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Studies on structure and Color of the White Antberaea pernyi, Silkworm Cocoon
Ji Tao,Liu Hongde 한국생약학회 1995 Natural Product Sciences Vol.1 No.1
Traditional Antheraea pernyi silkworm cocoon is tawny color. The white Antheraea pernyi silkworm cocoons studied here by IR and UV are new breeds of recent breeding. We discovered that the main body of the first grade structure of silk protein in the new white is as same as the one in the traditional tawny Antheraea pernyi silkworm cocoon, yet there are small quantities of cross-linked polymer of gentisic acid and silk protein in the white silkworm cocoons. In spite of the least surviving quantity of the polymer, the white silkworm cocoons are most white and its white color is similar to white Bombyx mori silkworm cocoon.
The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence
Li, Xiaoman,Xu, Hongde,Xu, Chongan,Lin, Meina,Song, Xiaoyu,Yi, Fei,Feng, Yanling,Coughlan, Kathleen A.,Cho, William Chi-shing,Kim, Sang Soo,Cao, Liu MDPI 2013 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.14 No.2
<P>Senescent cells are relatively stable, lacking proliferation capacity yet retaining metabolic activity. In contrast, cancer cells are rather invasive and devastating, with uncontrolled proliferative capacity and resistance to cell death signals. Although tumorigenesis and cellular senescence are seemingly opposite pathological events, they are actually driven by a unified mechanism: DNA damage. Integrity of the DNA damage response (DDR) network can impose a tumorigenesis barrier by navigating abnormal cells to cellular senescence. Compromise of DDR, possibly due to the inactivation of DDR components, may prevent cellular senescence but at the expense of tumor formation. Here we provide an overview of the fundamental role of DDR in tumorigenesis and cellular senescence, under the light of the Yin-Yang concept of Chinese philosophy. Emphasis is placed on discussing DDR outcome in the light of <I>in vivo</I> models. This information is critical as it can help make better decisions for clinical treatments of cancer patients.</P>