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RISS 인기검색어
- 검색키워드
- 저자 : Mohammad Taghi Goodarzi (검색결과 4 건)
- 무료
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Ahmadi-Motamayel, Fatemeh,Shahriari, Shahriar,Goodarzi, Mohammad Taghi,Moghimbeigi, Abbas,Jazaeri, Mina,Babaei, Parisa The Korean Academy of Conservative Dentistry 2013 Restorative Dentistry & Endodontics Vol.38 No.3
Objectives: Assessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis. Materials and Methods: Thirty-six patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13. Results: The level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males. Conclusions: There was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.
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Hamidreza Abdolsamadi,Fatemeh Ahmadi-Motamayel,Nasrin Rafieian,Mohammad Taghi Goodarzi,Javad Feradmal,Seyed-Mostafa Hoseyni,Mina Jazayeri,Zahrasadat Taghavi,Poorandokht Davoodi 전남대학교 의과학연구소 2014 전남의대학술지 Vol.50 No.2
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknownetiology. Many studies have implicated the protective role of antioxidants in suchdiseases. The aim of this study was to compare salivary total antioxidant capacity (TACand malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels inpatients with erosive OLP and healthy individuals. Thirty six patients with OLP (14males, 22 females) and 36 control subjects (15 males, 21 females), matched for age andsex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidantvitamin levels were measured in both case and control groups. The salivarylevel of MDA was significantly higher (p<0.001) in patients than in controls. In patientswith OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantlydecreased in patients with OLP (p<0.001). In addition, a positive correlationwas found between the decrease in the salivary amount of vitamin C and that in vitaminE in patients and controls. In addition to the lower salivary levels of antioxidant vitaminsand the lower TAC, the higher level of MDA in patients with OLP suggests thatfree radicals and the resulting oxidative damage may be important in the pathogenesisof OLP lesions.
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Vahid Khanjarsim,Jamshid Karimi,Iraj Khodadadi,Adel Mohammadalipour,Mohammad Taghi Goodarzi,Ghasem Solgi,Mohammad Hashemnia 전남대학교 의과학연구소 2017 전남의대학술지 Vol.53 No.2
Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the anti-fibrotic effects of Nilotinib via RAGE/HMGB1axis and antioxidant mechanisms. This experimental study was performed in the Hamadan University of Medical Sciences, Iran, from May 2015 to December 2016. Liver fibrosis was induced in Wistar male rats by CCL4. Rats were gavaged daily with Nilotinib (10 mg/kg). RAGE, HMGB1, TNF-a and TGF-b mRNA expression were evaluated by quantitative RT-PCR. TNF-a protein levels were measured using the immunoassay method. Thiol groups, carbonyl groups, nitric oxide levels and glutathione peroxidase activity were measured by spectrophotometric methods.The results showed that Nilotinib decreased TNF-a, TGF-b, RAGE and HMGB1 mRNA expression (p<0.001) in the liver tissues of the fibrosis group. Nilotinib also decreased carbonyl groups and nitric oxide levels and increased thiol groups and glutathione peroxidase activity in the fibrosis groups. The histopathological changes were found to be attenuated by Nilotinib. In conclusion, Nilotinib can improve liver fibrosis and open new mechanisms of the anti-fibrotic properties of Nilotinib.
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Mehdi Hatami,Massoud Saidijam,Reza Yadegarzari,Shiva Borzuei,Alireza Soltanian,Marzieh Safi Arian,Mohammad Taghi Goodarzi 전남대학교 의과학연구소 2016 전남의대학술지 Vol.52 No.3
Regulation of the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene plays an important role in controlling the metabolism of lipids and inflammatory processes. Therefore, it can be associated with the pathogenesis of metabolic syndrome (MetS). The purpose of this study was to determine the expression of this gene in peripheral blood mononuclear cells (PBMC) in patients with metabolic syndrome. Using real-time polymerase chain reaction (PCR), mRNA expression of PPAR-γ was found in PBMC from 37 subjects with MetS and 30 healthy controls. Serum levels of glucose and lipid profiles were measured. The total antioxidant capacity (TAC) was measured using the ferric reducing ability of plasma (FRAP) test. Malondialdehyde (MDA) was determined using a fluorimetric method. Total oxidant status (TOS) in serum was assayed according to oxidation of ferric to ferrous in the presence of methyl orange. Super oxide dismutase (SOD) activity was measured using a Randox kit. Expression of PPAR-γ gene was significantly increased in patients with MetS compared to the control subjects (p=0.002). There was no difference in serum levels of TAC, MDA and SOD between the two study groups, but a significant difference was observed in the TOS (p=0.03). Serum levels of triglycerides and glucose were significantly higher in subjects with MetS. According to the results of our study, an increase in the expression of PPAR-γ in subjects with MetS indicated a possible role of PPAR-γ in the pathogenesis of this disease.
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