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- 저자 : Marlies Frank (검색결과 2 건)
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U. Pranav Nayak,Frank Mücklich,María Agustina Guitar 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.4
By employing destabilization heat treatments (HT), it is possible to create microstructures possessing different fractionsof carbides, martensite, and austenite, which lead to varying tribological responses in abrasion-resistant high-chromiumwhite cast irons. In the current work, the destabilization temperature was kept constant at 980 °C, whereas the time wasvaried from 0 to 90 min. As a result, the microstructure of the 26 wt% Cr white cast iron had a mixture of M23C6secondarycarbides (SC), martensite, and a decrease in the amount of retained austenite (RA) with increasing destabilization holdingtime. The microstructures as well as their tribological characteristics were evaluated by combining confocal laser scanningmicroscopy, SEM, XRD, and EBSD, together with dry-sliding linear reciprocating wear tests. Results show that the volumefraction of SC were statistically comparable in samples destabilized for 0 and 90 min, although the average size was almosttwo-fold in the latter. This had direct implications on the wear properties where a decrease of up to 50% in the wear rate ofdestabilized samples compared to the non-treated material was observed. Furthermore, the sample with the lowest increase inthe matrix hardness (~ 20% higher than non-treated), showed the highest wear resistance. This was attributed to a favourabledistribution of the RA (~ 10%) and SC volume fraction (~ 5%), in combination with the harder martensitic matrix. Finally,the results obtained from this study shed light on the ability to alter the HT parameters to tune the microstructure dependingupon the application prerequisite.
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Cerebellar Nocardiosis and Myopathy from Long-Term Corticosteroids for Idiopathic Thrombocytopenia
Marlies Frank,Herbert Woschnagg,Gunther Molzer,Josef Finsterer 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.1
Infection of the central nervous system with Nocardia sp. usually manifests as supratentorial abscesses. Supratentorial and cerebellar abscesses from infection with Nocardia sp. following immunosuppression with long-term corticosteroids for idiopathic thrombocytopenia (ITP) have not been reported. An 83 years-old, human immunodeficiency virus (HIV)-negative, polymorbid male with ITP for which he required corticosteroids since age 53 years developed tiredness, dyspnoea, hemoptysis, abdominal pain, and progressive gait disturbance. Imaging studies of the lung revealed an enhancing tumour in the right upper lobe with central and peripheral necrosis, multiple irregularly contoured hyperdensities over both lungs, and right-sided pleural effusions. Sputum culture grew Nocardia sp. Neurological diagnostic work-up revealed dysarthria, dysphagia, ptosis, hypoacusis, tremor,dysdiadochokinesia, proximal weakness of the lower limbs, diffuse wasting, and stocking-type sensory disturbances. The neurological deficits were attributed to an abscess in the upper cerebellar vermis, myopathy from corticosteroids, and polyneuropathy. Meropenem for 37 days and trimethoprime-sulfamethoxazole for 3 months resulted in a reduction of the pulmonary, but not the cerebral lesions. Therefore, sultamicillin was begun, but without success. Long-term therapy with corticosteroids for ITP may induce not only steroid myopathy but also immune-incompetence with the development of pulmonary and cerebral nocardiosis. Cerebral nocardiosis may not sufficiently respond to long-term antibiotic therapy why switching to alternative antibiotics or surgery may be necessary.
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