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Gisela MÜLLER-PLATH,David JUNG,Martin MÜLLER 국제이네비해양경제학회 2018 International Journal of e-Navigation and Maritime Vol.10 No.1
Electronic Charting systems (ECS) in yachting and boating are the non-professional counterparts to ECDIS in commercial shipping. In the absence of legal regulations on design and use, a wide variety of products have de-veloped. Their usability is not only safety critical but often even determines whether navigation functions like route building or track recording are used at all. With two empirical studies employing standard usability meth-ods from human factors research, we assessed the usability of a variety of current ECSs on a sailing yacht. In study 1, nine usability experts conducted multimethod analyses while sailing in typical cruising areas on sea. Building on the results, a standardized user test was designed and carried out with 12 prototypical users plus 3 usability experts in inland waters (study 2). Finally, a set of 38 design and usability guidelines were formulated. The guidelines may not only help boat owners and charter companies in selecting a current market product but also aid manufacturers in designing their future products. Contributions: David Jung (study 1) and Martin Müller (study 2) conducted the studies and formulated the guide-lines. Gisela Müller-Plath designed and managed the research project ANeMoS (Analysing Use and Impact of NewMedia on Sailboats) which the present work is part of, commanded the sailing yacht, and wrote the paper.
Mü,ller, Martin C.,Cortes, Jorge E.,Kim, Dong-Wook,Druker, Brian J.,Erben, Philipp,Pasquini, Ricardo,Branford, Susan,Hughes, Timothy P.,Radich, Jerald P.,Ploughman, Lynn,Mukhopadhyay, Jaydip,Hochh American Society of Hematology 2009 Blood Vol.114 No.24
<B>Abstract</B><P>Dasatinib is a BCR-ABL inhibitor with 325-fold higher potency than imatinib against unmutated BCR-ABL in vitro. Imatinib failure is commonly caused by BCR-ABL mutations. Here, dasatinib efficacy was analyzed in patients recruited to phase 2/3 trials with chronic-phase chronic myeloid leukemia with or without BCR-ABL mutations after prior imatinib. Among 1043 patients, 39% had a preexisting BCR-ABL mutation, including 48% of 805 patients with imatinib resistance or suboptimal response. Sixty-threedifferent BCR-ABL mutations affecting 49 amino acids were detected at baseline, with G250, M351, M244, and F359 most frequently affected. After 2 years of follow-up, dasatinib treatment of imatinib-resistant patients with or without a mutation resulted in notable response rates (complete cytogenetic response: 43% vs 47%) and durable progression-free survival (70% vs 80%). High response rates were achieved with different mutations except T315I, including highly imatinib-resistant mutations in the P-loop region. Impaired responses were observed with some mutations with a dasatinib median inhibitory concentration (IC50) greater than 3nM; among patients with mutations with lower or unknown IC50, efficacy was comparable with those with no mutation. Overall, dasatinib has durable efficacy in patients with or without BCR-ABL mutations. All trials were registered at http://www.clinicaltrials.gov as NCT00123474, NCT00101660, and NCT00103844.</P>
A mathematical model for the two-learners problem
Mü,ller, Jan Saputra,Vidaurre, Carmen,Schreuder, Martijn,Meinecke, Frank C,von Bü,nau, Paul,Mü,ller, Klaus-Robert IOP 2017 Journal of neural engineering Vol.14 No.3
<P> <I>Objective</I>. We present the first generic theoretical formulation of the co-adaptive learning problem and give a simple example of two interacting linear learning systems, a human and a machine. <I>Approach</I>. After the description of the training protocol of the two learning systems, we define a simple linear model where the two learning agents are coupled by a joint loss function. The simplicity of the model allows us to find learning rules for both human and machine that permit computing theoretical simulations. <I>Main results</I>. As seen in simulations, an astonishingly rich structure is found for this eco-system of learners. While the co-adaptive learners are shown to easily stall or get out of sync for some parameter settings, we can find a broad sweet spot of parameters where the learning system can converge quickly. It is defined by mid-range learning rates on the side of the learning machine, quite independent of the human in the loop. Despite its simplistic assumptions the theoretical study could be confirmed by a real-world experimental study where human and machine co-adapt to perform cursor control under distortion. Also in this practical setting the mid-range learning rates yield the best performance and behavioral ratings. <I>Significance</I>. The results presented in this mathematical study allow the computation of simple theoretical simulations and performance of real experimental paradigms. Additionally, they are nicely in line with previous results in the BCI literature.</P>
Mü,ller, Detlef,Kolgotin, Alexei,Mattis, Ina,Petzold, Andreas,Stohl, Andreas The Optical Society 2011 Applied optics Vol.50 No.14
<P>Inversion with two-dimensional (2-D) regularization is a new methodology that can be used for the retrieval of profiles of microphysical properties, e.g., effective radius and complex refractive index of atmospheric particles from complete (or sections) of profiles of optical particle properties. The optical profiles are acquired with multiwavelength Raman lidar. Previous simulations with synthetic data have shown advantages in terms of retrieval accuracy compared to our so-called classical one-dimensional (1-D) regularization, which is a method mostly used in the European Aerosol Research Lidar Network (EARLINET). The 1-D regularization suffers from flaws such as retrieval accuracy, speed, and ability for error analysis. In this contribution, we test for the first time the performance of the new 2-D regularization algorithm on the basis of experimental data. We measured with lidar an aged biomass-burning plume over West/Central Europe. For comparison, we use particle in situ data taken in the smoke plume during research aircraft flights upwind of the lidar. We find good agreement for effective radius and volume, surface-area, and number concentrations. The retrieved complex refractive index on average is lower than what we find from the in situ observations. Accordingly, the single-scattering albedo that we obtain from the inversion is higher than what we obtain from the aircraft data. In view of the difficult measurement situation, i.e., the large spatial and temporal distances between aircraft and lidar measurements, this test of our new inversion methodology is satisfactory.</P>
Topological contact dynamics I: symplectization and applications of the energy-capacity inequality
Mü,ller, Stefan,Spaeth, Peter Walter de Gruyter GmbH 2015 Advances in geometry Vol.15 No.3
<B>Abstract</B><P>We introduce topological contact dynamics of a smooth manifold carrying a cooriented contact structure, generalizing previous work in the case of a symplectic structure [27] or a contact form [5]. A topological contact isotopy is not generated by a vector field; nevertheless, the group identities, the transformation law, and classical uniqueness results in the smooth case extend to topological contact isotopies and homeomorphisms, giving rise to an extension of smooth contact dynamics to topological dynamics. Our approach is via symplectization of a contact manifold, and our main tools are an energy-capacity inequality we prove for contact diffeomorphisms, combined with techniques from measure theory on oriented manifolds. We establish non-degeneracy of a Hofer-like bi-invariant pseudo-metric on the group of strictly contact diffeomorphisms constructed in [4]. The topological automorphism group of the contact structure exhibits rigidity properties analogous to those of symplectic diffeomorphisms, including C</P>
Differential Rapid Screening of Phytochemicals by Leaf Spray Mass Spectrometry
Thomas Müller,R. Graham Cooks 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.3
Ambient ionization can be achieved by generating an electrospray directly from plant tissue (“leaf spray”). The resulting mass spectra are characteristic of ionizable phytochemicals in the plant material. By subtracting the leaf spray spectra recorded from the petals of two hibiscus species H. moscheutos and H. syriacus one gains rapid access to the metabolites that differ most in the two petals. One such compound was identified as the sambubioside of quercitin (or delphinidin) while others are known flavones. Major interest centered on a C19H29NO5 compound that occurs only in the large H. moscheutos bloom. Attempts were made to characterize this compound by mass spectrometry alone as a test of such an approach. This showed that the compound is an alkaloid, assigned to the polyhydroxylated pyrrolidine class, and bound via a C3 hydrocarbon unit to a monoterpene.