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RISS 인기검색어
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- 저자 : Mishel, Sabrin (검색결과 3 건)
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Reza Noroozian,Gevorg Gharehpetian,Mehrdad Abedi,Mishel Mahmoodi 전력전자학회 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.1
This paper presents the modeling, control and simulation of an interconnection system (ICS) of cascaded distributed generation (DG) modules for both grid-tied and stand-alone operations. The overall configuration of the interconnection system is given. The interconnection system consists of a cascaded DC/DC boost converters and a DC/AC inverter. Detailed modeling of the interconnection system incorporating a cascaded architecture has not been considered in previous research. In this paper, suitable control systems for the cascaded architecture of power electronic converters in an interconnection system have been studied and modeled in detail. A novel control system for DC/DC boost converters is presented based on a droop voltage controller. Also, a novel control strategy for DC/AC inverters based on the average large signal model to control the aggregated DG modules under both grid-tied and stand-alone modes is demonstrated. Simulation results indicate the effectiveness of the proposed control systems.
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Noroozian, Reza,Gharehpetian, Gevorg,Abedi, Mehrdad,Mahmoodi, Mishel The Korean Institute of Power Electronics 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.1
This paper presents the modeling, control and simulation of an interconnection system (ICS) of cascaded distributed generation (DG) modules for both grid-tied and stand-alone operations. The overall configuration of the interconnection system is given. The interconnection system consists of a cascaded DC/DC boost converters and a DC/AC inverter. Detailed modeling of the interconnection system incorporating a cascaded architecture has not been considered in previous research. In this paper, suitable control systems for the cascaded architecture of power electronic converters in an interconnection system have been studied and modeled in detail. A novel control system for DC/DC boost converters is presented based on a droop voltage controller. Also, a novel control strategy for DC/AC inverters based on the average large signal model to control the aggregated DG modules under both grid-tied and stand-alone modes is demonstrated. Simulation results indicate the effectiveness of the proposed control systems.
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SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin
Chen, Jun,Zhong, Ming-Chao,Guo, Huaijian,Davidson, Dominique,Mishel, Sabrin,Lu, Yan,Rhee, Inmoo,Pé,rez-Quintero, Luis-Alberto,Zhang, Shaohua,Cruz-Munoz, Mario-Ernesto,Wu, Ning,Vinh, Donald C.,Si Nature Publishing Group 2017 Nature Vol. No.
<P>Cancer cells elude anti-tumour immunity through multiple mechanisms, including upregulated expression of ligands for inhibitory immune checkpoint receptors(1,2). Phagocytosis by macrophages plays a critical role in cancer control(3-6). Therapeutic blockade of signal regulatory protein (SIRP)-alpha, an inhibitory receptor on macrophages, or of its ligand CD47 expressed on tumour cells, improves tumour cell elimination in vitro and in vivo(7-10), suggesting that blockade of the SIRP alpha-CD47 checkpoint could be useful in treating human cancer(11-14). However, the prophagocytic receptor(s) responsible for tumour cell phagocytosis is(are) largely unknown. Here we find that macrophages are much more efficient at phagocytosis of haematopoietic tumour cells, compared with non-haematopoietic tumour cells, in response to SIRP alpha-CD47 blockade. Using a mouse lacking the signalling lymphocytic activation molecule (SLAM) family of homotypic haematopoietic cell-specific receptors, we determined that phagocytosis of haematopoietic tumour cells during SIRP alpha-CD47 blockade was strictly dependent on SLAM family receptors in vitro and in vivo. In both mouse and human cells, this function required a single SLAM family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets. In contrast to most SLAM receptor functions(15-17), SLAMF7-mediated phagocytosis was independent of signalling lymphocyte activation molecule-associated protein (SAP) adaptors. Instead, it depended on the ability of SLAMF7 to interact with integrin Mac-1 (refs 18-20) and utilize signals involving immunoreceptor tyrosine-based activation motifs(21,22). These findings elucidate the mechanism by which macrophages engulf and destroy haematopoietic tumour cells. They also reveal a novel SAP adaptor-independent function for a SLAM receptor. Lastly, they suggest that patients with tumours expressing SLAMF7 are more likely to respond to SIRP alpha-CD47 blockade therapy.</P>
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