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RISS 인기검색어
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- 저자 : M. Loredana Marcovecchio (검색결과 1 건)
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Usefulness of nBos d 4, 5 and nBos d 8 Specific IgE Antibodies in Cow’s Milk Allergic Children
Anna Cingolani,Sabrina Di Pillo,Marzia Cerasa,Daniele Rapino,Nicola Pietro Consilvio,Marina Attanasi,Alessandra Scaparrotta,M. Loredana Marcovecchio,Angelika Mohn,Francesco Chiarelli 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.2
Purpose: The aim of study was to assess the value of recombinants in predicting the degree of symptoms in children with and without anaphylaxisto cow’s milk. Methods: The study included 79 children (70±40 months) referred to the Allergological Unit of the Pediatric Department betweenthe years 2008-2012. Group A was composed of 17 children (78±49.6 months) with anaphylaxis after ingestion of milk. Group B was composed of62 children (73.1±38.6 months) without a history of anaphylaxis, but with less severe symptoms (gastrointestinal and/or skin symptoms). All patientsfrom Group B had a positive open challenge with cow’s milk. All patients underwent an allergic evaluation and blood samples were collectedto test for IgE to recombinans of milk (nBos d 4, 5, 8). Results: A significant difference in nBos d 8 emerged with higher levels in Group A (median[IQR]=2.80 [0.91-16.1]) than B (0.65 [0.24-1.67]; P=0.006), whereas there were no statistically significant differences for nBos d 4 and 5. The recombinants’sum was higher in Group A than B: 8.39 [2.72-41.39] vs 3.04 [1.85-7.31] kUA/L; P=0.044. The recombinant nBos d 8 was superior to the otherrecombinants in identifying children at risk for anaphylaxis, with an area under the curve of 0.718 (95% CI, 0.57-0.86, P=0.006). Considering acutoff of 1.8 kUA/L, nBos d 8 had the most favorable sensitivity and specificity ratio (sensitivity=0.65, specificity=0.77) with an odd ratio of 6.02(95% C.I: 1.89-19.23). Conclusions: This study suggested 2 phenotypes of allergic children, “high-anaphylaxis-risk” and “milder-risk”. These typescan be differentiated through measuring the level of IgE to nBos d 8. Key Words: Child; symptoms; milk; allergy; recombinant proteins
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