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      • Oral Cancer Awareness of the General Public in Gorakhpur City, India

        Agrawal, Mamta,Pandey, Sushma,Jain, Shikha,Maitin, Shipra Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

        Objectives: Global cancer statistical data show that India has one of the highest incidence rates of oral cancer worldwide. Early detection is extremely important as it results in lower morbidity and death rates. The present study was undertaken to assess awareness of oral cancer and knowledge of its early signs and risk factors in the general public of the semi-urban Gorakhpur area of Uttar Pradesh (India). It was also intended to educate the same population for early detection by increasing their ability to recognize signs and risk factors. Method: A questionnaire-based household survey was conducted over a period of one month in different parts of Gorakhpur district, a region where tobacco use is apparently very high. A total of 2,093 persons participated in the survey. The collected data were analyzed using SPSS software to assess and associate oral cancer awareness with the prevalence, and abstract risk factors, as well as other confounding variables. Results: The general awareness, knowledge of signs and risk factors of oral cancer were found to be proportionate to the literacy level with the highest rate of awareness being among high school and graduates and lowest among illiterates. It was also observed that on most of these dimensions the younger age groups (<30 years) were significantly more knowledgeable. Conclusion: Overall, the awareness of oral cancer in the high-risk population of Gorakhpur was not satisfactory, pointing to a need for further dissemination of information on this issue and its associated risks. This is especially important for the youngsters, as this may possibly help them keep away from the deleterious habit of tobacco indulgence in any form. If necessary risk factor cessation counselling should be provided.

      • Synthesis and spectroscopic characterization of zinc ferrite nanoparticles

        Arora, Shefali,Nandy, Subhajit,Latwal, Mamta,Pandey, Ganesh,Singh, Jitendra P.,Chae, Keun H. Techno-Press 2022 Advances in nano research Vol.13 No.5

        Synthesis approaches usually affect the physical and chemical properties of ferrites. This helps ferrite materials to design them for desired applications. Some of these methods are mechanical milling, ultrasonic method, micro-emulsion, co-precipitation, thermal decomposition, hydrothermal, microwave-assisted, sol-gel, etc. These methods are extensively reviewed by taking example of ZnFe<sub>2</sub>O<sub>4</sub>. These methods also affect the microstructure and local structure of ferrite which ultimately affect the physical and chemical properties of ferrites. Various spectroscopic techniques such as Raman spectroscopy, Fourier Transform Infrared spectroscopy, Ultra Violet-Visible spectroscopy, Mossbauer spectroscopy, extended x-ray absorption fine structure, and electron paramagnetic resonance are found helpful to reveal this information. Hence, the basic principle and the usefulness of these techniques to find out appropriate information in ZnFe<sub>2</sub>O<sub>4</sub> nanoparticles is elaborated in this review.

      • KCI등재

        Care, management, and use of ferrets in biomedical research

        Ravindran Kumar Pramod,Pravin Kumar Atul,Mamta Pandey,S. Anbazhagan,Suhas T. Mhaske,R. Barathidasan 한국실험동물학회 2024 Laboratory Animal Research Vol.40 No.1

        The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century. It is a suitable non-rodent model in biomedical research because of its hardy nature, social behavior, diet and other habits, small size, and thus the requirement of a relatively low amount of test compounds and early sexual maturity compared with dogs and non-human primates. Ferrets and humans have numerous similar anatomical, metabolic, and physiological characteristics, including the endocrine, respiratory, auditory, gastrointestinal, and immunological systems. It is one of the emerging animal models used in studies such as influenza and other infectious respiratory diseases, cystic fibrosis, lung cancer, cardiac research, gastrointestinal disorders, neuroscience, and toxicological studies. Ferrets are vulnerable to many human pathogenic organisms, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), because air transmission of this virus between them has been observed in the laboratory. Ferrets draw the attention of the medical community compared to rodents because they occupy a distinct niche in biomedical studies, although they possess a small representation in laboratory research.

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        Phytochemical composition, in vitro bioactivity evaluation and in silico molecular docking study of fruit essential oils of Zanthoxylum armatum DC collected from Himalayan region of Uttarakhand, India

        Kabdal Tanuja,Karakoti Himani,Upadhyay Pringal,Kumar Ravendra,Prakash Om,Dhami Anamika,Latwal Mamta,Pandey Ganesh,Srivastava R.M.,Kumar Satya,Rawat D.S. 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2

        The present research aimed to analyze the nematicidal and insecticidal activity of the essential oil obtained from the fruits of Zanthoxylum armatum collected from Gumma village of Dharchula and Chandak village of Pithor agarh. After extraction via hydro distillation, the essential oils were subjected to GC–MS for their compositional analysis. A total of 10 and 13 components were identified for the Dharchula and Pithoragarh collection respectively. Linalool (32.86 %) was the major component in collection from Dharchula whereas it was totally absent in that of collection from Pithoragarh which has trans-sabinene hydrate (11.7 %) as its major component. Essential oils were tested against Meloidogyne incognita for their nematicidal activity and inhibition of egg hatching in laboratory conditions. It was found that the activity of Z. armatum from Dharchula shows high mortality of Meloidogyne incognita and more inhibition to the egg hatching. When tested for insecticidal activity against Lipaphis erysimi, collection from Dharchula presented stronger activity compared to Pithoragarh collec tion as shown by their LC 50 values 0.006 and 0.165 µL/mL respectively after 36 hrs. The in silico PASS study and molecular docking study was conducted to screen the nematicidal and insecticidal potential of the major com ponents on acetylcholinesterase receptors. Results showed good binding affinities and attributed the strongest inhibitory effect to verbenone for the target protein.

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