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RISS 인기검색어
- 검색키워드
- 저자 : Mohamad Reza Fouladivanda (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
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Nader Dehghani,Mohamad Reza Fouladivanda,Mohamed Amin Ghobadifar,Gelayol Safshekan-Esfahani,Armin Akbarzadeh 전남대학교 의과학연구소 2015 전남의대학술지 Vol.51 No.1
The current study aimed to determine the efficacy of probing with adjunctive mitomycinC (MMC) as a treatment for nasolacrimal duct obstruction (NLDO) in adults and tostudy the association of probing success with demographic and obstructioncharacteristics. This was a prospective, randomized, double-blind, placebo-controlledtrial including 140 patients (each with a unilateral NLDO) scheduled for nasolacrimalprobing who were randomly assigned to receive MMC (0.2 mg/ml, 70 patients; groupA) or placebo (normal saline, 70 patients; group B). Irrigation was carried out with 0.5cc of MMC (0.2 mg/mL) in the duct with a nasal pack for 10 minutes in group A. Patients’postprobing epiphora was evaluated at 2 weeks and 1, 3, 6, and 9 monthspostoperatively. Probing was judged to be a success if there was no or mild wateringfor at least 9 months after the procedure. There were no significant differences betweenthe two study groups in demographic characteristics or duration of the operation(p=0.062). The overall success rate of probing with MMC was 47/70 (67.1%), which wassignificantly higher than the success rate of the procedure with placebo (p=0.0027). When the sex of the patients was controlled for by logistic regression, a significant associationbetween the failure rate of probing and increasing age was found in cases andcontrols (p=0.004 vs. p=0.006, respectively). No significant side effects of probing withMMC were noted after 9 months of follow-up. Administering MMC in a dosage of 0.2mg/mL during nasolacrimal probing significantly increased the success rate of probing. The failure rate of probing increased with age. A low dose of MMC is cheap, safe, andeasily accessible; thus, it is recommended during nasolacrimal probing, especially inpatients who refuse dacryocystorhinostomy surgery.
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