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Uncu, Dogan,Bayoglu, Ibrahim Vedat,Arslan, Ulku Yalcintas,Kucukoner, Mehmet,Artac, Mehmet,Koca, Dogan,Oguz, Arzu,Demirci, Umut,Arpaci, Erkan,Dogan, Mutlu,Kucukzeybek, Yuksel,Turker, Ibrahim,Isikdogan, Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.
Mehmet Siddik Yildiz,Mehmet Emin Adin,Ahmet Dogan,Ibrahim Halil Koparan 대한위암학회 2016 Journal of gastric cancer Vol.16 No.1
Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal system and comprise only 1% to 3% of all gastrointestinal tract tumors, with the majority of them arising in the stomach. In this report, we present the unique findings of a case of gastroduodenal intussusception caused by an underlying gastric GIST and complicated with severe acute pancreatitis.
Yildiz, Mehmet Siddik,Dogan, Ahmet,Koparan, Ibrahim Halil,Adin, Mehmet Emin The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.1
Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal system and comprise only 1% to 3% of all gastrointestinal tract tumors, with the majority of them arising in the stomach. In this report, we present the unique findings of a case of gastroduodenal intussusception caused by an underlying gastric GIST and complicated with severe acute pancreatitis.
Recurrence Risk and Prognostic Parameters in Stage I Rectal Cancers
Cihan, Sener,Kucukoner, Mehmet,Ozdemir, Nuriye,Dane, Faysal,Sendur, Mehmet Ali Nahit,Yazilitas, Dogan,Urakci, Zuhat,Durnali, Ayse,Yuksel, Sinemis,Aksoy, Sercan,Colak, Dilsen,Seker, Mehmet Metin,Taskoy Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: The standard therapy for stage I rectum cancer is surgical resection. Currently, there is no strong evidence to suggest that any type of adjuvant therapy is beneficial. The risks of local relapse and distant metastasis are higher in rectal tumors. Therefore, while there is no clearly defined absolute indication for adjuvant therapy in lymph node negative colon cancers, rectum tumors that are T3N0 and higher require adjuvant treatment. Due to the more aggressive nature of rectal cancers, we explored the clinical and pathologic factors that could predict the risk of relapse in Stage I (T1-T2) disease and whether there was any progression-free survival benefit to adjuvant therapy. Materials and Methods: This multicenter study was carried out by the Anatolian Society of Medical Oncology. A total of 178 patients with rectal cancers who underwent curative surgery between January 1994 and August 2012 in 13 centers were included in the study. Patient demographics, including survival data and tumor characteristics were obtained from medical charts. Results: The median age was 58 years (range 26-85 years). Most tumors were well or moderately differentiated. For adjuvant treatment, 13 patients (7.3%) received radiotherapy alone, 12 patients (6.7%) received chemotherapy alone and 15 patients (8.4%) were given chemoradiotherapy. Median follow up was 29 months (3-225 months). Some 42 patients (23.6%) had relapse during follow up; 30 with local recurrence (71.4%) whereas 12 (28.6%) were distant metastases. Among the patients, 5-year DFS was 64% and OS was 82%. Mucinous histology and receiving adjuvant therapy were found to have statistically insignificant correlations with relapse and survival. Conclusions: In our retrospective analysis, approximately one quarter of patients exhibited either local or systemic relapse. The rates of relapse were slightly higher in the patients who had no adjuvant therapy. There may thus be a role for adjuvant therapy in high-risk stage I rectal tumors.
The frog appliance for upper molar distalization : a case report
Mehmet Bayram,Metin Nur,Dogan Kilkis 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.1
The purpose of this article was to evaluate the effects of a new upper molar distalization system, the Frog Appliance, on dentofacial structures in a Class II, division 1 patient. An 11-year-old girl was referred to our clinic for orthodontic treatment. She had a mild skeletal Class II malocclusion with Class II molar and canine relationship on both sides. The treatment plan included distalization of the upper first molars bilaterally followed by full fixed appliance therapy. For the upper molar distalization, a new system, the Frog Appliance, was constructed and applied. Lateral cephalometric radiographs were used to evaluate the treatment results. Distalization of the upper first molars was achieved in four months successfully, and Class I molar relationship was obtained. Total treatment time was 16 months. According to the results of the cephalometric evaluation, a nearly bodily distal molar movement with a slight anchorage loss was attained. In conclusion, the Frog Appliance was found to be a simple, effective, non-invasive, and compliance-free intraoral distalization appliance for achieving bilateral molar distalization. 본고의 목적은 2급 1류 치열안면 구조를 가지는 한 환자에 적용된 새로이 고안된 상악 대구치 원심 이동 장치인 Frog appliance의 효과를 평가하기 위함이다. 11세의 여자 환자가 교정 치료를 위해 본 진료실로 의뢰되었다. 환자는 미약한 2급 골격관계와 2급의 대구치 및 견치 관계를 양측 모두에서 보이고 있었다. 고정성 장치 치료를 통해 양측 상악 제1대구치를 원심 이동시키는 방법을 포함하는 치료 계획을 수립하였으며 상악 대구치를 원심 이동하기 위해 새로이 고안된 Frog appliance를 제작 및 적용하였다. 측모 두부방사선 사진으로 치료 결과를 평가하였으며 상악 제1대구치의 원심 이동이 4개월의 치료 기간 동안 이루어 졌고 1급의 구치 관계가 얻어졌다. 총 치료 기간은 16개월이 소요되었다. 두부방사선 사진을 평가한 결과 약간의 고정원 상실과 함께 대구치의 원심 이동이 치축 이동에 가깝게 일어난 것을 확인하였다. 결론적으로 Frog appliance는 환자의 협조를 요하지 않는 장치로서 간단하고 효과적으로 양측 대구치의 원심이동을 이룰 수 있는 구내 장치이다.
A STUDY ON TYPES OF APPROXIMATION IN THE SENSE OF 2-STRUCTURES
MEHMET AÇIKGÖZ,YUSUF KARAKUS,DOGAN DÖNMEZ 장전수학회 2011 Proceedings of the Jangjeon mathematical society Vol.14 No.1
The problem of approximation and best approximation has been studied by many mathematicians. Most of works have dealt with the existence,uniqueness and characterization of approximation and best approximations in spaces of continuous functions with values in Banach spaces. But little or no work on approximation has been done in the sense of 2-structures such 2-normed sapaces, generalized 2-normed spaces and 2-Banach spaces. The aim of this paper is to give the types of approximation and investigate the approx-imation in the sense of these spaces. In addition, we shall give some results and related examples on the sets of approximation and coapproximation.
Comparison of Outcomes of Standard and Oncoplastic Breast-Conserving Surgery
Mehmet ali Gulcelik,Lutfi Dogan,Murat Yuksel,Mithat Camlibel,Cihangir Ozaslan,Erhan Reis 한국유방암학회 2013 Journal of breast cancer Vol.16 No.2
Purpose: The aim of this study is to determine and to compare the oncological outcomes of bilateral reduction mammoplasty to standard breast-conserving surgery for breast cancer. Methods: One hundred sixty-two patients who received a quadrantectomy because of breast cancer (group 1) and 106 breast cancer patients with macromastia who underwent breast-conserving surgery via bilateral reduction mammoplasty (group 2) between 2003 and 2010 were enrolled in this study. Results: The mean follow-up time was 37 months for group 1 and 33 months for group 2. Surgical margins were wider than 2 mm in 82.7% and 10 mm in 76.5% of the patients in group 1. Eleven percent of patients had positive surgical margins in this group. When compared to group 2, the rates were 89%, 84%, and 8.4%, respectively. Three patients (1.8%) in group 1 and one patient (0.9%) in group 2 had local recurrence of the disease and received a mastectomy. No statistical significances were noted for either local recurrence or overall survival between the two groups. Conclusion: Bilateral reduction mammoplasty has some advantages as compared to the standard conventional breast-conserving surgery techniques without having any unfavorable effects on surgical margin confidence, local recurrence, and survival rates.
The Evaluatıon of Contralateral Breast Lesıons in Breast Cancer Patıents Usıng Reductıon Mammoplasty
Lutfi Dogan,Mehmet ali Gulcelik,Melda Bulut,Niyazi Karaman,Gamze Kiziltan,Cihangir Ozaslan 한국유방암학회 2011 Journal of breast cancer Vol.14 No.3
Purpose: This study evaluated the importance of routine pathological examination of contralateral breast specimens in breast cancer patients using reduction mammoplasty. Methods: The weight of breast tissue resected from the contralateral breast in 71 patients and the number of slices used for pathological evaluation were recorded. Breast lesions found in the contralateral breast and accompanying lesions with tumors were examined. Results: High risk proliferative lesions were reported in the contralateral breast of eight (11.2%) patients, and low-risk lesions were detected in 18 (25%). While the mean age of the patients with high-risk lesions was 45.6, it was 52.8 for the other patients (p=0.036). Conclusion: Bilateral reduction mammoplasty may be beneficial to delineate some pathologies in contralateral breasts even in those patients with normal clinical and radiological findings. The incidental discovery of these pathologies is much more likely in young breast cancer patients.