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RISS 인기검색어
- 검색키워드
- 저자 : Mohanraj Palanisamy (검색결과 2 건)
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Mohanraj Palanisamy,Jasmina Khanam 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.3
To study the influence of temperature and pHon solubility and dissolution behavior of indomethacinsolid dispersions were prepared using several classes ofhydrophilic carriers. Investigations on dissolution of indomethacinin binary system are reported earlier. Howeverthe phase solubility and dissolution behavior at differentpH and temperature left void. The present investigationincludes: phase solubility study at various pH; preparationof solid dispersion by solvent evaporation, melting andkneading method; characterization of various blends bydissolution study, and solid state studies to ensure interactionof drug with carrier. The binding between drug andcarriers (PVP K30, bCD and PEG) was explained bythermodynamic parameters as calculated from phase solubilitystudy. Indomethacin in association with PVP K30showed very high apparent binding constant (Ka) andGibb’s free energy change (DG) in comparison to otherblends. The ternary system (drug:bCD:PVP K30, 1:5:1)showed better dissolution of about 80.97 and 99 % at pH7.2 after 5 and 30 min respectively. At higher proportion ofcarrier (1:9) in binary solid dispersion of drug and PVPK30, drug dissolution was 96.23 and 97.85 % after 5 and30 min respectively. This raised solubility of indomethacinwould be helpful in designing a dosage form.
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Mohanraj Palanisamy,Jasmina Khanam,Arunkumar Nagalingam,Nasimul Gani 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.10
The purpose of this study was to evolve experimental design, to prepare the sustained release microspheres loaded with prednisolone-hydroxypropyl-β-cyclodextrin complex, and develop a successful mathematical model to predict various characteristics of microspheres. Response surface methodology (RSM) has been employed to develop model equations that correlate process variables such as ethyl cellulose (EC, mg), hydroxypropyl methyl cellulose (HPMC,mg), stirring speed (rpm) and surfactant (%) with the response variables such as entrapment efficiency (%), particle size (μm) and release rate (%) of the drug. The adequacy of model equations is confirmed by ANOVA result. Results as predicted by model equations are in good agreement with that of experimental results. In vitro drug release shows that drug (93%) is released from a check point formulation (CPF 2) over the period of 24 h with a sustained release fashion with Quasi-Fickian kinetics. Surface morphology of microspheres varies with the experimental conditions as evidenced by scanning electron microscopy.
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