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Fat Embolism Syndrome - Three Case Reports and Review of the Literature
( Leonidas Grigorakos ),( Ioannis Nikolopoulos ),( Stamatina Stratouli ),( Anastasia Alexopoulou ),( Eleftherios Nikolaidis ),( Eleftherios Fotiou ),( Daria Lazarescu ),( Ioannis Alamanos ) 대한외상학회 2017 大韓外傷學會誌 Vol.30 No.3
The fat embolism syndrome (FES) represents a condition, usually with traumatic etiology, which may pose challenges to diagnosis while its treatment usually requires supportive measures in the intensive care units (ICUs). The clinical criteria, including respiratory and cerebral dysfunction and a petechial rash, along with imaging studies help in diagnosis. Here we present three case reports of young male who developed FES and were admitted to our ICUs after long bones fractures emerging after vehicle crashes and we briefly review FES literature. All patients' treatment was directed towards: 1) the restoration of circulating volume with fresh blood and/or plasma; 2) the correction of acidosis; and 3) immobilization of the affected part. All patients recovered and were released to the orthopedic wards. The incidence of cases of patients with FES admitted in our ICUs records a significant decrease. This may be explained in terms effective infrastructure reforms in Greece which brought about significant improvement in early prevention and management.
Evaluation of static response in stress-ribbon concrete pedestrian bridges
Leonidas T. Stavridis 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.2
An analytical method is proposed for the evaluation of the static response of a prestressedribbon concrete pedestrian bridge, which may also be applied for the roofing of large areas. On the basis of an established analogy with a suspension bridge system, a procedure is presented for the prestressedribbon direct analysis, leading to the introduction of two dimensionless parameters as governing factors of the design, namely the thinness and the prestressing steel ratio. The exposed procedure, applied by a simple computer program, allows a quick evaluation of the response and permits the investigation of the influence of the aforementioned parameters on it, by means of comprehensive diagrams. The presented diagrams may be directly used for the preliminary design of a pedestrian bridge of this type, for the whole practical range of span lengths. A design example is also included, showing the applicability of the proposed procedure.
A simplified analysis of the behavior of suspension bridges under live load
Leonidas T. Stavridis 국제구조공학회 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.5
Having established the initial geometry and cable force of a typical three span suspension bridge under permanent load, the additional maximum response of the cable and the stiffening girder due to live load are determined, by means of an analytic procedure, considering the girder first hinged at its ends and then continuous through the main towers. The problem of interaction between the cable and the stiffening girder is examined taking under due consideration the second order effects, whereby, through the analogy to a fictitious tensioned beam under transverse load, a closed –form solution is achieved by means of a simple quadratic equation. It is found that the behavior of the whole system is governed by five simple dimensionless parameters which enable a quick determination of all the relevant design magnitudes of the bridge. Moreover, by introducing these parameters, a set of diagrams is presented, which enable the estimation of the influence of the geometric and loading data on the response and permit its immediate evaluation for preliminary design purposes.
A simplified analysis of the behavior of suspension bridges under live load
Stavridis, Leonidas T. Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.5
Having established the initial geometry and cable force of a typical three span suspension bridge under permanent load, the additional maximum response of the cable and the stiffening girder due to live load are determined, by means of an analytic procedure, considering the girder first hinged at its ends and then continuous through the main towers. The problem of interaction between the cable and the stiffening girder is examined taking under due consideration the second order effects, whereby, through the analogy to a fictitious tensioned beam under transverse load, a closed -form solution is achieved by means of a simple quadratic equation. It is found that the behavior of the whole system is governed by five simple dimensionless parameters which enable a quick determination of all the relevant design magnitudes of the bridge. Moreover, by introducing these parameters, a set of diagrams is presented, which enable the estimation of the influence of the geometric and loading data on the response and permit its immediate evaluation for preliminary design purposes.
Evaluation of static response in stress-ribbon concrete pedestrian bridges
Stavridis, Leonidas T. Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.2
An analytical method is proposed for the evaluation of the static response of a prestresse-dribbon concrete pedestrian bridge, which may also be applied for the roofing of large areas. On the basis of an established analogy with a suspension bridge system, a procedure is presented for the prestresse-dribbon direct analysis, leading to the introduction of two dimensionless parameters as governing factors of the design, namely the thinness and the prestressing steel ratio. The exposed procedure, applied by a simple computer program, allows a quick evaluation of the response and permits the investigation of the influence of the aforementioned parameters on it, by means of comprehensive diagrams. The presented diagrams may be directly used for the preliminary design of a pedestrian bridge of this type, for the whole practical range of span lengths. A design example is also included, showing the applicability of the proposed procedure.
18F-FDG PET/CT Imaging of Pulmonary Mucinous Cystadenocarcinoma with Signet Ring Cells
Alexandros Kalkanis,Leonidas Palaiodimos,Ifigeneia Klinaki,Dimitrios Karantanis,Dimitrios Kalkanis 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.3
A 63-year-old male with a recently diagnosed right lung lesion was referred for staging. F-FDG PET/CT scan revealed a hypodense, cystic-like mass in the right upper lung lobe, which demonstrated low, diffuse 18FFDG uptake, likely due to the presence of mucus, as well as intensely hypermetabolic right hilar and right paratracheal lymph nodes. Transbronchial biopsy revealed a primary pulmonary mucinous cystadenocarcinoma with the presence of signet ring cell carcinoma, a co-existence of two rare variants of lung adenocarcinoma. This case report demonstrates the metabolic phenotype along with the radiographic characteristics of this rare tumor and its metastases.
Mechanisms of Type-I Interferon Signal Transduction
Uddin, Shahab,Platanias, Leonidas C. Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.6
Interferons regulate a number of biological functions including control of cell proliferation, generation of antiviral activities and immumodulation in human cells. Studies by several investigators have identified a number of cellular signaling cascades that are activated during engagement of interferon receptors. The activation of multiple signaling cascades by the interferon receptors appears to be critical for the generation of interferon mediated biological functions and immune surveillance. The present review summarizes the existing knowledge on the multiple signaling cascades activated by Type I interferons. Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed.