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- 저자 : Mark A. Gill (검색결과 1 건)
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비모수적 기대최대치(NPEM) 연산방법에 의한 미국인과 재미동포 충수돌기염 환자에게 겐타마이신의 모집단 약물동태학
범진필(Jin Pil Burm),최준식(Jun Shik Choi),Stanford Jhee,Mark A. Gill 대한약학회 1995 약학회지 Vol.39 No.2
Population pharmacokinetics for gentamicin were compared with 24 American patients (16 male and 8 female) and 16 Korean-American appendicitis patients(12 male and 4 female). Two to six blood specimens were collected from all patients at the following times: just before a regularly scheduled infusion and at 1/2 hour after the end of a 1/2 hour infusion. Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constants(K), the slope of the relationship between K versus creatinine clearance(KS), the apparent volume of distribution(V), the slope of the relationship between V versus weight(VS), gentamicin clearance(CL) and the slope of the relationship between CL versus creatinine clearance and the VS(CS). The output includes a 3-dimensional plot of the joint probability density function(PDF), two marginal PDF, means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were 0.424 +/- 0.139(0.00429 +/- 0.00164) and 0.411 +/- 0.135 hr-1 (0.00475 +/- 0.00180[hr.mL/min/1.73 m2]-1) for American and Korean-American populations, respectively. The mean V(VS) were not different at 15.6 +/- 4.77(0.233 +/- 0.0526) and 15.1 +/- 3.84L(O.239 +/- 0.0492L/kg) for American and Korean-American populations, respectively (P>0.2). The mean CL(CS) were 6.28 +/- 1.85(0.0634 +/- 0.0191) and 5.70 +/- 1.77L/hr(0.0701 +/- 0.0215L/kg[hr.mL/min/1.73m2]) for American and Korean-American populations, respectively. There are no differences in gentamicin pharmacokinetics between American and Korean-American appendicitis patients.
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