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Triazenoindazoles and Triazenopyrazolopyridines: Design, Synthesis, and Cytotoxic Activity
Maha Abdel-Hakeem 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
Several triazenoindazoles 3a-e and triazinopyrazolopyridines 6a-i were prepared through the reaction of the corresponding 3-amino-4-chloroindazole and 3-aminopyrazolopyridine diazonium salts 2 and 5 with a number of secondary amines. All compounds were evaluated for their in vitro cytotoxic activity on three cell lines, HepG2, MCF7, and HeLa. Most compounds inhibited cell growth with IC50 less than 0.1 μM. Compound 6d was the most potent, with an IC50 of 0.03 μM against HepG2 and 0.05 μM against MCF7 and HeLa cells.