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- 저자 : Miaomiao Jiang (검색결과 3 건)
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Li Miaomiao,Cai Wenrong,Jiang Lihua,Li Junyao,Li Shan,Tang Tongtong,Kong Yong 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.12
Mesoporous manganese dioxide (mMnO 2 ) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX‐loaded mMnO 2 (mMnO 2 ‐MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO 2 . Both low pH and glutathione (GSH) can result in the degradation of mMnO 2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO 2 ‐MTX‐PDA can be triggered by low pH and GSH. Near‐infrared (NIR) light‐responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO 2 ‐MTX‐PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light tri‐responsive drug‐controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1. Mesoporous manganese dioxide (mMnO2) was first synthesized for the loading of methotrexate (MTX), and then dopamine was in situ polymerized on the surface of the MTX-loaded mMnO2 (mMnO2-MTX) in an alkaline solution to encapsulate the drug in the mesopores of mMnO2. Both low pH and glutathione (GSH) can result in the degradation of mMnO2 and poly(dopamine) (PDA), and thus the delivery of MTX from the mMnO2-MTX-PDA can be triggered by low pH and GSH. Near-infrared (NIR) light-responsive delivery of MTX can be achieved owing to the outstanding photothermal conversion capability of PDA; on the other hand, the mMnO2-MTX-PDA can be utilized for photothermal therapy under the irradiation of NIR light due to the elevated temperature. The results of cytotoxicity test demonstrate that the pH, GSH, and NIR light triresponsive drug-controlled delivery system has excellent biocompatibility, while exhibits pronounced growth inhibition against murine breast tumor cell line 4T1.
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Jingyu Ni,Zhihao Liu,Miaomiao Jiang,Lan Li,Jie Deng,Xiaodan Wang,Jing Su,Yan Zhu,Feng He,Jingyuan Mao,Xiumei Gao,Guanwei Fan 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2
Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular mechanisms involved. Methods: The effects of ginsenoside Rg3 on heart and mitochondrial function were investigated by treating TAC-induced heart failure in mice. The mechanism of ginsenoside Rg3 for improving heart and mitochondrial function in mice with heart failure was predicted through integrative analysis of the proteome and plasma metabolome. Glucose uptake and myocardial insulin sensitivity were evaluated using micro-positron emission tomography. The effect of ginsenoside Rg3 on myocardial insulin sensitivity was clarified by combining in vivo animal experiments and in vitro cell experiments. Results: Treatment of TAC-induced mouse models with ginsenoside Rg3 significantly improved heart function and protected mitochondrial structure and function. Fusion of metabolomics, proteomics, and targeted metabolomics data showed that Rg3 regulated the glycolysis process, and Rg3 not only regulated glucose uptake but also improve myocardial insulin resistance. The molecular mechanism of ginsenoside Rg3 regulation of glucose metabolism was determined by exploring the interaction pathways of AMPK, insulin resistance, and glucose metabolism. The effect of ginsenoside Rg3 on the promotion of glucose uptake in IR-H9c2 cells by AMPK activation was dependent on the insulin signaling pathway. Conclusions: Ginsenoside Rg3 modulates glucose metabolism and significantly ameliorates insulin resistance through activation of the AMPK pathway.
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