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      • KCI등재

        Transdermal Therapeutic System of Isradipine: Effect of Hydrophilic and Hydrophobic Matrix on In Vitro and Ex vivo Characteristics

        Mamatha Tirunagari,Mukkanti Khagga,Ramesh Gannu,Venkateswara Rao Jangala 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.7

        Isradipine (ISDP) is an effective calcium channel blocker used in the treatment of hypertension. It undergoes extensive first pass metabolism and bioavailability through the oral route is only about 15 to 24%. Hence we attempted to develop a matrix type controlled transdermal drug delivery system for ISDP. Formulations A1, A2, A3 were composed of Eudragit RL100 and hydroxypropyl methyl cellulose (HPMC) in 1:3, 1:1, 3:1 ratios; A4, A5, A6 were composed of Eudragit RS100 and HPMC in 1:3, 1:1, 3:1 ratios. All six formulations carried 5 mg of ISDP/patch area, 5% v/w of D-limonene, 15 % v/w of propylene glycol in methanol:dichloromethane (1:1). The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy and differential scanning calorimetry. The results suggested no physicochemical incompatibility between the drug and the polymers. The prepared transdermal drug delivery system were evaluated for physicochemical characteristics, mainly in vitro release and ex vivo permeation. The ex vivo permeation studies were carried out across excised rat skin using Franz diffusion cell. All the formulations exhibited satisfactory physicochemical characteristics. Cumulative amount of the drug released in 36 h from the six formulations were 1695.32, 1527.89, 1455.54, 1485.65, 1282.81 and 916.88 μg/cm2 respectively. Corresponding values for the cumulative amounts of drug permeated across the rat skin for the above matrix films were 1456.29, 1284.70, 1182.99, 1212.72, 1046.05, and 782.60 μg/cm2 respectively. By fitting the data into zero order, first order and Higuchi models, it was concluded that drug release from matrix films followed Higuchi model and the mechanism of drug release was diffusion mediated. Based on the physical evaluation, in vitro drug release and ex vivo permeation characteristics, it was concluded that for potential therapeutic use, monolithic drug matrix films A1, may be suitable for the development of a transdermal drug delivery system of ISDP.

      • OAPR-HOML'1: Optimal automated program repair approach based on hybrid improved grasshopper optimization and opposition learning based artificial neural network

        MAMATHA, T.,RAMA SUBBA REDDY, B.,BINDU, C SHOBA International Journal of Computer ScienceNetwork S 2022 International journal of computer science and netw Vol.22 No.4

        Over the last decade, the scientific community has been actively developing technologies for automated software bug fixes called Automated Program Repair (APR). Several APR techniques have recently been proposed to effectively address multiple classroom programming errors. However, little attention has been paid to the advances in effective APR techniques for software bugs that are widely occurring during the software life cycle maintenance phase. To further enhance the concept of software testing and debugging, we recommend an optimized automated software repair approach based on hybrid technology (OAPR-HOML'1). The first contribution of the proposed OAPR-HOML'1 technique is to introduce an improved grasshopper optimization (IGO) algorithm for fault location identification in the given test projects. Then, we illustrate an opposition learning based artificial neural network (OL-ANN) technique to select AST node-level transformation schemas to create the sketches which provide automated program repair for those faulty projects. Finally, the OAPR-HOML'1 is evaluated using Defects4J benchmark and the performance is compared with the modern technologies number of bugs fixed, accuracy, precession, recall and F-measure.

      • Intrusion Detection System for Mobile Ad hoc Networks Based on the Behavior of Nodes

        S. Mamatha,A. Damodaram 보안공학연구지원센터 2014 International Journal of Grid and Distributed Comp Vol.7 No.6

        A Mobile Ad hoc Network (MANET) can be defined as a network of mobile nodes that communicate over the wireless radio communication channel. It is also defined as a network without any underlying infrastructure and offers unrestricted mobility. Due to their open nature and lack of infrastructure, security for MANETs has become an intricate problem. To transmit data over such a network, generally any routing protocol that enables dynamic, self-starting multi hop routing between mobile nodes is used. However these routing protocols are vulnerable to various kinds of attacks. The conventional security mechanisms of protecting a network are not sufficient for these networks. Hence a second level of defense to detect and respond to the security problem called an Intrusion Detection System (IDS) is required. An IDS based on anomaly based intrusion detection that works by checking the behavior of the nodes was proposed to overcome some of the attacks like blackhole, grayhole and flooding attacks. Generally the malicious nodes demonstrate a different behavioral pattern of all the other normal nodes. So the specified approach where a Data Transmission Quality (DTQ) function is used to determine the behavior of the nodes as malicious or legitimate is used. The DTQ function is defined in such a way that it will be close to a constant or keep changing smoothly for genuine nodes and will keep on diminishing for malicious nodes. The proposed method was implemented using AODV as the routing protocol for transmitting data. The evaluation results show that the performance of the AODV protocol under attacks has improved significantly by using the proposed approach.

      • A Review on Automation of Ancient Epigraphical Images

        Preethi.P,Mamatha.H.R 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.4

        Inscriptions are the main source of historical study available throughout the world in constricted language. Epigraphy is the study of such inscriptions and the one who reads and understands (epigraphists or epigraphers) are in extinct condition, due to lack of knowledge transfer and interest. New inscriptions are found during excavation and finding expert epigraphers these days is a real challenge. Due to this, Researchers from the digital enhancement domain are actively involved in the decipherment of inscriptions all over the world. Automation Techniques uses Optical character recognition to convert the inscriptions into intelligible language. Currently works are witnessed in the literature survey on the global languages like Greek, Italian, Japanese, Russian, Latin, Iranian and Indian languages like Kannada, Tamil, Devanagari, Brahmi, Hoysala, and Pali. This paper reviews the techniques followed in automation of epigraphical scripts.

      • KCI등재

        Multiple variations in the branches of the coeliac trunk

        Suhani Sumalatha,Mamatha Hosapatna,K.R. Bhat,Antony Sylvan D`souza,Lakshmi Kiruba,Sushma R. Kotian 대한해부학회 2015 Anatomy & Cell Biology Vol.48 No.2

        Here we present a unique case of variation in the branching pattern of the coeliac trunk. In the present case, the coeliac trunk was replaced by two separate arterial trunks. The first arterial trunk bifurcated into the left gastric and the left hepatic arteries. The second arterial trunk bifurcated into a splenic artery and a hepato-gastroduodenal trunk. The hepato-gastroduodenal trunk presented an unusual course and termination. The right hepatic artery arising from the hepato-gastroduodenal trunk also showed a variant course. Such rare variations are important for gastroenterological surgeons and interventional radiologists due to increase in number of transplantation surgeries and live donor liver transplantations.

      • KCI등재

        Predicting the Outcome of a T20 Cricket Game Based on the Players’ Abilities to Perform Under Pressure

        Jitendra Sai Kota,Mamatha Vayelapelli 대한전자공학회 2020 IEIE Transactions on Smart Processing & Computing Vol.9 No.3

        With the advent of the Twenty20 format in cricket, the game has become more competitive. The number of nail-biting finishes that go to the last over has also increased as a result. As the game goes to the last over, the match result is mostly dependent on the effectiveness of batsmen at the crease and the player who is bowling the last over. This gave rise to an interesting idea for predicting the game result before the start of the final over based on the capabilities of the batsmen and the bowler. We used data from the first eight Indian Premier League (IPL) seasons as the training data, and from the last two IPL seasons as the test data. We trained and tested our model using Random Forest, Support Vector Machine (SVM) and k-nearest neighbors algorithms, and obtained the best accuracy using the SVM (89.36%).

      • KCI등재후보

        Development of New Robust Bivoltine Silkworm Hybrid $SR2{\times}SR5$ for Rearing throughout the Year

        Rao, P. Sudhakara,Nayaka, A. R. Narasimha,Mamatha, M.,Sowmyashree, T. S.,Bashir, Ifat,Ilahi, Irfan Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.14 No.2

        A Silkworm breeding programme was designed to develop a robust but productive bivoltine silkworm hybrid of Bombyx mori L. suitable for rearing throughout the year in tropical climate by utilizing indigenous polyvoltine and productive bivoltine breeds. The breeding was carried out under high temperature ($36^{\circ}C{\pm}1^{\circ}C$) and low humidity ($50{\pm}5%$) conditions in the environmental chamber. By $F_{12}$, three oval and three dumbbell breeds were isolated with higher survival and productive merits. These breeds were utilized in the hybrid evaluation along with other popular breeds. Based on combining ability test results, the hybrid $SR_2{\times}SR_5$ was selected for large scale testing and evaluated in different seasons. The evaluation studies indicated that the hybrid has higher viability and productive merits and it is suitable to rear throughout the year. The hybrid $SR_2{\times}SR_5$ recorded a survival of 92.0%, cocoon shell weight of 0.417 g, cocoon shell percentage of 23.0 and a filament length of 1042 meters under hot and dry conditions of environmental chamber compared to the control thermo-tolerant hybrid $CSR18{\times}CSR19$.

      • SCIESCOPUS

        Compaction and strength behavior of lime-coir fiber treated Black Cotton soil

        Ramesh, H.N.,Manoj Krishna, K.V.,Mamatha, H.V. Techno-Press 2010 Geomechanics & engineering Vol.2 No.1

        This paper describes the compaction and strength behavior of black cotton soil (BC soil) reinforced with coir fibers. Coir used in this study is processed fiber from the husk of coconuts. BC soil reinforced with coir fiber shows only marginal increase in the strength of soil, inhibiting its use for ground improvement. In order to further increase the strength of the soil-coir fiber combination, optimum percentage of 4% of lime is added. The effect of aspect ratio, percentage fiber on the behavior of the composite soil specimen with curing is isolated and studied. It is found that strength properties of optimum combination of BC soil-lime specimens reinforced with coir fibers is appreciably better than untreated BC soil or BC soil alone with coir fiber. Lime treatment in BC soil improves strength but it imparts brittleness in soil specimen. BC soil treated with 4% lime and reinforced with coir fiber shows ductility behavior before and after failure. An optimum fiber content of 1% (by weight) with aspect ratio of 20 for fiber was recommended for strengthening BC soil.

      • KCI등재후보

        Screening of Promising Bivoltine Hybrids of Mulberry Silkworm for their Susceptibility to Bombyx mori Nuclear Polyhedrosis Virus and Bombyx mori Infectious Flacherie Virus

        Kumar L. Hemanth,Sen Ratna,Nataraju B.,Mamatha M. Korean Society of Sericultural Science 2006 International Journal of Industrial Entomology Vol.12 No.2

        Central Sericultural Research and Training Institute, Mysore have evolved several highly productive bivoltine hybrids which can produce international grade raw silk. Among them $CSR2{\times}CSR4,\;CSR2{\times}CSR5,\;CSR3{\times}CSR6,\;CSR17{\times}CSR16,\;CSR18{\times}CSR19$ and $CSR12{\times}CSR6$ are being popularized in the field. There is a minimum difference in their economic characters but they appear to differ in survival. Though they are productive under high input management conditions, they are very susceptible to different diseases under normal rearing practices. No systematic attempts have been made to test their susceptibility status / resistance. Thus the present study is a modest attempt to screen the above six productive bivoltine hybrids to two important pathogens viz., Bombyx mori Nuclear Polyhedrosis Virus (BmNPV) and Bombyx mori Infectious Flacherie Virus (BmIFV) along with existing hybrid, $KA{\times}NB4D2$ to assess their susceptibility / resistance. The results shows that the productive hybrid $CSR2{\times}CSR4$ is the most resistant to BmNPV and it is suggested by its highest $LC_{50}$ value followed by $CSR12{\times}CSR6,\;KA{\times}NB4D2,\;CSR3{\times}CSR6,\;CSR17{\times}CSR16,\;CSR18{\times}CSR19,\;CSR2{\times}CSR5$. Based on the $LC_{50}$ value and $LT_{50}$ values for BmIFV, the hybrid $KA{\times}NB4D2$ was found to be the most resistant (1st position) one followed by $CSR3{\times}CSR6$ (2nd position) $CSR2{\times}CSR$ (3rd position) and $CSR12{\times}CSR6$ (4th position) $CSR17{\times}CSR16$, $CSR18{\times}CSR19$ (5th position) and $CSR2{\times}CSR5$ being the least. The response of 7 bivoltine hybrids to both the pathogens BmNPV and BmIFV indicates that, the hybrids $CSR2{\times}CSR4$, $CSR12{\times}CSR6$ and $KA{\times}NB4D2$ were found to be the most resistant when compared to others. Further, $KA{\times}NB4D2$ being less productive hybrid with a shell ratio of 20.08%, the other two hybrids $CSR2{\times}CSR4$ (Cocoon shell ratio, 21.44%) and $CSR12{\times}CSR6$ (cocoon shell ratio, 23.45%) can be considered to be most productive with superior quality cocoon and resistant to both BmNPV and BmIFV pathogens. The overall study indicated that the hybrid $CSR2{\times}CSR5$ is the most susceptible hybrid to both the pathogens.

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