T-SPOT.TB for Detection of Tuberculosis Infection among Hematological Malignancy Patients and Hematopoietic Stem Cell Transplant Recipients

Qin, Li-Li,Wang, Qin-Rong,Wang, Qian,Yao, Hong,Wen, Li-Jun,Wu, Li-Li,Ping, Na-Na,Xie, Jun-Dan,Chen, Mei-Yu,Chen, Su-Ning Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

The diagnosis of latent Mycobacterium tuberculosis infection (LTBI) is recommended in hematological malignancy patients and before hematopoietic stem cell transplantation (Guidelines for the prevention and management of infectious complications of solid organ transplantation, 2004). Compared to traditional methods such as tuberculin skin test (TST), T-SPOT.TB has been shown to be more specific. In the present study we enrolled 536 patients for whom T-SPOT.TB was performed, among which 295 patients also received the TST test. The agreement (79%) between T-SPOT.TB and TST was poor (x=0.274, P<0.001). The patients with positive T-SPOT.TB results numbered 62 (11.6%), in which only 20 (48.8%) of the 41 receiving the TST test had positive results. A majority of the patients with T-SPOT.TB positive results had some other evidence ofTB, such as TB history, clinical symptoms and an abnormal chest CT scan. Active TB was found in 9 patients, in which 2 had negative TST results. We followed up the patients and no one developed active TB. Our study suggested that the T-SPOT.TB may be more useful for screening LTBI and active TB in hematological malignancy patients and hematopoietic stem cell transplant recipients than the TST test.

The Application of welding numerical simulation on two typical welded structures in railway vehicles

Ya-na, Li,Cheng-tao, Li,Bin, Yuan,Su-ming, Xie Techno-Press 2012 Interaction and multiscale mechanics Vol.5 No.2

The thin-plate structure and the box-beam structure are two typical welded structures in railway vehicles. Because of their structure complexity, bigger size and multi-seams, welding residual distortion which occur in welding process bring unfavorable effect on the quality of welding products manufacturing and service. As a result, welding distortion forecasting and control become an important and urgent research topic in railway vehicles. In this paper, three different numerical methods are presented corresponding to three typical types of welded structures of railway vehicles and welding deformation are simulated. Consistence of numerical results and experimental data proves the correctness of models and feasibility of simulation methods.

Application of modified graphite felt as electrode material: a review

Yang Su,Na Chen,Hai‑lin Ren,Cheng‑wei Li,Li‑li Guo,Zhen Li,Xiao‑min Wang 한국탄소학회 2023 Carbon Letters Vol.33 No.1

Graphite felt is a felt-like porous material made of high-temperature carbonized polymers. It is widely used in electrode materials because of its good temperature resistance, corrosion resistance, large surface area and excellent electrical conductivity. In this paper, the surface functional group modification is of graphite felt electrodes (mainly nitrogen doping modification, nitrogen–sulfur or nitrogen–boron co-doping modification) and surface catalytic modification (metal/ion surface modification and metal oxide surface modification as Main). There are two main methods and research progresses to improve the performance of graphite felt electrodes, and the comprehensive performance of surface functional group-modified graphite felt electrodes and surface catalytically modified graphite felt electrodes are compared respectively. The results show that both surface functional group modification and surface catalytic modification can improve the comprehensive performance of graphite felt electrodes. In this paper, the future development direction of graphite felt activation modification is also prospected.

Early Growth Response Protein-1 Involves in Transforming Growth factor-β1 Induced Epithelial-Mesenchymal Transition and Inhibits Migration of Non-Small-Cell Lung Cancer Cells

Shan, Li-Na,Song, Yong-Gui,Su, Dan,Liu, Ya-Li,Shi, Xian-Bao,Lu, Si-Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

The zinc finger transcription factor EGR 1 has a role in controlling synaptic plasticity, wound repair, female reproductive capacity, inflammation, growth control, apoptosis and tumor progression. Recent studies mainly focused on its role in growth control and apoptosis, however, little is known about its role in epithelial-mesenchymal transition (EMT). Here, we aim to explore whether EGR 1 is involved in TGF-${\beta}1$-induced EMT in non-smallcell lung cancer cells. Transforming growth factor (TGF)-${\beta}1$ was utilized to induce EMT in this study. Western blotting, RT-PCR, and transwell chambers were used to identify phenotype changes. Western blotting was also used to observe changes of the expression of EGR 1. The lentivirus-mediated EGR 1 vector was used to increase EGR 1 expression. We investigated the change of migration to evaluate the effect of EGR 1 on non-small-cell lung cancer cells migration by transwell chambers. After stimulating with TGF-${\beta}1$, almost all A549 cells and Luca 1 cells (Non-small-cell lung cancer primary cells) changed to mesenchymal phenotype and acquired more migration capabilities. These cells also had lower EGR 1 protein expression. Overexpression of EGR 1 gene with EGR 1 vector could decrease tumor cell migration capabilities significantly after adding TGF-${\beta}1$. These data s howed an important role of EGR 1 in the EMT of non-small-cell lung cancer cells, as well as migration.

Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

Cui, Xiao-Bin,Peng, Hao,Li, Su,Li, Ting-Ting,Liu, Chun-Xia,Zhang, Shu-Mao,Jin, Ting-Ting,Hu, Jian-Ming,Jiang, Jin-Fang,Liang, Wei-Hua,Li, Na,Li, Li,Chen, Yun-Zhao,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis. Materials and Methods: Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA. Results: Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer. Conclusions: Our metaanalysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.

Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression

Su Na,Liu Li,He Shan,Zeng Linghai 한국유전학회 2021 Genes & Genomics Vol.43 No.8

Background Circular RNAs (circRNAs) play important roles in the progression of various cancers, including breast cancer (BC). However, the role of circ_0001666 in BC remains unclear. Objective To explore the role of circ_0001666 in the progression of BC and reveal its potential molecular mechanism. Methods Real-time polymerase chain reaction was conducted to determine the expression of circ_0001666, miR-620 and with-no-lysine kinase 2 (WNK2). Cell counting kit 8 assay, fow cytometry and transwell assay were used to measure cell proliferation, apoptosis, migration and invasion. Western blot was utilized to examine the level of protein. Dual-luciferase reporter assay and RNA immunoprecipitation assay were used to verify the interaction between miR-620 and circ_0001666 or WNK2. Mice xenotransplantation models were built to explore the efect of circ_0001666 on BC tumor growth in vivo. Results Circ_0001666 was downregulated in BC tumor tissues and cells. Overexpressed circ_0001666 inhibited the proliferation, migration, invasion, while promoted apoptosis and tumor growth of BC in vitro or in vivo. Furthermore, circ_0001666 could serve as a sponge of miR-620. MiR-620 inhibitor hindered BC cell progression, which was similar to the efect of circ_0001666 overexpression. WNK2 was a target of miR-620, and circ_0001666 could sponge miR-620 to positive regulate WNK2. The knockdown of WNK2 reversed the efect of circ_0001666 overexpression on BC progression. Conclusion Circ_0001666 hindered the progression of BC via miR-620/WNK2 axis.

Inductively coupled plasma reactive ion etching of titanium nitride thin films in a Cl₂/Ar plasma

Su Ryun Min,Han Na Cho,Yue Long Li,Sung Keun Lim,Seung Pil Choi,Chee Won Chung 한국공업화학회 2008 Journal of Industrial and Engineering Chemistry Vol.14 No.3

An inductively coupled plasma reactive ion etching of TiN thin films was carried out using a Cl₂/Ar gas chemistry. The etch characteristics such as the etch rate and etch profile were investigated by varying gas concentration and etch parameters including coil radio frequency (rf) power, dc-bias voltage and gas pressure. As the Cl₂ concentration increased, the etch rates of TiN thin films increased while the sidewall slopes of the etched films became slanted without the redeposition or etch residues. With increasing coil rf power and dc-bias voltage, the etch rates increased and etch slope became steep. Gas pressure has a little effect on etch rate and better etch profile was obtained at low gas pressure. Finally, highly anisotropic etching of TiN thin a film using a photoresist mask was achieved at the optimized etch condition.

농업산출의 추계와 분석(1955∼2012년)

황수철 ( Su Chul Hwang ),유리나 ( Li Na Yoo ),유영봉 ( Young Bong Yu ) 한국식품유통학회 2014 食品流通硏究 Vol.31 No.4

The purpose of this study is to examine the growth of Korean agriculture for the period 1955∼2012 by estimating time-series data of total agricultural production. The emphasis is on arranging the reliable time-series data of output for closer analysis by enlarging the scope of its measurement up to 89 products. The results shows that the average growth rate of total agricultural production during the period is 2.3%. Furthermore it shows a significant difference in sectoral growth between crops and livestock. In order to review the result, comparative analysis on total output of Korean agricultural sector is conducted with other two official data.

텍스트마이닝 기법을 이용한 국내 농식품유통 연구동향 분석

유리나(Li-Na Yoo),황수철(Su-Chul Hwang) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.10

이 연구는 1984~2015년간 국내 농식품 유통분야 연구동향을 파악하기 위해 텍스트마이닝 기법을 이용한 분석결과이다. 텍스트마이닝은 빅데이터 분석방법의 일환으로, 많은 정보를 객관적으로 처리하여 연구주제 분류와 트렌드 분석에 이용할 수 있다. 실제분석에는 빈도분석, 토픽분석, 연관성분석을 수행하였다. 자료는 농업부문 4개 학술지 수록논문과 연구보고서 중 농식품 유통 관련 연구 제목를 이용하였다. 그 결과, 농식품 유통분야의 논문 1,126건은 6개 주제로 분류되었다. 2000년대를 기점으로 이전에는 도매와 산지연구가 활발했던 반면 이후에는 소비, 식품, 수출입 연구가 활발한 것으로 나타났다. 또한 로컬푸드와 학교급식 영역의 연구가 증가했다. 농산물 수급연구는 정책 연구보고서에서만 주기적으로 이루어졌으며, 학술논문에서는 2000년대 이후 관심주제에서 멀어지는 경향을 보였다. 2010년대 이후로는 특히 소비연구가 주류를 이루었고, 크게 소비트렌드와 소비자 행동에 관한 다양한 연구가 이루어졌다. 이 결과를 바탕으로 더 정확한 연구동향 분석을 하기위해서는, 정밀한 주제 분류기법으로 방법론을 보완하고 이용 자료를 키워드와 논문초록으로 확대함으로써 구체적인 결과를 도출해야 할 것이다. This study analyzed trends in agricultural and food marketing studies from 1984 to 2015 using text-mining techniques. Text-mining is a part of Big-data analysis, which is an effective tool to objectively process large amounts of information based on categorization and trend analysis. In the present study, frequency analysis, topic analysis and association rules were conducted. Titles of agricultural and food marketing studies in four journals and reports were used for placing the analysis. The results showed that 1,126 total theses related to agricultural and food marketing could be categorized into six subjects. There were significant changes in research trends before and after the 2000s. While research before 2000s focused on farm and wholesale level marketing, research after the 2000s mainly covered consumption, (processed)food, exports and imports. Local food and school meals are new subjects that are increasingly being studied. Issues regarding agricultural supply and demand were the only subjects investigated in policy research studies. Interest in agricultural supply and demand was lost after the 2000s. A number of studies after the 2010s analyzed consumption, primarily consumption trends and consumer behavior.

한국농업의 총요소생산성 추계와 분석(1955~2012년)

황수철 ( Su Chul Hwang ),유리나 ( Li Na Yoo ) 한국축산경영학회 2014 농업경영정책연구 Vol.41 No.4

This study estimates Total Factor Productivity in Korean Agriculture for the period 1955~2012 and analyzes productivity changes by employing Tornqvist index method. The empirical findings of the analysis are summarized as follow. During the past 57 years from 1955 to 2012, total agricultural output has increased by 2.6 percent per year. The annual average growth rate of total agricultural input over the period is 1.4 percent. Consequently total factor productivity (TFP) accounts for 46 percent of the growth of production. Total agricultural output and input have increased rapidly until the early 1990s, but both have declined since then. Over the whole period of this study, the pattern of productivity change is noticeable. The drivers of agricultural growth has moved from inputs to productivity. Thus, the 70 percent of agricultural output growth until the early 1990s accounted for an increase of agricultural input, and hereafter agricultural growth is explained entirely due to the productivity growth.