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M Kavitha,Kalaimagal, S Mercy,N Sangeetha,D Ganesh 강원대학교 산림과학연구소 2009 Journal of Forest Science Vol.25 No.2
Multiple shoot induction and plant regeneration using apical bud and nodal explants of 100 year old tree of Anthocephalus cadamba, an important sacred and medicinal tree in India was achieved for the first time. Aseptic explants cultured in Murashige and Skoog (MS) medium augmented with different concentrations of BAP (0.1, 0.5, 1.0, 2.5, 5.0 and 10 mg/l), when maintained for 60 days, healthy shoots were induced in presence of BAP (1 mg/l). Lower concentrations of BAP (0.1 - 0.5 mg/l) induced only one shoot per explant. Increase in number of shoots per explant was observed in presence of higher concentrations of BAP (2.5, 5.0 and 10 mg/l). However, elongation of shoots was completely inhibited. Bud break and shoot regeneration was largely associated with seasonal factors. Apical buds cultured during June to August exhibited early bud break within two weeks of initial culture. In rest of the months, bud break and shoot regeneration was very slow irrespective of the various concentrations of BAP used in the medium. Explants sourced from three different maturity levels of shoots indicated that actively growing shoots from the mother plant with 1 – 2 nodal segments was more suitable for culture initiation than the explants collected from mature shoots at dormant stage. Regenerated shoots with 2 – 3 pairs of leaves when transferred to half strength MS medium fortified with IBA (1 mg/l), 60% of the shoots induced healthy roots, indicating the possibility of large scale micropropagation.
Kavitha, M.,Kalaimagal, I.,Mercy, S.,Sangeetha, N.,Ganesh, D. Institute of Forest Science 2009 Journal of Forest Science Vol.25 No.2
Multiple shoot induction and plant regeneration using apical bud and nodal explants of 100 year old tree of Anthocephalus cadamba, an important sacred and medicinal tree in India was achieved for the first time. Aseptic explants cultured in Murashige and Skoog (MS) medium augmented with different concentrations of BAP (0.1, 0.5, 1.0, 2.5, 5.0 and 10 mg/l), when maintained for 60 days, healthy shoots were induced in presence of BAP (1 mg/l). Lower concentrations of BAP (0.1 - 0.5 mg/l) induced only one shoot per explant. Increase in number of shoots per explant was observed in presence of higher concentrations of BAP (2.5, 5.0 and 10 mg/l). However, elongation of shoots was completely inhibited. Bud break and shoot regeneration was largely associated with seasonal factors. Apical buds cultured during June to August exhibited early bud break within two weeks of initial culture. In rest of the months, bud break and shoot regeneration was very slow irrespective of the various concentrations of BAP used in the medium. Explants sourced from three different maturity levels of shoots indicated that actively growing shoots from the mother plant with 1 - 2 nodal segments was more suitable for culture initiation than the explants collected from mature shoots at dormant stage. Regenerated shoots with 2 - 3 pairs of leaves when transferred to half strength MS medium fortified with IBA (1 mg/l), 60% of the shoots induced healthy roots, indicating the possibility of large scale micropropagation.
Correlation between EGFR Gene Mutations and Lung Cancer: a Hospital-Based Study
Kavitha, Matam,Iravathy, Goud,Adi Maha, Lakshmi M,Ravi, V,Sridhar, K,Vijayanand, Reddy P,Chakravarthy, Srinivas,Prasad, SVSS,Tabassum, Shaik Nazia,Shaik, Noor Ahmad,Syed, Rabbani,Alharbi, Khalid Khala Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 men and 30 women. Mutations were detected in exon 19 (delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751) in 32 patients, exon 20 (S786I, T790M) in 16, and exon 21 (L858R) in 15. No mutations were observed in exon 18. The 63 patients with EFGR mutations were considered for upfront therapy with oral tyrosine kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control patients had no mutations in any of the exons studied. The advent of EGFR TKI therapy has provided a powerful new treatment modality for patients diagnosed with NSCLC. The study emphasizes the frequency of EGFR mutations in NSCLC patients and its role as an important predictive marker for response to oral TKI in the south Indian population.
Seismic behavior of steel and sisal fiber reinforced beam-column joint under cyclic loading
S.M. Kavitha,G. Venkatesan,Siva Avudaiappan,Chunwei Zhang 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.88 No.5
The past earthquakes revealed the importance of the design of moment-resisting reinforced concrete framed structures with ductile behavior. Due to seismic activity, failures in framed structures are widespread in beam-column joints. Hence, the joints must be designed to possess sufficient strength and stiffness. This paper investigates the effects of fibers on the ductility of hybrid fiber reinforced self-compacting concrete (HFRSCC) when subjected to seismic actions; overcoming bottlenecks at the beam-column joints has been studied by adding low modulus sisal fiber and high modulus steel fiber. For this, the optimized dose of hooked end steel fiber content (1.5%) was kept constant, and the sisal fiber content was varied at the rate of 0.1%, up to 0.3%. The seismic performance parameters, such as load-displacement behavior, ductility, energy absorption capacity, stiffness degradation, and energy dissipation capacity, were studied. The ductility factor and the cumulative energy dissipation capacity of the hybrid fiber (steel fiber, 1.5% and sisal fiber, 0.2%) added beam-column joint specimen is 100% and 121% greater than the control specimen, respectively. And also the stiffness of the hybrid fiber reinforced specimen is 100% higher than the control specimen. Thus, the test results showed that adding hybrid fibers instead of mono fibers could significantly enhance the seismic performance parameters. Therefore, the hybrid fiber reinforced concrete with 1.5% steel and 0.2% sisal fiber can be effectively used to design structures in seismic-prone areas.
Deposition of zinc–zinc phosphate composite coatings on steel by cathodic electrochemical treatment
Kavitha, C.,Sankara Narayanan, T. S.,Ravichandran, K.,Park, I. S.,Lee, M. H. Springer Science + Business Media 2014 Journal of coatings technology and research Vol.11 No.3
The present work aims at the development of an energy-efficient and eco-friendly approach for the deposition of zinc phosphate coatings on steel. The study describes the possibility of preparing zinc-zinc phosphate composite coatings by cathodic electrochemical treatment using dilute phosphoric acid as an electrolyte and zinc as an anode. The methodology enables the preparation of coatings with different proportions of zinc and zinc phosphate by suitably varying the applied current density, pH, and treatment time. Adhesion of the coating on mild steel and adhesion of paint film on the phosphate coating were found to be good. The surface morphology of the coatings exhibited platelet-type features and small white crystals (agglomerated at some places) which represented zinc and zinc phosphate, respectively. An increase in current density (from 20 to 50 mA/cm(2)) increased the size of the zinc crystals, and coatings prepared at 40 and 50 mA/cm(2) resembled that of electrodeposited zinc. Since the proportions of zinc and zinc phosphate could be varied with applied current density, pH, and treatment time, it would be possible to use this methodology to prepare coatings that would offer different degrees of corrosion protection.
CONTROLLABILITY OF IMPULSIVE FRACTIONAL EVOLUTION INTEGRODIFFERENTIAL EQUATIONS IN BANACH SPACES
M. MALLIKA ARJUNAN,V. KAVITHA 한국산업응용수학회 2011 Journal of the Korean Society for Industrial and A Vol.15 No.3
According to fractional calculus theory and Banach’s fixed point theorem, we establish the sufficient conditions for the controllability of impulsive fractional evolution integrodifferential equations in Banach spaces. An example is provided to illustrate the theory.
M. Azhagar Raj,A. Kavitha 한국자기학회 2020 Journal of Magnetics Vol.25 No.4
This paper investigates the complete performance impact analysis of Synchronous Reluctance Motor (SynRM) designed for an electric Auto Rickshaw application. Here, different magnetic core steel grades are used for the same motor geometry with the TLA rotor. As it is an electric traction application, proper operation of the motor under various operating specifications is critical. Therefore, a thorough study is conducted using the finite-element method combined with an experiment-based magnetic material model at rated speed. Based on the magnetization and hysteresis characteristics of the steel sheets, variations on the performance indexes such as the average torques, torque ripples, and iron losses by using a different stator and rotor materials are investigated. Some valuable comparison results are provided through simulation and experimental validation results are shown with a prototype built.
B. Kavitha,M. Dhanam 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.1
Films of Cu(InAl)Se2 were deposited onto glass substrates by SILAR (successive ionic layer adsorption and reaction) method. All the deposited films were found to be polycrystalline in nature exhibiting the chalcopyrite structure with the crystallite orientation along (112), (220/204) and (116/312) directions. The photocurrent was found to increase with increase in film thickness and also with increase of light intensity. Photocurrent spectra showed a peak related to the band-to-band transition. The spectral response of Cu(InAl)Se2 thin films was studied by allowing the radiation to pass through a series of interference filters in the wavelength range 300 to 1200 nm. Films of higher thickness exhibited higher photosensitivity while lower thickness films exhibited moderate photosensitivity. Cu(InAl)Se2-based solar cells with different types of buffer layers such as CdS, CdS:Cu, CdS:In were fabricated. The current and voltage were measured using an optical power meter and an electrometer and the fabricated solar cells were illuminated using 100 mW/cm2 white light under AM1 conditions.