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        LB energy-saving high temperature shift catalyst and its adsorption thermodynamics

        Lingchao Wei,Fu’An Wang,Yi Liu,Yongli Chai 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.1

        This study prepared an LB energy-saving high temperature shift catalyst by optimizing its prepare parameters with artificial neural network, and measured its catalytic activities at various steam-gas ratios. It shows that the LB catalyst performs well at a lower steam-gas ratio. The chromatographic retention parameters of CO, CO2, and H2O on LB catalyst were experimentally determined by means of inverse gas chromatography (IGC). Adsorption enthalpies, Gibbs adsorption free energies and adsorption entropies of different gases were estimated by their retention volumes in infinite dilution region. The interaction parameters ( χ) between absorbate gases and LB catalyst were calculated according to Flory-Huggins theory, and were inversely linear with temperature. The thermodynamics mechanism of the adsorption process was discussed from the view of the microcosmic factors of molecular structure and thermodynamic properties.

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        Regulatory Mechanism of MicroRNA-145 in the Pathogenesis of Acute Aortic Dissection

        Tianbo Li,Chencheng Liu,Lingchao Liu,Han Xia,Yingbin Xiao,Xuefeng Wang,Yong Wang 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.4

        Purpose: Previous studies have confirmed that microRNAs play important roles in the pathogenesis of acute aortic dissection(AAD). Here, we aimed to explore the role of miR-145 and its regulatory mechanism in the pathogenesis of AAD. Materials and Methods: AAD tissue samples were harvested from patients with aortic dissection and normal donors. Rat aorticvascular smooth muscle cells (VSMCs) were transfected with miR-145 mimic/inhibitor or negative control mimic/inhibitor. Geneand protein expression was measured in human aortic dissection tissue specimens and VSMCs by qRT-PCR and Western blot. Luciferasereporter assay was applied to verify whether connective tissue growth factor (CTGF) was a direct target of miR-145 inVSMCs. Methyl thiazolyl tetrazolium assay was used to detect VSMC viability. Results: miR-145 expression was downregulated in aortic dissection tissues and was associated with the survival of patients withAAD. Overexpression of miR-145 promoted VSMC proliferation and inhibited cell apoptosis. Moreover, CTGF, which was increasedin aortic dissection tissues, was decreased by miR-145 mimic and increased by miR-145 inhibitor. Furthermore, CTGF wasconfirmed as a target of miR-145 and could reverse the promotion effect of miR-145 on the progression of AAD. Conclusion: miR-145 suppressed the progression of AAD by targeting CTGF, suggesting that a miR-145/CTGF axis may provide apotential therapeutic target for AAD.

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