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RISS 인기검색어
- 검색키워드
- 저자 : Manan J. Shah (검색결과 3 건)
- 무료
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Serotonin-Norepinephrine Reuptake Inhibitors for Pain Control: Premise and Promise
Marks, David M,Shah, Manan J,Patkar, Ashwin A,Masand, Prakash S,Park, Geun-Young,Pae, Chi-Un Bentham Science Publishers Ltd. 2009 Current neuropharmacology Vol.7 No.4
<P>The precise mechanisms of pain perception and transmission in the central nervous system have not been fully elucidated. However, extensive data support a role for the monoamine neurotransmitters, serotonin and norepinephrine, in the modulation of pain. Experiments with animal models of pain indicate that noradrenergic interventions, and to a lesser extent serotonergic interventions, reduce pain-related behavior. This is supported by data from clinical trials in humans in which antidepressants have been shown to reduce pain and functional impairment in central and neuropathic pain conditions. These effects are particularly well-studied in trials with serotonin-norepinephrine reuptake inhibitors (SNRIs), which have provided a useful tool in the clinician’s arsenal, particularly considering the limitations of other classes of pain medications such as opioids, anti-inflammatories, and anticonvulsants (i.e., limited efficacy, safety and tolerability issues). Moreover, painful physical symptoms are frequently comorbid with major psychiatric disorders such as major depressive disorder and anxiety disorders. This paper reviewed and summarized the rationale and potential role of SNRIs for the control of pain including clinical and preclinical background. Currently evidence does not definitely support a role of the SNRIs, while limited data propose a putative promise of SNRIs in the treatment of pain related disorders including fibromyalgia and depressed patients with multiple somatic complaints. More researches are warranted to generalize currently available preliminary evidences.</P>
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David M. Marks,Manan J. Shah,배치운 대한우울조울병학회 2009 우울조울병 Vol.7 No.2
Remarkable progresses have been achieved regarding the understanding of the neurophysiologic and neuropharma- cological bases of pain. The principal role of substance P, endogenous opioids, glutamate, serotonin, and norepine- phrine has been proposed in pain perception. With the progression of molecular biology, a potential role of dopamine in pain perception has been also shown in a numerous preclinical and clinical researches. In addition, dopaminergic agents have been suggested to be involved in modulation of pain process. Currently available preliminary findings have demonstrated that dopamine may be actively linked in endogenous control of pain systems, although the clear action mechanisms of dopamine neurotransmission in relation with pain modulation systems have to be further explored.
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Current advancements of magnetic nanoparticles in adsorption and degradation of organic pollutants
Ul-Islam, M.,Ullah, M. W.,Khan, S.,Manan, S.,Khattak, W. A.,Ahmad, W.,Shah, N.,Park, J. K. Springer Science + Business Media 2017 Environmental Science and Pollution Research Vol.24 No.14
<P>Nanotechnology is a fast-emerging field and has received applications in almost every field of life. Exploration of new synthetic technologies for size and shape control of nanomaterials is getting immense consideration owing to their exceptional properties and applications. Magnetic nanoparticles (MNPs) are among the most important group of nanoparticles thanks to their diverse applications in medical, electronic, environmental, and industrial sectors. There have been numerous synthetic routes of MNPs including thermal decomposition, co-precipitation, microemulsion, microwave assisted, chemical vapor deposition, combustion synthesis, and laser pyrolysis synthesis. The synthesized MNPs have been successfully applied in medical fields for therapy, bioimaging, drug delivery, and so on. Among environmental aspects, there has been great intimidation of organic pollutants in air and water. Utilization of various wastes as adsorbents has removed 80 to 99.9% of pollutants from contaminated water. MNPs as adsorbents compared to coarse-grained counterparts have seven times higher capacity in removing water pollutants and degrading organic contaminants. This study is focused to introduce and compile various routes of MNP synthesis together with their significant role in water purifications and degradation of organic compounds. The review has compiled recent investigation, and we hope it will find the interest of researchers dealing with nanoparticles and environmental research.</P>
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