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Xia, Likai,Lee, Yong Rok WILEY‐VCH Verlag 2014 EUROPEAN JOURNAL OF ORGANIC CHEMISTRY Vol.2014 No.16
<P><B>Abstract</B></P><P>A novel method for the Ru<SUP>II</SUP>‐catalyzed regioselective synthesis of highly functionalized furans from readily available cyclic and acyclic diazodicarbonyl compounds and terminal alkynes is described. The devised protocol offers a straightforward means to the construction of a variety of diverse furan derivatives through powerful cascade processes, including the formation of ruthenium carbenoid, cyclopropenation, ring‐opening metathesis, and cyclization.</P>
Xia, Likai,Lee, Yong Rok The Royal Society of Chemistry 2013 Organic & Biomolecular Chemistry Vol.11 No.32
<P>We describe an efficient one-step synthesis of pyrrolo[3,4-<I>c</I>]quinolinedione derivatives using ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. It is the first direct conversion of isatins to pyrrolo[3,4-<I>c</I>]quinolinedione derivatives <I>via</I> C–N bond cleavage and isatin ring expansion. Furthermore, this reaction provides a one-step synthetic route for the production of biologically interesting complex molecules that are generally prepared using multi-step reactions.</P> <P>Graphic Abstract</P><P>An efficient one-step synthesis of a variety of pyrrolo[3,4-<I>c</I>]quinolinedione derivatives under mild conditions has been developed using the ethylenediamine diacetate (EDDA)-catalyzed cascade reactions of isatins and β-ketoamides. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3ob40791h'> </P>
Likai Xia,이용록 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
This paper describes efficient synthetic approaches for isolating biologically interesting natural pyranochalcones and their unnatural derivatives from Mallotus Philippensis. The key strategies involve ethylenediamine diacetate-catalyzed benzopyran formation reactions and base-catalyzed aldol reactions.
Xia, Likai,Lee, Yong Rok The Royal Society of Chemistry 2013 Organic & biomolecular chemistry Vol.11 No.36
<P>A novel approach was developed for the synthesis of diverse dihydronaphtho[1,2-<I>b</I>]furans from 1,4-naphthoquinones and olefins in the presence of ceric ammonium nitrate. This reaction provides a rapid route for the synthesis of a variety of dihydronaphtho[1,2-<I>b</I>]furans and naphtho[1,2-<I>b</I>]furans bearing different substituents. This methodology was also used to synthesize the biologically important natural product furomollugin in only 2 steps.</P> <P>Graphic Abstract</P><P>A novel approach was developed for the synthesis of diverse dihydronaphtho[1,2-<I>b</I>]furans from 1,4-naphthoquinones and olefins in the presence of ceric ammonium nitrate. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3ob40977e'> </P>
Likai Xia,Manchala Narasimhulu,Xin Li,심재진,이용록 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.3
This paper describes a new synthetic approach for biologically interesting geranylated acetophenones. The first total syntheses of 1-(5-geranyloxy-7-hydroxy-2,2-dimethyl-2H-chromen-8-yl)ethanone and 1-[5-geranyloxy-7-hydroxy-2- methyl-2-(4-methylpent-3-enyl)-2H-chromen-8-yl]ethanone, isolated from Melicope semecarpifolia, were carried out starting from commercially available 2,4,6-trihydroxyacetophenone.
New Synthetic Approaches to Naturally Occurring and Unnatural Pyranoflavones
Xia, Likai,Rok ,Lee, Yong WILEY‐VCH Verlag 2013 Helvetica chimica acta Vol.96 No.4
<P><B>Abstract</B></P><P>Total synthesis of biologically interesting natural and unnatural pyranoflavones has been accomplished starting from readily available 2,4‐dihydroxyacetophenone or 2,4‐dihydroxy‐6‐methoxyacetophenone in three steps, <I>i.e.</I>, benzopyran formation, condensation, and cyclization reaction.</P>
Xia, Likai,Magar, Krishna Bahadur Somai,Lee, Yong Rok ESCOM Science Publishers 2015 Molecular diversity Vol.19 No.1
<P>A new phosphine-catalyzed [3+2] annulation reaction between activated 1,4-naphthoquinones and acetylenecarboxylates is described. This reaction provides a facile and efficient route to a variety of biologically promising and novel naphtho[1,2-]furans. This devised method provides a first example for the synthesis of diverse naphtho[1,2-]furan derivatives from 1,4-naphthoquinones via phosphine-catalyzed [3+2] annulation. A variety of novel naphtho[1,2-]furans were synthesized via the phosphine-catalyzed [3+2] annulation of activated 1,4-naphthoquinones and electron-deficient acetylenecarboxylates. In some reactions, both furannulation adducts and reductive/nucleophilic conjugate addition products were produced.</P>