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- 저자 : Manuela Caniça (검색결과 1 건)
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Daniela Jones-Dias,Vera Manageiro,Eugénia Ferreira,Deolinda Louro,Antibiotic Resistance Surveillance Program in Portugal Participants,Manuela Caniça 한국미생물학회 2014 The journal of microbiology Vol.52 No.6
A group of 124 Enterobacteriaceae isolates resistant to thirdgeneration cephalosporins, and collected in distinct healthcare facilities of different Portuguese regions was analysed. The great majority of the isolates were also resistant to fourthgeneration cephalosporins (83.9%), monobactam (96%),amoxicillin plus clavulanic acid (85.5%), and piperacillinplus tazobactam (66.9%). Overall, 84.7% (105/124) were multidrugresistant. Molecular methods enabled us to identify86.3% (107/124) extended-spectrum β-lactamases (ESBL)producers, revealing a diversity of class A β-lactamases fromdifferent families, like TEM (TEM-1, TEM-10, TEM-24, andTEM-52), SHV (SHV-1, SHV-12, and SHV-28), CTX-M(CTX-M-1, CTX-M-9, CTX-M-14, CTX-M-15, and CTXM-32), and GES (GES-1). We have also detected class C enzymeslike plasmid-mediated AmpC β-lactamases (PMAβs,DHA-1, and CMY-2) and chromosomal AmpCs in Enterobacterand Citrobacter spp. The PMAβ genetic context mappingsuggests association with mobile elements, plasmid importationand the potential emergence of these β-lactamases. The most prevalent β-lactamase detected was CTX-M-15(66.1%) and in 41.1% of the isolates it was associated withTEM-, OXA-type β-lactamases and Aac(6)’-Ib-cr, whichmight indicate that the respective genotype has settled inour country. Indeed, CTX-M-15 was distributed amongstdistinct clinical settings of several health care facilities(93.5%) from various regions. We provide evidence of a concerningclinical situation that includes vast occurrence ofESBLs, the settling of CTX-M β-lactamases, and the reportof plasmidic and chromosomal AmpC in Portugal.
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