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      저자 : Mohamed Wael Sabry (검색결과 1 건)
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        Polyamide 6/tallow modified clay nanofibrous mat coupled with hydrogels for potential topical/transdermal delivery of doxycycline hydrochloride

        Shehab-ElDin Amira Nagy,Sobh Rokaya Aly,Rabie Abdelgawad Mohamed,Mohamed Wael Sabry,Nasr Hanaa Elsayed 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.2

        Purpose Current innovations in pharmaceutical industries involve the design of functionalized materials for drug delivery applications. Hybrid-bilayer patches of electrospun polyamide 6/tallow modified clay nanocomposite fibers coupled with hydrogels comprising sodium alginate (NaAlg), polyvinyl alcohol (PVA), or a mixture of both were developed. Methods The hydrogel precursors were crosslinked either ionically using a CaCl2 solution or physically through repeated freezing–thawing cycles to avoid toxic crosslinking agents. Doxycycline hydrochloride was loaded either by adsorption or active loading methods. The hybrid bilayer patches were evaluated for their physicochemical and morphological properties. Furthermore, in vitro drug release studies in phosphate-buffered saline (PBS) (pH 7.4) and acetate buffer (pH 5.5) were performed, along with antimicrobial activity and toxicity tests. Results An increase in the NaAlg ratio caused a gradual decrease in the gel content while greatly increasing the swelling ability. Porous structures were also produced. The in-vitro drug release profiles and corresponding kinetics were mainly dependent on structural factors. An initial burst release was observed from the CaAlg nanofibers (approximately 61.5% ± 0.68% and 52% ± 1.22% of the drug was released during the first 2 h in PBS and acetate buffer, respectively), whereas a relatively slow release rate was achieved from the nanofibers of the physically crosslinked PVA or PVA/NaAlg. The antimicrobial test confirmed that the loaded drug retained its antimicrobial efficacy. The toxicity test using the “Microtox analyzer model 500” exhibited EC50 ≥ 100, indicating no toxic effect against the luminescent marine bacteria Vibrio fischeri. Conclusion The fabricated functionalized patches showed great potential for topical/transdermal drug delivery.

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