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Parisa Jafari,Mohammad Barzegar-Jalali,Abolghasem Jouyban 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.4
Solubility of salicylic acid in binary mixtures of water and betaine/propylene glycol (Bet/PG, molar ratio of 1:5), betaine/ethylene glycol (Bet/EG, molar ratio of 1:3) or betaine/glycerol (Bet/Gly, molar ratio of 1:3) deep eutectic solvents (DESs) was investigated via the shake flask method at 293.15–313.15 K under atmospheric pressure (≈85 kPa). The results indicate that the solubility values are enhanced with mass fraction of each DES and temperature and DES containing PG is the best cosolvent. The Hansen solubility parameter (HSP) of salicylic acid, neat solvents of each DES and water was calculated and used to predict the solubility of drug in each neat solvent. The experimental solubility values were in good agreement with the ones predicted from HSPs. Three cosolvency models (Jouyban-Acree, Jouyban-Acree-van’t Hoff and the modified version of Jouyban-Acree-van’t Hoff) and two activity coefficient models (NRTL and UNIQUAC) were selected to correlate the solubility data. Based on the obtained percentage mean relative deviations (MRD%) for back-calculated data, all the investigated models show good correlation and validation. Additionally, investigation of the apparent thermodynamic analysis presented an endothermic and entropy-driven dissolution of salicylic acid in all cosolvent compositions including neat DESs and water.
Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery
Sara Salatin,Jaleh Barar,Mohammad Barzegar-Jalali,Khosro Adibkia,Mitra Alami Milani,Mitra Jelvehgari 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.9
Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.