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- 저자 : Mohammad Moradi-Shahrbabak (검색결과 1 건)
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Transcriptional regulatory network analysis of the over-expressed genes in adipose tissue
Mohammad Reza Bakhtiarizadeh,Esmaeil Ebrahimie,Mohammad Moradi-Shahrbabak 한국유전학회 2014 Genes & Genomics Vol.36 No.1
Adipose tissue plays important roles in wholebody energy homeostasis and is now known to be a veryimportant and active endocrine organ. The transcriptionalregulatory network of adipose tissue metabolism is complexand much yet to be known. To identify transcriptionalprofile in adipose tissue, expressed sequence tag (EST)analysis using Digital Differential Display (DDD) wasemployed. The results of EST analysis were re-evaluatedby microarray data using COXPRESdb (an availableexpression data repository). To uncover transcriptionalregulatory mechanisms which play key roles in the adiposetissue metabolism, transcriptional regulatory network analysiswas applied, using the promoter analysis and interactionnetwork toolset. Sixty-five transcripts were found tobe more frequent in adipose tissue in comparison to theother tissues. COXPRESdb result showed that 62 % of the identified over-expressed genes in adipose tissue by DDDhad expression level greater than 1 (in base 2 logarithm). Based on coincidence of regulatory sites, candidate TFswere identified including TFs that previously known to beinvolved in adipose tissue metabolism (SP1, KROX,STAT1, LRF, VDR, LXR, SRF and HIF1) and TFs, such asCKROX, ZF5, ETF, AP-2, AP-2alpha, PAX-5, SPZ1,RBPJ and CACD, that had not been recognized previously. This work yielded several TF candidates activating inadipose tissue metabolism. These findings open a newavenue for future research on promoter occupancy and TFperturbation.
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