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ECM and GLR Based Multiuser Detection with I-CSI
Maio Antonio De,Episcopo Roberto,Lops Marco The Korea Institute of Information and Commucation 2005 Journal of communications and networks Vol.7 No.1
This paper deals with the problem of multiuser detection over a direct-sequence code-division multiple access (DS-CDMA) channel with incomplete channel state informations (I-CSI). We devise and assess two novel recursive detectors based on the expectation conditional maximization (ECM) algorithm and the generalized likelihood ratio (GLR) principle, respectively. Both receivers entail an affordable computational complexity. Moreover, the performance assessment, conducted via Monte Carlo techniques, shows that they achieve satisfactory performance levels and outperform linear detectors.
CONVERGENCE PROPERTIES OF HYPERSPACES
Maio, Giuseppe Di,Kocinac, Lj. D. R.,Nogura, Tsugunori Korean Mathematical Society 2007 대한수학회지 Vol.44 No.4
In this paper we investigate relationships between closure-type and convergence-type properties of hyperspaces over a space X and covering properties of X.
Di Maio, Alessandro,Skuba, Andrew,Himes, B Timothy,Bhagat, Srishiti L,Hyun, Jung Keun,Tessler, Alan,Bishop, Derron,Son, Young-Jin The Society 2011 The Journal of neuroscience Vol.31 No.12
<P>Dorsal root (DR) axons regenerate in the PNS but turn around or stop at the dorsal root entry zone (DREZ), the entrance into the CNS. Earlier studies that relied on conventional tracing techniques or postmortem analyses attributed the regeneration failure to growth inhibitors and lack of intrinsic growth potential. Here, we report the first in vivo imaging study of DR regeneration. Fluorescently labeled, large-diameter DR axons in thy1-YFPH mice elongated through a DR crush site, but not a transection site, and grew along the root at >1.5 mm/d with little variability. Surprisingly, they rarely turned around at the DREZ upon encountering astrocytes, but penetrated deeper into the CNS territory, where they rapidly stalled and then remained completely immobile or stable, even after conditioning lesions that enhanced growth along the root. Stalled axon tips and adjacent shafts were intensely immunolabeled with synapse markers. Ultrastructural analysis targeted to the DREZ enriched with recently arrived axons additionally revealed abundant axonal profiles exhibiting presynaptic features such as synaptic vesicles aggregated at active zones, but not postsynaptic features. These data suggest that axons are neither repelled nor continuously inhibited at the DREZ by growth-inhibitory molecules but are rapidly stabilized as they invade the CNS territory of the DREZ, forming presynaptic terminal endings on non-neuronal cells. Our work introduces a new experimental paradigm to the investigation of DR regeneration and may help to induce significant regeneration after spinal root injuries.</P>
Convergence properties of hyperspaces
Giuseppe Di Maio,Ljubi\v{s}a D.R. Ko\v{c}inac,Tsugunori Nogura 대한수학회 2007 대한수학회지 Vol.44 No.4
In this paper we investigate relationships between closure-type and convergence-type properties of hyperspaces over a space X andcovering properties ofX .
Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
Isabel Rivera,David M. Cauvi,Nelson Arispe,Antonio De Maio 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.4
Backgrounds: Alpha calcium channel blockers (CCB) are widely prescribed for the treatment of hypertension, including Nitrendipine (NTD). The anti-hypertension effect of NTD is related to binding and blocking the activity of the voltage-gated L-type calcium channels. These channels consist of four subunits (α1, α2/δ, γ and β subunits), localized in the plasma membrane. Methods: Cellular proliferation was determined by the XTT method and apoptosis was measured by flow cytometry. The expression of the α1c subunit (Cacna1c) of the voltage-gated L-type calcium channels was reduced by siRNA and assessed by quantitative RT-PCR. Results: NTD blocked the proliferation of murine neuroblastoma (N2a cells) and induced apoptosis in a concentration- dependent manner. A decrease in Cacna1c expression did not have a significant effect on NTD toxicity of N2a cells. Conclusion: NTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.