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RISS 인기검색어
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- 저자 : Ling-Qiang (검색결과 61 건)
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Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors
Zhang, Ling-Qiang,Zhang, Xiu-De,Xu, Jia,Wan, Yong,Qu, Kai,Zhang, Jing-Yao,Wang, Zhi-Xin,Wei, Ji-Chao,Meng, Fan-Di,Tai, Ming-Hui,Zhou, Lei,Liu, Chang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.
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Fan, Yu-Ling,Fan, Bing-Yu,Li, Qiang,Di, Hai-Xiao,Meng, Xiang-Yu,Ling, Na Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18
Aims: To prepare 5-fluorouracil (5-Fu) nanoparticles with higher encapsulation efficiency and drug loading, and then investigate interaction with the SGC-7901 gastric cancer cell line. Materials and Methods: Prescription was optimized by orthogonal experiments, the encapsulation efficiency and loading capacity were tested by high-performance liquid chromatography, and inhibition of proliferation by 5-Fu nanoparticles and 5-Fu given to cells for 24, 48 and 72 hours was investigated by methyl thiazolyl tetrazolium assay (MTT). In addition, 5-Fu nanoparticles were labeled by fluorescein isothiocyanate (FITC), and absorption into cells was tested by flow cytometry. Results: The optimal conditions for preparation were concentrations of 5-Fu of 5mg/ml, of $CaCl_2$ of 60 mg/ml and of chitosan of 2 mg/ml. With a stirring speed of 1200rpm, encapsulation efficiency of 5-Fu nanoparticles was $55.4{\pm}1.10%$ and loading capacity was $4.22{\pm}0.14%$; gastric cancer cells were significantly inhibited by 5-Fu nanoparticles in a time and concentration dependent manner, and compared to 5-Fu with slower drug release, in a certain concentration range, inhibition with 5-Fu nanoparticles was stronger. 5-Fu nanoparticles were absorbed by the cells in line with the concentration. Conclusions: 5-Fu nanoparticles can inhibit growth of gastric cancer cells in vitro to a greater extent than with 5-Fu with good adsorption characteristics, supporting feasibility as a carrier.
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Rational finite element method for plane orthotropic elastic problems
Ling Mao,Weian Yao,Qiang Gao,Wanxie Zhong 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6
The rational finite element method is different from the standard finite element method, which is constructed using basic solutions of the governing differential equations as interpolation functions in the elements. Therefore, it is superior to the isoparametric approach because of its obvious physical meaning and accuracy; it has successfully been applied to the isotropic elasticity problem. In this paper, the formulation of rational finite elements for plane orthotropic elasticity problems is deduced. This method is formulated directly in the physical domain with full consideration of the requirements of the patch test. Based on the number of element nodes and the interpolation functions, different approaches are applied with complete polynomial interpolation functions. Then, two special stiffness matrixes of elements with four and five nodes are deduced as a representative application. In addition, some typical numerical examples are considered to evaluate the performance of the elements. The numerical results demonstrate that the present method has a high level of accuracy and is an effective technique for solving plane orthotropic elasticity problems.
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Ling-Zhu Chen,Gianluca Ranzi,Shou-Chao Jiang,Faham Tahmasebinia,Guo-Qiang Li 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.1
This paper describes an extensive experimental and numerical study conducted to evaluate the thermo-structural response of shear connectors embedded in composite slabs with steel sheeting parallel to the steel beam, with particular focus on opentrapezoidal profiles. For this purpose, eight push-out tests were carried out at different levels of temperature. A threedimensional finite element model was developed in Abaqus and its accuracy was validated against the experimental measurements collected as part of this study. The model was then used to perform a parametric study to gain insight into the structural response at different temperatures. The experimental and numerical results were then used to evaluate the accuracy of available European guidelines for predicting the capacity of shear connectors at elevated temperatures (when embedded in composite slabs with the profiled sheeting parallel to the steel beam). Finally, a new design equation was proposed to calculate the degradation factor defining the resistance of shear connectors for different levels of temperature
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Improved Cascade Control System for a Class of Unstable Processes with Time Delay
Cheng-qiang Yin,Hong-tao Wang,Qun Sun,Ling Zhao 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.1
An improved cascade control scheme is proposed based on modified Smith predictor for controllinga class of unstable processes with time delay. The proposed control structure consist three controllers of whichthe secondary loop has one controller and the primary loop has two controllers. The secondary loop controller isdesigned according to Internal Model Control (IMC) principles. The primary loop set point tracking controller anddisturbance rejection controller are designed using the same procedure based on modified Smith predictor controlstructure. An analytical method on the basis of the Internal Model Control design principle is adopted for the twocontrollers which reduces complexity in design. The two controllers in primary loop are designed as proportional,integral and derivative (PID) controller cascaded with a lead-lag filter. Moreover, suitable values are recommendedfor the three controllers based on extensive simulations. Simulations studies are carried out to demonstrate theeffectiveness of the proposed method.
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Wang, Ling,Wang, Qiang,Li, He-Lian,Han, Li-Ying Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Aim and Background: Cervical cancer remains the third most common cancer in women globally after breast and colorectal cancer. Well-characterized biomarkers are necessary for early diagnosis and to predict metastatic progression and effective therapy. MiRNAs can regulate gene expression, cell growth, differentiation and apoptosis by targeting mRNAs for translational repression or degradation in tumor cells. The present study was conducted to assess expression of miR93, miR200a, RECK, MMP2, MMP9 in invasive cervical carcinoma, and analyze their clinical significance. Method: A total of 116 patients with invasive cervical carcinoma and 100 patients undergoing hysterectomy for benign lesions were retrospectively examined. Quantitative real-time PCR was performed to determine expression of miR93 and miR200a while RECK, MMP2, MMP9 and MVD were assessed by immunohistochemical staining. Results: Cervical carcinoma patients demonstrated up-regulation of miR-93, miR-200a, MMP2 and MMP9, with down-regulation of RECK as compared to benign lesion tissues. RECK was significantly inversely related to invasion and lymphatic metastasis. The 5-year survival rate for patients with strong RECK expression was significantly higher than that with weakly expressing tumors. Conclusion: MiR-93 and miR-200a are associated with metastasis and invasion of cervical carcinoma. Thus together with RECK they are potential prognostic markers for cervical carcinoma. RECK cooperating with MMP2, MMP9 expression is a significant prognostic factor correlated with long-term survival for patients with invasive cervical carcinoma.
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Rational finite element method for plane orthotropic elastic problems
Mao, Ling,Yao, Weian,Gao, Qiang,Zhong, Wanxie Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.51 No.6
The rational finite element method is different from the standard finite element method, which is constructed using basic solutions of the governing differential equations as interpolation functions in the elements. Therefore, it is superior to the isoparametric approach because of its obvious physical meaning and accuracy; it has successfully been applied to the isotropic elasticity problem. In this paper, the formulation of rational finite elements for plane orthotropic elasticity problems is deduced. This method is formulated directly in the physical domain with full consideration of the requirements of the patch test. Based on the number of element nodes and the interpolation functions, different approaches are applied with complete polynomial interpolation functions. Then, two special stiffness matrixes of elements with four and five nodes are deduced as a representative application. In addition, some typical numerical examples are considered to evaluate the performance of the elements. The numerical results demonstrate that the present method has a high level of accuracy and is an effective technique for solving plane orthotropic elasticity problems.
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Du, Qiang,Jiang, Lei,Wang, Xiao-Qian,Pan, Wei,She, Fei-Fei,Chen, Yan-Ling Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Gallbladder carcinoma (GBC) is the most common carcinoma of the biliary system. Among its research models, orthotopic xenograft models, important research tools, have been rarely reported in the literature however. Aim: To explore establishment of an orthotopic xenograft model and to evaluate the advantage and disadvantage as compared with other models. Materials and Methods: Subcutaneous xenograft and orthotopic xenograft models of gallbladder carcinoma in nude mice were established and compared with human gallbladder carcinomas. Results: For the orthotopic xenograft model and clinical gallbladder carcinomas, the lymph node metastatic rates were 69.2% and 53.3% (p>0.05); ascites generation rates, 38.5% and 11.7%(p<0.05); liver invasive rates, 100% and 61.7%(p<0.05); and lymphatic vessel densities (LVD), $10.4{\pm}3.02$ and $8.77{\pm}2.92$ (p>0.05), respectively. In the subcutaneous xenograft model, no evidence of ascites generation, lymph node metastasis and liver metastasis were found, and its LVD was lower ($4.56{\pm}1.53$, p<0.05). Conclusions: Compared with the subcutaneous xenograft model, the orthotopic xenograft model better simulates clinical gallbladder carcinoma in terms of metastasis and invasion, which may be attributed to the difference in microenvironment and LVD.
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