Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

Wang, Min,Wu, Wei-Dong,Chen, Gui-Ming,Chou, Sheng-Long,Dai, Xue-Ming,Xu, Jun-Ming,Peng, Zhi-Hai Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18

Background: Central lymph node metastasis(CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of this study was to define the pathohistologic risk grading based on surgical outcomes. Materials and Methods: Statistical analysis was performed to figure out the optimal cut-off values of size in preoperative ultrasound images for defining the risk of CLNM in papillary thyroid microcarcinoma. Receiver operating characteristic curves (ROC) studies were carried out to determine the cutoff value(s) for the predictor(s). All the patients were divided into two groups according to the above size and the clinic-pathological and immunohistochemical parameters were compared to determine the significance of findings. Results: The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. Significant differences were observed on the multifocality, extrathyroidal extension and central lymph node metastasis between two groups which were divided according to the tumor size by the cutoff values. Patients in two groups showed different positive rate and intensity of Ki67. Conclusions: The size of PTMC in ultrasound images are helpful to predict the aggressiveness of the tumors, it could be an easy predictor for PTMC prognosis and assist us to choose treatment.

Intense X-ray induced formation of silver nanoparticles stabilized by biocompatible polymers

Wang, Chang-Hai,Liu, Chi-Jen,Wang, Cheng-Liang,Chien, Chia-Chi,Hwu, Y.,Liu, Ru-Shi,Yang, Chung-Shi,Je, Jung-Ho,Lin, Hong-Ming,Margaritondo, G. Springer-Verlag 2009 Applied physics. A, Materials science & processing Vol.97 No.2

ppGalNAc T1 as a Potential Novel Marker for Human Bladder Cancer

Ding, Ming-Xia,Wang, Hai-Feng,Wang, Jian-Song,Zhan, Hui,Zuo, Yi-Gang,Yang, De-Lin,Liu, Jing-Yu,Wang, Wei,Ke, Chang-Xing,Yan, Ru-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Objectives: To investigate the effect of glycopeptide-preferring polypeptide GalNAc transferase 1 (ppGalNAc T1 ) targeted RNA interference (RNAi) on the growth and migration of human bladder carcinoma EJ cells in vitro and in vivo. Methods: DNA microarray assays were performed to determine ppGalNAc Ts(ppGalNAc T1-9) expression in human bladder cancer and normal bladder tissues. We transfected the EJ bladder cancer cell line with well-designed ppGalNAc T1 siRNA. Boyden chamber and Wound healing assays were used to investigate changes of shppGalNAc T1-EJ cell migration. Proliferation of shppGalNAc T1-EJ cells in vitro was assessed using [3H]-thymidine incorporation assay and soft agar colony formation assays. Subcutaneous bladder tumors in BALB/c nude mice were induced by inoculation of shppGalNAc T1-EJ cells and after inoculation diameters of tumors were measured every 5 days to determine gross tumor volumes. Results: ppGalNAc T1 mRNA in bladder cancer tissues was 11.2-fold higher than in normal bladder tissues. When ppGalNAc T1 expression in EJ cells was knocked down through transfection by pSUPER-shppGalNAc T1 vector, markedly reduced incorporation of [3H]-thymidine into DNA of EJ cells was observed at all time points compared with the empty vector transfected control cells. However, ppGalNAc T1 knockdown did not significantly inhibited cell migration (only 12.3%). Silenced ppGalNAc T1 expression significantly inhibited subcutaneous tumor growth compared with the control groups injected with empty vector transfected control cells. At the end of observation course (40 days), the inhibitory rate of cancerous growth for ppGalNAc T1 knockdown was 52.5%. Conclusion: ppGalNAc T1 might be a potential novel marker for human bladder cancer. Although ppGalNAc T1 knockdown caused no remarkable change in cell migration, silenced expression significantly inhibited proliferation and tumor growth of the bladder cancer EJ cell line.

Measurement of neutron cross sections and resonance parameters of ¹⁶⁹Tm below 100 eV

Wen-Ming, Wang,Xia, Li,Zhi-Xiang, Zhao,Zu-Ying, Zhou,Hong-Wei, Yu,Hai-Cheng, Wu,Yi-Xiang, Wei,Wang, T. F.,Kim, G. N.,Lee, M. W.,Kim, K. S.,Cho, M. H.,Ko, I. S.,Namkung, W. science press 2010 Chinese physics. C Vol.34 No.2

<P>The neutron total cross-sections of thulium (<SUP>169</SUP>Tm) were measured in the neutron energy region from 0.01 eV to 100 eV by using the time-of-flight method at the Pohang Neutron Facility, which consists of an electron linac, a water-cooled tantalum target with a water moderator, and a 12 m time of flight path. Two thulium plates with different thicknesses were used for the neutron transmission measurement. The background level was determined by using a notch-filter of Co, In, and Cd sheets. The present measurement was compared with the previous ones, and a new set of resonance parameters of <SUP>169</SUP>Tm isotope was obtained from the transmission rate by using the SAMMY code, with a comparison with the recommended parameters by Mughabghab.</P>

Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers

Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11

Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.

An Iris Localization Algorithm based on Geometric Features of the Circle

Ming Fei Wang,RuiYun Xie,BenZhai Hai 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.7

An iris localization algorithm with the fast speed is proposed based on geometric features of the circle combing coarse localization with fine localization to avoid the problem of the slow speed of the classical iris localization algorithm. First, the row and column scanning method is employed to find four strings in the pupil. Four couples of tangency points are located by using the perpendicular bisector of strings and the threshold of the pupil boundary. The mean value of the coordinate parameters of the tangency points is regarded as the parameters for inner edge rough localization parameters. Then the calculus method is used for precise localization of the inner edge. The priori knowledge of the close distance between inner and outer edge centers of the circle is used to narrow the search range of the calculus method localizing outside edge, to significantly improving the speed of iris localization. The experimental results show that the proposed algorithm can improve the speed of iris localization with the high localizing accuracy.

Effect of Ausforming on the Stability of Retained Austenite in a C-Mn-Si Bainitic Steel

Hai-jiang Hu,Guang Xu,Li Wang,Ming-xing Zhou,Zheng-liang Xue 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.5

The effect of ausforming on the stability of retained austenite in a C-Mn-Si bainitic steel was investigated through metallography, X-ray diffraction and dilatometry. The geometrical relationships of the amount of bainite transformation and the volume fractions of retained austenite with deformation strains were studied. The results show that the degree of promotion of small strains on bainite transformation is nonlinear because of the dual effects of accelerated nucleation and retarded growth caused by ausforming. The transformed bainite fraction first increased and then decreased with increased small strains. It indicates that there is a maximum degree of the promotional function corresponding to a certain small strain at low temperature. Although small strains promote bainite transformation, a larger quantity of retained austenite exists at room temperature due to the suppressed martensite transformation during the cooling process after bainite transformation. The carbon content in retained austenite increases with the amount of baintie transformation, which contributes to the stability of austenite. Compared with the stabilizing effect due to carbon enrichment, mechanical stabilization caused by ausforming has a decisive effect on determining the volume fraction of retained austenite after isothermal bainite transformation.

Feedback Linearization Control of Chaos Synchronization in Coupled Map-Based Neurons Under External Electrical Stimulation

Hai-Tao Yu,Yiu Kwong Wong,Wai Lok Chan,Kai Ming Tsang,Jiang Wang 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.5

In this paper, the dynamics of single and two electrically coupled map-based neurons under external electrical stimulation is studied. In order to realize the synchronization of two chaotic spiking neurons, a controller based on the idea of feedback linearization is proposed. The simulation results demonstrate the effectiveness of this developed control method. An important feature of the feedback control is that the amplitude of control signal tends to zero as soon as the synchronization is achieved.

Epidemic spreading on complex networks with general degree and weight distributions.

Wang, Wei,Tang, Ming,Zhang, Hai-Feng,Gao, Hui,Do, Younghae,Liu, Zong-Hua Published by the American Physical Society through 2014 Physical review. E, Statistical, nonlinear, and so Vol.90 No.4

<P>The spread of disease on complex networks has attracted wide attention in the physics community. Recent works have demonstrated that heterogeneous degree and weight distributions have a significant influence on the epidemic dynamics. In this study, a novel edge-weight-based compartmental approach is developed to estimate the epidemic threshold and epidemic size (final infected density) on networks with general degree and weight distributions, and a remarkable agreement with numerics is obtained. Even in complex networks with the strong heterogeneous degree and weight distributions, this approach is used. We then propose an edge-weight-based removal strategy with different biases and find that such a strategy can effectively control the spread of epidemic when the highly weighted edges are preferentially removed, especially when the weight distribution of a network is extremely heterogenous. The theoretical results from the suggested method can accurately predict the above removal effectiveness.</P>

Comprehensive Analysis of the Dilatation During Bainitic Transformation Under Stress

Ming-xing Zhou,Guang Xu,Li Wang,Zheng-liang Xue,Hai-jiang Hu 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.6

The thermal simulation experiments on bainitic transformation were conducted on Gleeble 3800. The microstructures of specimens were examined by scanning electron microscopy. The main purpose is to investigate the relationship between the dilatation of specimens and bainitic transformation under stress. Results show that the radial strain cannot represent the real amount of bainitic transformation under stress because the radial strain contains both shear and dilatational components of invariant plane strain. In this case, the volume strain, which eliminates the influence of the shear components, should be used to analyze the amount of bainitic transformation under stress. In addition, the radial strain should not be used for the investigation of the kinetics of bainitic transformation under stress. For bainitic transformation without stress, the radial strain of the specimen can represent the amount of bainite, and can be used for the analysis of the kinetics of bainitic transformation; so it is not necessary to measure the volume strain. The present study clarifies the relationship between dilatation and the bainitic transformation under stress, and provides a useful reference to the analysis of bainitic transformation under stress.