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- 저자 : Liping Mo (검색결과 4 건)
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Peptidomics analysis of enzymatic hydrolysis beef
Dan Qin,Liping Wang,Rui Fang,Ziteng Yu,Li Mo,Min Liu 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.10
In this study, we investigated the changes in the composition of peptides during the digestion of tenderized beef treated with commercial proteinase K, flavourzyme, and bromelain. The degree of hydrolysis (DH) values before and after simulating gastric digestion were highest with proteinase K treatment. In the proteinase K-treated sample, the highest number of missing peptides was identified after gastrointestinal digestion. Additionally, the maximum number of new peptides was identified during gastric digestion. The flavourzyme is the only exopeptidase among the three enzymes, and the sample treated with it could produce more unique peptides after gastrointestinal digestion. Enzymatic tenderization altered the peptide composition and bioactivity of beef proteins during gastrointestinal digestion. The number of peptides, as well as unique peptides in the protease-treated sample, were more than those in control through gastric digestion. In contrast, the opposite was observed post gastrointestinal digestion.
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Yuwei Liu,Guipeng Chen,Liping Mo,Xinlin Qing 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Thanks to the favorable advantage of reduced magnetic components, single-inductor multi-output DC-DC converters are attractive in low-cost industrial applications. However, when the converters work in continuous conduction mode (CCM), a severe dynamic cross-regulation problem will occur due to the current multiplex of the same inductor. To solve this problem, an improved single-inputdual-output (SIDO) buck converter is proposed in this paper, which employs one coupled inductor with 1:1 turns ratio as a substitution for the inductor. In the proposed converter, the two output voltages can be controlled independently while the advantage of fewer magnetic cores is retained. Moreover, reduced number of semiconductor components is achieved, leading to a lower cost. Besides, because of the 1:1 turns ratio, the magnetizing current is also effectively decreased to the one output current rather than the sum of two output currents, which will reduce the volume of magnetic core.
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Peng Wang,Bo Yin,Liping Shan,Hui Zhang,Jun Cui,Mo Zhang,Yongsheng Song 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.12
Astrocyte elevated gene-1 (AEG-1) is a recently discov-ered oncogene that has been reported to be highly expressed in various types of malignant tumors, including renal cell carcinoma. However, the precise role of AEG-1 in renal cancer cell proliferation and apoptosis has not been clarified. In this study, we transfected the renal cancer cell line Caki-1 with a plasmid expressing AEG-1 short hairpin RNA (shRNA) and obtained cell colonies with stable knockdown of AEG-1. We found that AEG-1 down-regulation inhibited cell proliferation and colony formation and arrested cell cycle progression at the sub-G1 and G0/G1 phase. Western blot analysis indicated that the expression of proliferating cell nuclear antigen (PCNA), cyclin D1 and cyclin E were significantly reduced following AEG-1 down-regulation. In addition, AEG-1 knockdown led to the appearance of apop-totic bodies in renal cancer cells, and the ratio of apoptotic cells significantly increased. Expression of the anti-apoptotic factor Bcl-2 was dramatically reduced, whereas the pro-apoptotic factors Bax, caspase-3 and poly (ADP-ribose) polymerase (PARP) were significantly activated. Finally, AEG-1 knockdown in Caki-1 cells remarkably suppressed cell proliferation and enhanced cell apoptosis in response to 5-fluorouracil (5-FU) treatment, suggesting that AEG-1 inhibition sensitizes Caki-1 cells to 5-FU. Taken together, our data suggest that AEG-1 plays an important role in renal cancer formation and development and may be a potential target for future gene therapy for renal cell carcinoma.
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Wang, Peng,Yin, Bo,Shan, Liping,Zhang, Hui,Cui, Jun,Zhang, Mo,Song, Yongsheng Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.12
Astrocyte elevated gene-1 (AEG-1) is a recently discovered oncogene that has been reported to be highly expressed in various types of malignant tumors, including renal cell carcinoma. However, the precise role of AEG-1 in renal cancer cell proliferation and apoptosis has not been clarified. In this study, we transfected the renal cancer cell line Caki-1 with a plasmid expressing AEG-1 short hairpin RNA (shRNA) and obtained cell colonies with stable knockdown of AEG-1. We found that AEG-1 down-regulation inhibited cell proliferation and colony formation and arrested cell cycle progression at the sub-G1 and G0/G1 phase. Western blot analysis indicated that the expression of proliferating cell nuclear antigen (PCNA), cyclin D1 and cyclin E were significantly reduced following AEG-1 down-regulation. In addition, AEG-1 knockdown led to the appearance of apoptotic bodies in renal cancer cells, and the ratio of apoptotic cells significantly increased. Expression of the antiapoptotic factor Bcl-2 was dramatically reduced, whereas the pro-apoptotic factors Bax, caspase-3 and poly (ADPribose) polymerase (PARP) were significantly activated. Finally, AEG-1 knockdown in Caki-1 cells remarkably suppressed cell proliferation and enhanced cell apoptosis in response to 5-fluorouracil (5-FU) treatment, suggesting that AEG-1 inhibition sensitizes Caki-1 cells to 5-FU. Taken together, our data suggest that AEG-1 plays an important role in renal cancer formation and development and may be a potential target for future gene therapy for renal cell carcinoma.
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