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Ayesha Siddika,Tasnim Zahan,Lipy Khatun,Md. Rowshanul Habib,Md. Abdul Aziz,A. R. M. Tareq,Md. Habibur Rahman,Md. Rezaul Karim 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.9
This study was designed to evaluate the antioxidantactivity of methanol extract of Averrhoa carambollaLinn. leaves (MELA) using DPPH˙ and ABTS˙+ free radicalscavenging assays whereas its antineoplastic effectagainst Ehrlich ascites carcinoma (EAC) was assed usingviable cell count, life span, body weight gain and hematologicalparameters of experimental mice. Results showedthat rich phenolic and flavonoid content of MELA hadmoderate dose dependent free radical scavenging activity(IC50: 62.0 lg/mL for DPPH˙ and 6.0 lg/mL for ABTS˙+). In vivo antineoplastic assay, MELA significantly(P\0.05) decreased viable cells and body weight gain,increased the survival time and restored altered hematologicalprofiles of cancer cell bearing mice. Fluorescencemicroscopic view of EAC cells derived from MELA-treatedgroup showed apoptotic characteristics and this observationwas also supported by overexpression of proapoptoticgenes coding p53 and Bax proteins in treatedcancer cells. The anti-apoptotic genes coding Bcl-2 proteinwas also absent in treated EAC cells as compared with thecontrol. Moreover, phytochemical profiles of MELA asidentified by GC/MS analysis are also consistent with itsactivities.