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Hou, Xin-Heng,Huang, Yu-Min,Mi, Yuan-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer (LC). So far, several studies between MTHFR C677T polymorphism and LC provide controversial or inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 14 publications. Eligible studies were identified by searching the Pubmed, Embase, Web of Science and Google Scholar databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Results: Overall, no significant association was detected between the MTHFR C677T polymorphism and LC risk, the same as in race subgroup. However, in the stratified analysis by histological type, significantly increased non-small-cell lung cancer (NSCLC) risk was indicated (T-allele vs. C-allele: OR = 1.11, 95%CI = 1.03-1.19; TT vs. CC: OR = 1.24, 95%CI = 1.09-1.41; TC vs. CC: OR = 1.11, 95%CI = 1.03-1.20 and TT+TC vs. CC: OR = 1.09, 95%CI = 1.03-1.15). At the same time, ever-smokers who carried T-allele (TT+TC) had a 10% decreased LC risk compared with CC genotype carriers. Conclusions: Our study provided evidence that the MTHFR 677T null genotype may increase NSCLC risk, however, it may protect ever-smokers against LC risk. Future studies with large sample sizes are warranted to further evaluate this association in more detail.
Red green blue emissive lead sulfide quantum dots: heterogeneous synthesis and applications
Hou, Bo,Cho, Yuljae,Kim, Byung-Sung,Ahn, Docheon,Lee, Sanghyo,Park, Jong Bae,Lee, Young-Woo,Hong, John,Im, Hyunsik,Morris, Stephen M.,Sohn, Jung Inn,Cha, SeungNam,Kim, Jong Min Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.15
<P>Visible emission colloidal quantum dots (QDs) have shown promise in optical and optoelectronic applications. These QDs are typically composed of relatively expensive elements in the form of indium, cadmium, and gallium since alternative candidate materials exhibiting similar properties are yet to be realized. Herein, for the first time, we report red green blue (RGB) photoluminescences with quantum yields of 18% from earth-abundant lead sulfide (PbS) QDs. The visible emissive property is mainly attributed to a high degree of crystallinity even for the extremely small QD sizes (1-3 nm), which is realized by employing a heterogeneous reaction methodology at high growth temperatures (>170 °C). We demonstrate that the proposed heterogeneous synthetic method can be extended to the synthesis of other metal chalcogenide QDs, such as zinc sulfide and zinc selenide, which are promising for future industrial applications. More importantly, benefiting from the enlarged band gaps, the as-prepared PbS solar cells show an impressive open circuit voltage (∼0.8 V) beyond that reported to date.</P>
Hou, Xiangyu,Bai, Xupeng,Gou, Xiaoli,Zeng, Hang,Xia, Chen,Zhuang, Wei,Chen, Xinmeng,Zhao, Zhongxiang,Huang, Min,Jin, Jing Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatin-resistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3,4,5,5,7-Pentamethoxyflavone (PMF), a natural flavon extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
Min Wang,Zhixiang Hou 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.2
In view of the low pointing accuracy problem of the hanging wire weight control method adopted in current mechanical arm control, for the control of the mechanical arm, a mechanical intelligent arm position control method based on continuous trajectory point control is proposed to improve the control accuracy of mechanical intelligent arm. The kinematic behavior planning model of the mechanical arm in six degree of freedom motion space is constructed. The end-effect inverse kinematics decomposition method is used to obtain the vector set of mechanical arm joint rotation. The parametric self-tuning regulation is used to control parameters optimization. Continuous trajectory point control method is adopted to improve the accuracy of mechanical intelligent arm position change and achieve high-precision arm control. Simulation results show that six degree of freedom mechanical intelligent arm accuracy control has higher precision, minimized convergence error and higher robustness with this control method.
Hou, Bo,Sohn, Myungbeom,Lee, Young-Woo,Zhang, Jingchao,Sohn, Jung Inn,Kim, Hansu,Cha, SeungNam,Kim, Jong Min unknown 2019 Nano energy Vol.62 No.-
<P><B>Abstract</B></P> <P>Artificially grown superstructures from small building blocks is an intriguing subject in ‘bottom-up’ molecular science and nanotechnology. Although discrete nanoparticles with different morphologies and physicochemical properties are readily produced, assembly them into higher-order structure amenable to practical applications is still a considerable challenge. This report introduces a stepwise heterogeneous approach for coupling colloidal quantum dots (QDs) synthesis with self-organization to directly generate quantum chains (QCs). By using vulcanized sulfur precursors, QDs are interdigitated into microscale chainlike supracrystals associated with oleylamine and oleic acid as structure directing agents. The cooperative nature of the QD growth and assembly have been extended to fabricate binary (PbS) and ternary metal chalcogenides (CuInS<SUB>2</SUB>) QC superstructures over a range of length scales. In addition, enhanced ion and charge transfer performance have been demonstrated which are determined to originate from the minimum interparticle distance and nearly bare nanocrystal surface. The process reported here is general and can be readily extended to the production of many other metal chalcogenide QD superstructures for energy storage applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new methodology for chemical synthesis self-organized quantum chain supracrystals. </LI> <LI> Binary and ternary metal chalcogenides quantum chain superstructures have been demonstrated over a range of length scales. </LI> <LI> Enhanced electrochemical capacity and durability via preserved nanograin boundaries and long-range ordered configuration. </LI> <LI> Demonstrate exceptional charge and ion transport properties in DFT simulations and lithium-ion batteries. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Cognitive map or medium materiality? Reading on paper and screen
Hou, Jinghui,Rashid, Justin,Lee, Kwan Min Pergamon 2017 Computers in human behavior Vol. No.
<P><B>Abstract</B></P> <P>The present study examined two common mechanisms that are used to explain why reading on an electronic screen versus paper result in different reading outcomes: The Cognitive Map Mechanism and the Medium Materiality Mechanism. A laboratory experiment (N = 45), was conducted using a three-group comparison design (paper book vs. digital equivalent vs. digital disrupted view). Our hypotheses that were based on the cognitive map mechanism were largely supported. On the other hand, our hypotheses following the medium materiality mechanism were not sufficiently evidenced. Specifically, our results showed that the paper book was similar to its digital equivalent, and both were better than the digital disrupted view in terms of reading comprehension, feelings of fatigue, and psychological immersion. The findings implied that it is not the materiality of the presentation medium that influences reading outcomes, rather it is the extent to which the text presentation facilitates, or impedes, the reader's ability to construct a cognitive map that influences the reading process. Implications for future research and practice are discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We tested the difference between reading on an electronic screen versus paper. </LI> <LI> Our findings supported the cognitive map mechanism. </LI> <LI> Our findings failed to show evidence for the medium materiality mechanism. </LI> <LI> Readers' ability to construct a cognitive map of text affected reading outcomes. </LI> </UL> </P>
Hou, Jin-Gang,Jeon, Byeong-Min,Yun, Yee-Jin,Cui, Chang-Hao,Kim, Sun-Chang MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.5
<P>The anthracycline antibiotic doxorubicin is commonly used antineoplastic drug in breast cancer treatment. Like most chemotherapy, doxorubicin does not selectively target tumorigenic cells with high proliferation rate and often causes serve side effects. In the present study, we demonstrated the cellular senescence and senescence associated secretory phenotype (SASP) of both breast tumor cell MDA-MB-231 and normal epithelial cell MCF-10A induced by clinical dose of doxorubicin (100 nM). Senescence was confirmed by flattened morphology, increased level of beta galactose, accumulating contents of lysosome and mitochondrial, and elevated expression of p16 and p21 proteins. Similarly, SASP was identified by highly secreted proteins IL-6, IL-8, GRO, GM-CSF, MCP-1, and MMP1 by antibody array assay. Reciprocal experiments, determined by cell proliferation and apoptosis assays and cell migration and cell invasion, indicated that SASP of MDA-MB-231 cell induces growth arrest of MCF-10A, whereas SASP of MCF-10A significantly stimulates the proliferation of MDA-MB-231. Interestingly, SASP from both cells powerfully promotes the cell migration and cell invasion of MDA-MB-231 cells. Treatment with the natural product ginsenoside Rh2 does not prevent cellular senescence or exert senolytic. However, SASP from senescent cells treated with Rh2 greatly attenuated the above-mentioned bystander effect. Altogether, Rh2 is a potential candidate to ameliorate this unwanted chemotherapy-induced senescence bystander effect. </P>