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- 저자 : Longxuan Li (검색결과 2 건)
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Hongbo Liu,Longxuan Wang,Yixin Yang,Ting Zhou,Jing Li 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.5
Austenitic S30408 stainless steel exhibits good low-temperature resistance and good welding performance. This steel is often used in liquefied natural gas stainless steel storage tanks. During the construction process, the tank wall is primarily connected by butt weld joints. Because welded joints are easily affected by temperature, low-temperature weld cracking can reduce the safety of structures. To study the cryogenic mechanical properties of austenitic S30408 stainless steel welded joints at low temperatures, the low-temperature mechanical properties of austenitic S30408 stainless steel base metal and welded joint components were studied by tensile tests from − 60 to 20 °C and scanning electron microscopy analysis of fractures at various temperatures. The results show that when the temperature decreases, the stress–strain curve of base metal components changes from a power function type to an inverted "s" type; in addition, secondary hardening occurs. The yield strength and tensile strength of the welded joint and base metal increased with decreasing temperature, and the elongation and reduction of area decreased. The plastic deformation capacity of the welded joint was significantly lower than that of the base metal, and there were obvious inclusions in the microstructure.
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Defang Pang,Lu Wang,Jing Dong,Xiaoyin Lai,Qijuan Huang,Richard Milner,Longxuan Li 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
We have previously demonstrated that in response to cerebral ischemia (CI), the growth factor angiopoietin-1 (Ang1) and α5β1 integrin are both induced in cerebral vessels, which likely provide positive signals driving the endogenous angiogenic response and vascular protection after CI. However, the precise relationship between endothelial Ang1 and α5β1 integrin after CI remains poorly understood. Here, we investigated the effects of the interaction between the Ang1/Tie2 system and α5β1 integrin on brain endothelial cells (BECs) under cerebral ischemic conditions in vivo and in vitro. Immunofluorescence analysis demonstrated that integrin α5β1 co-localized with Tie2/phosphorylated Tie2 on cerebral vessels in the penumbra. The in vitro study showed that oxygen–glucose deprivation/restoration (OGD/R) induced the expression of the Ang1 receptor Tie2 on BECs in a manner similar to that for integrin α5 and Ang1 in response to OGD/R, accompanied by increased activation of Tie2 and its downstream effectors focal adhesion kinase (FAK) and Akt. Knockdown of α5 integrin markedly suppressed OGD/R-induced Tie2 receptor activation in BECs, while in contrast, priming BECs with Ang1 promoted the expression of α5 integrin as well as the Tie2 downstream transcription factor Ets-1 in OGD-treated BECs. In line with this, Ets-1 knockdown significantly attenuated Ang1- mediated upregulation of α5 integrin. Functionally, Ang1 induced cell migration and tube formation of BECs after OGD, but this effect was inhibited by diminishment of the levels of α5 integrin in BECs. Taken together, our data indicate that the Ang1/Tie2 system cross-talks with integrin α5β1 in BECs after CI, which may contribute to the endogenous angiogenic vascular protective response following CI.
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