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Hybrid ceramics-based cancer theranostics
Guan Qingwen,He Binbin,Huang Jie,Lu Helen H.,Wang Min 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.4
Cancer is a major threat to human lives. Early detection and precisely targeted therapy/therapies for cancer is the most eff ective way to reduce the diffi culties (e.g., side eff ects, low survival rate, etc.) in treating cancer. To enable eff ective can- cer detection and treatment, ceramic biomaterials have been intensively and extensively investigated owing to their good biocompatibility, high bioactivity, suitable biodegradability and other distinctive properties that are required for medical devices in oncology. Through hybridization with other materials and loading of imaging agents and therapeutic agents, nanobioceramics can form multifunctional nanodevices to simultaneously provide diagnostic and therapeutic functions for cancer patients, and these nanodevices are known as hybrid ceramics-based cancer theranostics. In this review, the recent developments of hybrid ceramics-based cancer theranostics, which include the key aspects such as their preparation, bio- logical evaluation and applications, are summarized and discussed. The challenges and future perspectives for the clinical translation of hybrid ceramics-based cancer theranostics are also discussed. It is believed that the potential of hybrid ceramic nanoparticles as cancer theranostics is high and that the future of these theranostics is bright despite the diffi culties along the way for their clinical translation.