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Nanotechnology in the arena of cancer immunotherapy
Md. Asadujjaman,Kwan Hyung Cho,Dong-Jin Jang,김주은,Jun-Pil Jee 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.1
Cancer immunotherapy orchestrates the immunesystem of the human body to fi ght against cancer cells. Bydoing this, it has revolutionized cancer treatment. Toxicitiesarising from dose-limit and low rates of patient responsecontinue to be the major bottlenecks in clinical outcomes. The immune system has a close relationship with tumor. This leads to the combination of nanotechnology and immunotherapy. Nanotechnology can potentiate the effi cacy ofimmunotherapy by enhancing the delivery and retention,and narrowing the toxicity of immunomodulation. In thisregard, immunotherapy can combine with nanomedicine togive strategies that could lessen the side eff ects and improveclinical outcomes in patient populations. In this review, weexplore and recapitulate recent advances in nanoparticlebasedcancer immunotherapy.
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Jun‑Pil Jee,Won Young Lee,Md. Asadujjaman 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.4
Background Long-acting injectable formulations (LAIFs) have received substantial attention recently due to their advantages over conventional formulations, including easy administration, continuous and controlled release of drug over months, and the ability to maintain drug concentrations within the therapeutic range. The constant advances in biotechnology produce complex active pharmaceuticals that might be difficult to administer by conventional means. In particular, peptides, proteins, and antibodies are hard to administer orally given their physicochemical instability in the gastrointestinal tract and short half lives in blood. Therefore, LAIFs are a good candidate delivery system for such drugs. LAIFs reduce the frequency of application and improve patient compliance. For instance, LAIF-based antipsychotics can be more effective in patients with bipolar disorder and schizoaffective disorder. Area covered This review provides an overview of the various drug delivery technologies using LAIFs. Poly (lactic-coglycolic acid) microspheres, hydrogels, organogels, and liquid crystals were chosen as representative LAIFs, and their preparation methods, advantages, limitations, challenges, and prospects are discussed. Expert opinion LAIFs are an attractive delivery system for bio-macromolecules that might participate in the new drug paradigm in the future. While each LAIF-based delivery technology has its own unique advantages, there are still some limitations that need to be overcome, and studies are being performed to understand and address these limitations.
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