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        Filtering through the role of NRF3 in kidney disease

        Cody J. Schmidlin,Matthew B. Dodson,Donna D. Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.3

        Kidney disease affects * 10% of the populationworldwide, resulting in millions of deaths each year. Mechanistically, oxidative stress is a major driver of variouskidney diseases, and promotes the progression fromacute to chronic injury, as well as renal cancer development. NRF2, the master regulator of redox balance, hasbeen shown to protect against kidney disease through itsnegation of reactive oxygen species (ROS). However,many kidney diseases exhibit high levels of ROS as a resultof decreased NRF2 protein levels and transcriptionalactivity. Many studies have tested the strategy of usingNRF2 inducing compounds to alleviate ROS to prevent orslow down the progression of kidney diseases. Oppositely,in specific subsets of renal cancer, NRF2 is constitutivelyactivated and contributes to tumor burden and overall poorprognosis; therefore, there has been a recent interest instudies investigating the benefits of NRF2 inhibition. Inthis review, we summarize recent literature investigatingthe role of NRF2 and oxidative stress in various kidneydiseases, and how pharmacological modification of NRF2signaling could play a protective role.

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