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- 저자 : Longjiang Gu (검색결과 1 건)
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Comparative Study of the marR Genes within the Family Enterobacteriaceae
Dan Wang,Changjiang Guo,Longjiang Gu,Xiaohui Zhang 한국미생물학회 2014 The journal of microbiology Vol.52 No.6
marR genes are members of an ancient family originallyidentified in Escherichia coli. This family is widely distributedin archaea and bacteria. Homologues of this family have aconserved winged helix fold. MarR proteins are involved innon-specific resistance systems conferring resistance to multipleantibiotics. Extensive studies have shown the importanceof MarR proteins in physiology and pathogenicity inEnterobacteria, but little is known about their origin or evolution. In this study, all the marR genes in 43 enterobacterialgenomes representing 14 genera were identified, and the phylogeneticrelationships and genetic parameters were analyzed. Several major findings were made. Three conserved marRgenes originated earlier than Enterobacteriaceae and a genelossevent was found to have taken place in Yersinia pestisAntiqua. Three functional genes, rovA, hor, and slyA, werefound to be clear orthologs among Enterobacteriaceae. Thecopy number of marR genes in Enterobacteriaceae was foundto vary from 2 to 11. These marR genes exhibited a faster rateof nucleotide substitution than housekeeping genes did. Specifically, the regions of marR domain were found to besubject to strong purifying selection. The phylogenetic relationshipand genetic parameter analyses were consistentwith conservation and specificity of marR genes. These dualcharacters helped MarR to maintain a conserved bindingmotif and variable C-terminus, which are important to adaptiveresponses to a number of external stimuli in Enterobacteriaceae.
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