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RISS 인기검색어
- 검색키워드
- 저자 : Mingde Ding (검색결과 2 건)
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Mingde Ding,Xiuling Liang,Xianfang Xin,Dongmei Qi,Chengyan Fu 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2
Purpose: This study aimed to investigate the effects of PIK3CA on the sensitivity of acute B lymphocytic leukemia cells (Nalm-6cells) to chemotherapy drugs. Materials and Methods: Children’s normal B lymphocytes and Nalm-6 cells were cultured. Nalm-6 cells were transfected withPIK3CA siRNA (siPIK3CA group) or its negative control (PIK3CA-Control group). Normal Nalm-6 cells were named Mock group. Nalm-6 cells transfected by PIK3CA siRNA were treated with Akt inhibitor (siPIK3CA+Akti-1/2 group). mRNA and protein expressionwas detected by qRT-PCR and Western blot. Proliferation and sensitivity to chemotherapeutic drugs was detected by MTTassay. Cell cycle and apoptosis was explored by low cytometry. Transwell assay was performed to test invasion. Results: PIK3CA mRNA (p=0.008) and protein (p=0.006) expression was higher in Nalm-6 cells than that in normal B lymphocytes. Compared with the Mock group and PIK3CA-Control group, Nalm-6 cells of the siPIK3CA group had lower OD495 values (allp<0.05) and invasion cell numbers (p=0.03 and p=0.025), as well as a higher proportion of G0/G1 phase cells (p=0.020 and p=0.022), percentage of apoptosis (p=0.016 and p=0.022), and inhibition rate (all p<0.05). pAkt expression in the siPIK3CA group (p=0.026 and p=0.031) and siPIK3CA+Akti-1/2 group (p=0.019 and p=0.023) was lower than that in the Mock group. Conclusion: PIK3CA silencing inhibited Nalm-6 cell proliferation and invasion, and promoted their apoptosis and sensitivity tochemotherapeutic drugs, potentially through regulation of the PI3K/AKT signaling pathway.
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ULTRA-NARROW NEGATIVE FLARE FRONT OBSERVED IN HELIUM-10830 Å USING THE 1.6 m NEW SOLAR TELESCOPE
Xu, Yan,Cao, Wenda,Ding, Mingde,Kleint, Lucia,Su, Jiangtao,Liu, Chang,Ji, Haisheng,Chae, Jongchul,Jing, Ju,Cho, Kyuhyoun,Cho, Kyungsuk,Gary, Dale,Wang, Haimin American Astronomical Society 2016 The Astrophysical journal Vol.819 No.2
<P>Solar flares are sudden flashes of brightness on the Sun and are often associated with coronal mass ejections and solar energetic particles that have adverse effects on the near-Earth environment. By definition, flares are usually referred to as bright features resulting from excess emission. Using the newly commissioned 1.6. m New Solar Telescope at Big Bear Solar Observatory, we show a striking 'negative' flare with a narrow but unambiguous 'dark' moving front observed in He I 10830 angstrom, which is as narrow as 340 km and is associated with distinct spectral characteristics in Ha and Mg II lines. Theoretically, such negative contrast in He I 10830 angstrom can be produced under special circumstances by nonthermal electron collisions or photoionization followed by recombination. Our discovery, made possible due to unprecedented spatial resolution, confirms the presence of the required plasma conditions and provides unique information in understanding the energy release and radiative transfer in astronomical objects.</P>
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