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RISS 인기검색어
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- 저자 : Mohammad Saeid Farajzadeh (검색결과 2 건)
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Ali Khodam,Mohammad Saeid Farajzadeh,Mohsenali Shayanfar 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.85 No.3
Reliability-Based Design Optimization (RBDO) is an appropriate framework for obtaining optimal designs by taking uncertainties into account. Large-scale problems with implicit limit state functions and problems with discrete design variables are two significant challenges to traditional RBDO methods. To overcome these challenges, this paper proposes a hybrid method to perform RBDO of structures that links Firefly Algorithm (FA) as an optimization tool to advanced (finite element) reliability methods. Furthermore, the Genetic Algorithm (GA) and the FA are compared based on the design cost (objective function) they achieve. In the proposed method, Weighted Simulation Method (WSM) is utilized to assess reliability constraints in the RBDO problems with explicit limit state functions. WSM is selected to reduce computational costs. To performing RBDO of structures with finite element modeling and implicit limit state functions, a First-Order Reliability Method (FORM) based on the Direct Differentiation Method (DDM) is utilized. Four numerical examples are considered to assess the effectiveness of the proposed method. The findings illustrate that the proposed RBDO method is applicable and efficient for RBDO problems with discrete and continuous design variables and finite element modeling.
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Maryam Hakimi Parizi,Saeedeh Farajzadeh,Iraj Sharifi,Abbas Pardakhty,Mohammad Hossein Daie Parizi,Hamid Sharifi,Ehsan Salarkia,Saeid Hassanzadeh 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.4
In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with ben- zoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration meth- od and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmani- cidal activity against promastigote and amastigote, apoptosis and gene expression levels of free solution and niosomal- encapsulated tioxolone along with benzoxonium chloride. Span/Tween 60 niosome had good physical stability and high encapsulation efficiency (more than 97%). The release profile of the entrapped compound showed that a gradual release rate. The combination of niosomal forms on promastigote and amastigote were more effective than glucantime. Also, the niosomal form of this compound was significantly less toxic than glucantime (P ≤ 0.05). The flowcytometric analysis on niosomal form of drugs showed that higher number of early apoptotic event as the principal mode of action (89.13% in 200 μg/mL). Also, the niosomal compound increased the expression level of IL-12 and metacaspase genes and de- creased the expression level of the IL-10 gene, which further confirming the immunomodulatory role as the mechanism of action. We observed the synergistic effects of these 2 drugs that induced the apoptotic pathways and also up regulation of an immunomodulatory role against as the main mode of action. Also, niosomal form of this combination was safe and demonstrated strong anti-leishmaniasis effects highlights further therapeutic approaches against anthroponotic cutane- ous leishmaniasis in future planning.
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