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- 저자 : Luyong (검색결과 4 건)
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Lu, Yong Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.32 No.2
The response of concrete structures subjected to shock and blast load involves a rapid transient phase, during which material breach may take place. Such an effect could play a crucial role in determining the residual state of the structure and the possible dispersion of the fragments. Modelling of the transient phase response poses various challenges due to the complexities arising from the dynamic behaviour of the materials and the numerical difficulties associated with the evolving material discontinuity and large deformations. Typical modelling approaches include the traditional finite element method in conjunction with an element removal scheme, various meshfree methods such as the SPH, and the mesoscale model. This paper is intended to provide an overview of several alternative approaches and discuss their respective applicability. Representative concrete material models for high pressure and high rate applications are also commented. Several recent application studies are introduced to illustrate the pros and cons of different modelling options.
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Lu, Yong,Tu, Zhenguo Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.2
As a brittle and heterogeneous material, concrete behaves differently under different stress conditions and its bulk strength is loading rate dependent. To a large extent, the varying behavioural properties of concrete can be explained by the mechanical failure processes at a mesoscopic level. The development of a computational mesoscale model in a general finite element environment, as presented in the preceding companion paper (Part 1), makes it possible to investigate into the underlying mechanisms governing the bulk-scale behaviour of concrete under a variety of loading conditions and to characterise the variation in quantitative terms. In this paper, we first present a series of parametric studies on the behaviour of concrete material under quasi-static compression and tension conditions. The loading-face friction effect, the possible influences of the non-homogeneity within the mortar and ITZ phases, and the effect of randomness of coarse aggregates are examined. The mesoscale model is then applied to analyze the dynamic behaviour of concrete under high rate loading conditions. The potential contribution of the mesoscopic heterogeneity towards the generally recognized rate enhancement of the material compressive strength is discussed.
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A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity
Zhang, Yang,Xie, Jie,Zhang, Luyong,Li, Cong,Chen, Hongxia,Gu, Ying,Zhao, Jingquan Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.12
Elsinochrome A (EA) possesses the highest singlet-oxygen quantum yield (0.98) amongst the perilenoquinoid pigments and may be suitable as a phototherapeutic drug. However, there have been virtually no studies into its medicinal applications. Based on the analysis of chemical derivatives of hypocrellins (the same family as EA), 5-(3-mercapto-1-propanesulfonic acid)-substituted elsinochrome A (MPEA) with an amphiphilicity was designed and synthesized by considering drug delivery and biological activity requirements. MPEA possesses a water solubility of 5.1 mg $mL^{-1}$, which is just sufficient to enable dissolution at a clinically acceptable concentration, while its partition coefficient (n-octanol/phosphate buffered saline) of 7 guarantees affinity to biological targets. MPEA could photogenerate semiquinone anion radicals and reactive oxygen species, especially singlet oxygen, at a yield of 0.73, which approaches that for hypocrellin B. Biological tests confirmed that the photodynamic activity of MPEA was as high as 60% of that of its parent EA, which is significantly higher than that of most other photosensitizers.
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Yanyan Li,Jing Shang,Zhenzhou Jiang,Luyong Zhang,Xiurong Su 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.1
Peptides derived from the sea cucumber Apostichopus japonicas have immunomodulatory and antioxidant activities. Three dosage levels of peptide hydrolysates were fed to Institute of Cancer Research (ICR) mice. Standardized Y and Morris water mazes were used to determine the effects of A. japonicas peptides on learning and memory. All 3 mouse test groups showed reductions in the latency period (LP), the number of times that a mouse swam over the location of a platform (NCP), the ratio of the distance from a target quadrant to the total swimming distance (DTQ), and the time spent in the target quadrant (TTQ). Microarray analysis was then carried out and 308 genes were differentially expressed between groups, of which 235 were up and 73 were down regulated in the brains of test group animals, compared with control group animals. Expressions of genes identified in microarrays were then analyzed using qRT-PCR.
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