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A Mitochondrial-Targeted Two-Photon Probe for Zinc Ion
Masanta, Goutam,Lim, Chang Su,Kim, Hyung Joong,Han, Ji Hee,Kim, Hwan Myung,Cho, Bong Rae American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.15
<P>We report a two-photon probe (SZn-Mito) for mitochondrial zinc ions ([Zn<SUP>2+</SUP>]<SUB>m</SUB>). This probe shows a 7-fold enhancement of two-photon-excited fluorescence in response to Zn<SUP>2+</SUP> with a dissociation constant (<I>K</I><sub arrange='stack'>d</SUB><sup arrange='stack'>TP</SUP>) of 3.1 ± 0.1 nM and pH insensitivity in the biologically relevant range, allowing the detection of [Zn<SUP>2+</SUP>]<SUB>m</SUB> in a rat hippocampal slice at a depth of 100−200 μm without interference from other metal ions through the use of two-photon microscopy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-15/ja200444t/production/images/medium/ja-2011-00444t_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja200444t'>ACS Electronic Supporting Info</A></P>
Masanta, Goutam,Heo, Cheol Ho,Lim, Chang Su,Bae, Sung Keun,Cho, Bong Rae,Kim, Hwan Myung The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.29
<P>We report a two-photon fluorescent probe (SHP-Mito) which can ratiometrically detect mitochondrial H<SUB>2</SUB>O<SUB>2</SUB> in live cells and intact tissues at >100 μm depth through the use of two-photon microscopy.</P> <P>Graphic Abstract</P><P>We report a two-photon fluorescent probe (SHP-Mito) which can ratiometrically detect mitochondrial H<SUB>2</SUB>O<SUB>2</SUB> in living tissue. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc00034b'> </P>
Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe
Lim, Chang Su,Masanta, Goutam,Kim, Hyung Joong,Han, Ji Hee,Kim, Hwan Myung,Cho, Bong Rae American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.29
<P>We report a ratiometric two-photon probe (SSH-Mito) for mitochondrial thiols. This probe shows a marked blue-to-yellow emission color change in response to RSH, a significant two-photon cross section, good mitochondrial thiol selectivity, low cytotoxicity, and insensitivity to pH over the biologically relevant pH range, allowing the direct visualization of RSH levels in live cells as well as in living tissues at 90–190 μm depth without interference from other biologically relevant species through the use of two-photon microscopy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-29/ja205081s/production/images/medium/ja-2011-05081s_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja205081s'>ACS Electronic Supporting Info</A></P>
A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue
Baek, Na Young,Heo, Cheol Ho,Lim, Chang Su,Masanta, Goutam,Cho, Bong Rae,Kim, Hwan Myung The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.38
<P>We report a highly sensitive two-photon probe (SZn2-Mito) which shows a 70-fold two-photon excited fluorescence enhancement in response to Zn<SUP>2+</SUP> and can selectively detect mitochondrial Zn<SUP>2+</SUP> in a rat hippocampal slice at a depth of 100–200 μm by using two-photon microscopy.</P> <P>Graphic Abstract</P><P>We report a highly sensitive two-photon probe (SZn2-Mito) which can selectively detect mitochondrial Zn<SUP>2+</SUP> in living tissue by two-photon microscopy. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc31077e'> </P>