuals, β-thalassemia trait (BTT) patients, iron deficiency anemia (IDA) patients, andco-morbid patients (BTT with IDA). HbA2 levels determined using cellulose acetate Hbelectrophoresis and HPLC were compared. ResultsHbA2 levels were found to be diagnostic for classical BTT using either method. In co-morbidcases, both techniques failed to diagnose all cases of BTT. The sensitivity, specificity,and Youden’s index for detection of the co-morbid condition was 69% and 66% for HPLCand cellulose acetate Hb electrophoresis, respectively. ConclusionThis study revealed that semi-automated cellulose acetate Hb electrophoresis is moresuitable for use in β-thalassemia prevention programs in low-income countries likePakistan. This technique is easily available, simple and cost effective.
Masidur Alam, M.,Naeem, M.,Idrees, M.,Khan, M. Masroor A.,Moinuddin, Moinuddin 한국작물학회 2012 Journal of crop science and biotechnology Vol.15 No.2
Exogenous application of plant growth regulators (PGRs) has vital impact on the growth and productivity of plants. Foliar application of selected PGRs, viz. indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), naphthalene acetic acid (NAA), 6-benzylaminopurine (BAP), kinetin (KIN), thidiazuron (TDZ), gibberellic acid ($GA_3$), salicylic acid (SA), homobrassinosteroids (HBR), and triacontanol (TRIA), were carried out in order to assess the effects on growth of two cultivars (Rosea and Alba) of Catharanthus roseus L. G. Don. The Rosea and Alba plants were sprayed with PGRs ($10^{-7}$ M) at 60 days after planting (DAP). Shoot and root lengths, plant fresh and dry weights, leaf-area index, total chlorophyll and carotenoids content, net photosynthetic rate, nitrate reductase and carbonic anhydrase activities, and leaf essential nutrients (N, P, and K) were analyzed at 150 DAP while yield attributes and total alkaloids of leaves and roots, contents of vincristine and vinblastine alkaloids were measured at 210 DAP. The results showed that HBR significantly improved most of the growth attributes. Application of HBR, KIN, and $GA_3$ resulted in the ameliorative effects on plant productivity, physiological and biochemical parameters as compared to the unsprayed (control) plants. The effect of TDZ was not significantly different than the control plants. $GA_3$ application significantly increased the vincristine content (7.3%) while TDZ exhibited reduced vincristine content. The effect of other PGR was insignificant towards vincristine and vinblastine contents. The response of Rosea toward exogenous PGRs application was better than Alba in terms of crop productivity, physiological and biochemical parameters, and alkaloid production.
고주현 ( Joo Hyun Go ),아흐메드 ( Moinuddin Ahmed ) 한국세계지역학회 2016 世界地域硏究論叢 Vol.34 No.4
그라민은행은 방글라데시 빈곤가정에 대한 무담보소액대출의 성공적인 모델을 발전 시켰다. 그러나 은행의 설립자인 유누스는 방글라데시 현 정권과의 정치적 갈등으로 미국으로터의 지원에도 불구하고 총재직에서 해임당했다. 이와 같은 사건에 주목하여 이 논문은 조합주의적 거버넌스 이론을 중심으로 그라민뱅크의 지속가능한 리더십의 가능성에 대해 분석하였다. 이를 위해 방글라데시 현지 및 주요 국제언론이 다루고 있는 그라민은행과 유누스 사건에 관한 기사들을 분석하고 특히 방글라데시 금융계 종사자들을 대상으로 전문가 인터뷰를 수행하였다. 현재 은행은 정부의 통제 하에 이사회가 운영되고 변동적인 임시 사무총장에 의해 관리가 이루어지는 등 그라민뱅크의 지속가능한 리더십의 가장 큰 위기 요인은 불안정한 리더십이라할 수 있다. The Grameen Bank advanced a successful model of extending credit to poor families in Bangladesh. The managing director, Dr. Yunus, was forced to step down and political conflict ensued between Yunus and the current government of Bangladesh. Even subsequent efforts by the US could not affect the leadership of Grameen Bank. This paper examines the sustainable leadership of Grameen Bank through the lens of corporate governance. The paper found several challenges for sustainable progress through a study of national and international media and interviews of local experts. Out of those challenges, the leadership problem was identified as a major concern for running this unique banking system smoothly, where Grameen Bank has been led by an acting managing director instead of a permanent director. In addition, Grameen Bank runs under a government-controlled board of members through the amendment of a 29-year-old law of governing, which caused Grameen Bank to face such challenges in its progress.
Ryan Jarrah,Sally El Sammak,Chiduziem Onyedimma,Abdul Karim Ghaith,F.M. Moinuddin,Archis R. Bhandarkar,Ahad Siddiqui,Nicolas Madigan,Mohamad Bydon 대한척추신경외과학회 2022 Neurospine Vol.19 No.2
Objective: To comprehensively characterize the utilization of alginate hydrogels as an alternative treatment modality for spinal cord injury (SCI). Methods: An extensive review of the published literature on studies using alginate hydrogels to treat SCI was performed. The review of the literature was performed using electronic databases such as PubMed, EMBASE, and OVID MEDLINE electronic databases. The keywords used were “alginate,” “spinal cord injury,” “biomaterial,” and “hydrogel.” Results: In the literature, we identified a total of 555 rat models that were treated with alginate scaffolds for regenerative biomarkers. Alginate hydrogels were found to be efficient and promising substrates for tissue engineering, drug delivery, neural regeneration, and cellbased therapies for SCI repair. With its ability to act as a pro-regenerative and antidegenerative agent, the alginate hydrogel has the potential to improve clinical outcomes. Conclusion: The emerging developments of alginate hydrogels as treatment modalities may support current and future tissue regenerative strategies for SCI.