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        Fundamental study on cancer therapy by blocking newborn blood vessels by magnetic force control

        KIRIMURA, Makoto,AKIYAMA, Yoko,NISHIJIMA, Shigehiro The Korea Institute of Applied Superconductivity a 2018 한국초전도저온공학회논문지 Vol.20 No.2

        In this study, a cancer treatment by accumulating and aggregating ferromagnetic particles in newborn blood vessels was examined. It is necessary for this treatment to control dispersion-aggregation property of ferromagnetic particles. Ferromagnetic particles required in this method disperse at low magnetic field, aggregate at high magnetic field and maintain the aggregation even after removal of the magnetic field. In order to control the dispersion-aggregation property, the surface of magnetite particles was modified with higher fatty acids having different lengths. As a result, we succeeded to prepare propionic acid-modified magnetite particles that form irreversible aggregation by magnetic field. The model experiments simulating newborn blood vessels showed that these particles can block the flow by the magnetic field, and the blockage was maintained after removal of the magnetic field.

      • KCI등재

        Fundamental study on cancer therapy by blocking newborn blood vessels by magnetic force control

        Makoto KIRIMURA,Yoko AKIYAMA,Shigehiro NISHIJIMA 한국초전도.저온공학회 2018 한국초전도저온공학회논문지 Vol.20 No.2

        In this study, a cancer treatment by accumulating and aggregating ferromagnetic particles in newborn blood vessels was examined. It is necessary for this treatment to control dispersion-aggregation property of ferromagnetic particles. Ferromagnetic particles required in this method disperse at low magnetic field, aggregate at high magnetic field and maintain the aggregation even after removal of the magnetic field. In order to control the dispersion-aggregation property, the surface of magnetite particles was modified with higher fatty acids having different lengths. As a result, we succeeded to prepare propionic acid-modified magnetite particles that form irreversible aggregation by magnetic field. The model experiments simulating newborn blood vessels showed that these particles can block the flow by the magnetic field, and the blockage was maintained after removal of the magnetic field.

      • KCI등재

        Watch Your Partner’s Behaviors: Motivation Contagion in L2 Pair Work

        ( Tomohito Hiromori ),( Masahiro Yoshimura ),( Makoto Mitsugi ),( Ryo Kirimura ) 범태평양 응용언어학회 2021 범태평양응용언어학회지 Vol.25 No.1

        Amid the increasing popularity of task-based language teaching, task motivation is considered one of the keys to success, but motivational influence among learners has not been sufficiently addressed in the literature. The purpose of this study is to investigate the process of motivation contagion in language learning pair work. Specifically, it tests the hypothesis that motivation contagion in pairs occurs either by observing the motivational orientation of the partner (i.e., priming), or as a result of the perceived expectations of the learning task (i.e., expectancy formation). A total of 140 Japanese university students worked in pairs on a picture description task. The analysis of the post-task questionnaires indicated that motivation contagion occurred both by priming and expectancy formation, but the impact of the latter was more significant. It was also found that highly motivated learners were strongly affected by expectancies about the quality of task involvement and interpersonal relations, while less motivated learners were influenced more by their partners’ motivation levels. Through the learners’ retrospective accounts, we also found that mutually supportive attitudes and behaviors play an essential role in boosting motivation contagion. The findings provide pedagogical implications for designing dyadic activities that can help learners motivate each other.

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