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RISS 인기검색어
- 검색키워드
- 저자 : Linlin Zhong (검색결과 4 건)
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Zhong, Linlin,Samal, Monica,Yun, Kyusik Elsevier 2018 Materials chemistry and physics Vol.204 No.-
<P><B>Abstract</B></P> <P>In this study, we reported an optimized facile method to synthesize ZnO particles of three kinds of morphologies, flower-like, rod-like and sphere. Although ZnO grew along the a- and c-axes, however, the anisotropic crystal growth mechanism of ZnO particles was investigated by the ratio of precursor and temperature of the reaction. The characterizations of three ZnO particles were measured by Field-emission scanning electron microscopy, Fourier-transform infrared spectroscopy and X-ray diffraction. In addition, ZnO with three shapes was fixed on gold-printed circuit board to detect their electrochemistry property in a 3% H<SUB>2</SUB>O<SUB>2</SUB>/phosphate buffer, while ZnO/GO (graphene oxide) composite was obtained by organic linking which showed the different electrochemical results compare to that of ZnO. electron-transfer distance and speed have been changed between the products and support due to the combination of ZnO and GO. The exploration of ZnO of different shape and ZnO/GO composites on their features and properties would provide significant evidence for their application as sensors in extensive fields.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Three types of ZnO particles are synthesized successfully by facile method. </LI> <LI> The mechanism of ZnO growth in the aqueous solution is proposed. </LI> <LI> The ZnO particles were decorated on the surface of graphene oxide sheets. </LI> <LI> ZnO and ZnO/GO composites can be applied in analyzation of H<SUB>2</SUB>O<SUB>2</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Schematic of electrochemical reaction on ZnO and ZnO/GO composites modified Au-PCB electrode, respectively. Insert image is rod-like ZnO particles and rod-like ZnO/GO composites.</P> <P>[DISPLAY OMISSION]</P>
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Function identification of bovine Nramp1 promoter and intron 1
Hao, Linlin,Zhang, Libo,Li, Mingtang,Nan, Wang,Liu, Songcai,Zhong, Jifeng The Korean Society for Integrative Biology 2011 Animal cells and systems Vol.15 No.3
The Nramp1/Slc11a1 locus encodes a proton-coupled divalent cation transporter, expressed in late endosomes/lysosomes of macrophages, that constitutes a component of the innate immune response to combat intracellular pathogens and it was shown to play an important role in regulating inherent immunity. The previously identified Z-DNA forming polymorphic repeat(GT)n in the promoter region of the human Nramp1 gene does act as a functional polymorphism influencing gene expression. Research has shown that INF-${\gamma}$, TNF-${\alpha}$, IL-$1{\beta}$ and bacteria LPS increase the level of Nramp1 expression. However, the molecular mechanism for Nramp1 gene regulation is unclear. In this research, bovine Nramp1 5'-flanking region (-1748~+769) was cloned and analyzed by bioinformatics. Then to find the core promoter and the cis-acting elements, deletion analysis of promoter was performed using a set of luciferase reporter gene constructs containing successive deletions of the bovine Nramp1 5'-flanking regions. Promoter activity analysis by the dual luciferase reporter assay system showed that the core promoter of Nramp1 was located at +58~-89 bp. Some positive regulatory elements are located at -89~-205 bp and -278~-1495 bp. And the repressor elements were in region -205~-278 bp, intron1 and -1495~-1748 bp. LPS-responsive regions were located at -1495~-1748 bp and -278~-205 bp. The present study provides an initial effort to explore the molecular mechanism of transcriptional activation of the bovine Nramp1 gene and should facilitate further studies to decode the complex regulatory process and for molecular breeding for disease resistance in bovines.
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Huifang Liu,Linlin Zhong,윤규식,Monica Samal 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.1
In the field of nanotechnology, silver nanoparticles have been considered a promising antibacterial material for a century. The potential applications of graphene-based materials are increasingly recognized for their special physico-chemical and biological properties. In particular, graphene and graphene oxide as the foundation of nanocomposites have garnered much interest among researchers in many fields. In this review, we concentrate on different aspects of silver nanoparticle composites with graphene and graphene oxide, focusing on their synthesis methods, special characteristics, and antibacterial properties; we also briefly discuss limitations and future research.
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Liu, Huifang,Zhao, Fei,Jin, Choong Eun,Koo, Bonhan,Lee, Eun Yeong,Zhong, Linlin,Yun, Kyusik,Shin, Yong American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.8
<P>Nucleic acid-based diagnostics are widely used for clinical applications due to their powerful recognition of biomolecule properties. Isolation and purification of nucleic acids such as DNA and RNA in the diagnostic system have been severely hampered in point-of-care testing because of low recovery yields, degradation of nucleic acids due to the use of chaotropic detergent and high temperature, and the requirement of large instruments such as centrifuges and thermal controllers. Here, we report a novel large instrument- and detergent-free assay via binary nanomaterial for ultrasensitive nucleic acid isolation and detection from cells (eukaryotic and prokaryotic). This binary nanomaterial couples a zinc oxide nanomultigonal shuttle (ZnO NMS) for cell membrane rupture without detergent and temperature control and diatomaceous earth with dimethyl suberimidate complex (DDS) for the capture and isolation of nucleic acids (NA) from cells. The ZnO NMS was synthesized to a size of 500 nm to permit efficient cell lysis at room temperature within 2 min using the biological, chemical, and physical properties of the nanomaterial. By combining the ZnO NMS with the DDS and proteinase K, the nucleic acid extraction could be completed in 15 min with high quantity and quality. For bacterial cells, DNA isolation with the binary nanomaterial yielded 100 times more DNA, than a commercial spin column based reference kit, as determined by the NanoDrop spectrophotometer. We believe that this binary nanomaterial will be a useful tool for rapid and sensitive nucleic acid isolation and detection without large instruments and detergent in the field of molecular diagnostics.</P> [FIG OMISSION]</BR>
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