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RISS 인기검색어
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- 저자 : Lee W. Riley (검색결과 4 건)
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Kim, H.,Riley, T. V.,Kim, M.,Kim, C. K.,Yong, D.,Lee, K.,Chong, Y.,Park, J.-W. American Society for Microbiology 2008 Journal of clinical microbiology Vol.46 No.3
<P>Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A(-) B(+)). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A(-) B(+) strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.</P>
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Sulfolipid Accumulation in Mycobacterium tuberculosis Disrupted in the mce2 Operon
Olivera Marjanovic,Anthony T. Iavarone,Lee W. Riley 한국미생물학회 2011 The journal of microbiology Vol.49 No.3
Mycobacterium tuberculosis, the causative agent of tuberculosis, has a lipid-rich cell wall that serves as an effective barrier against drugs and toxic host cell products, which may contribute to the organism’s persistence in a host. M. tuberculosis contains four homologous operons called mce (mce1-4) that encode putative ABC transporters involved in lipid importation across the cell wall. Here, we analyzed the lipid composition of M. tuberculosis disrupted in the mce2 operon. High resolution mass spectrometric and thin layer chromatographic analyses of the mutant’s cell wall lipid extracts showed accumulation of SL-1 and SL1278 molecules. Radiographic quantitative analysis and densitometry revealed 2.9, 3.9 and 9.8-fold greater amount of [^(35)S]SL-1 in the mce2 operon mutant compared to the wild type M. tuberculosis during the early/mid logarithmic,late logarithmic and stationary phase of growth in liquid broth, respectively. The amount of [^(35)S] SL1278in the mutant also increased progressively over the same growth phases. The expression of the mce2 operon genes in the wild type strain progressively increased from the logarithmic to the stationary phase of bacterial growth in vitro, which inversely correlated with the proportion of radiolabel incorporation into SL-1 and SL1278 at these phases. Since the mce2 operon is regulated in wild type M. tuberculosis, its cell wall may undergo changes in SL-1 and SL1278 contents during a natural course of infection and this may serve as an important adaptive strategy for M. tuberculosis to maintain persistence in a host.
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지르코니아 분말의 치밀화와 소결거동 : II. 소결거동
박홍채,김겸,김영우,이윤복,오기동,Park, H.C.,Kim, K.,Kim, Y.W.,Lee, Y.B.,Oh, K.D.,Riley, Frank L. 한국세라믹학회 1993 한국세라믹학회지 Vol.30 No.6
Sintering behaviour of zirconia powders prepared by different processing treatment was discussed. About >99% densities of theoretical were obtaiend on sintering at 140$0^{\circ}C$ for 2h in case of 300MPa uniaxially cold-pressed compact. But the lower densities were obtained on sintering above this temperature due to abnormal grain growth enabling the tetragonal to monoclinic phase transformation during cooling resulted in microcracks. All kinds of different dried powders exhibited nearly the same shrinkage behaviour with end-point shrinkage between 19 and 20%, and had maximum shrinkage rate (0.99~1.27%/min) around 120$0^{\circ}C$. During whole sintering process densification was mainly governed by grain growth and rearrangement of agglomerates. Heterogeneous abnormal grain growth and abrupt decrease in shrinkage were observed when continuous interagglomerate pore collapsed into isolated pores.
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Sally A. Cantrell,Michael D. Leavell,Olivera Marjanovic,Anthony T. Iavarone,Julie A. Leary,Lee W. Riley 한국미생물학회 2013 The journal of microbiology Vol.51 No.5
The lipid-rich cell wall of Mycobacterium tuberculosis, the agent of tuberculosis, serves as an effective barrier against many chemotherapeutic agents and toxic host cell effector molecules, and it may contribute to the mechanism of persistence. Mycobacterium tuberculosis strains mutated in a 13-gene operon called mce1, which encodes a putative ABC lipid transporter, induce aberrant granulomatous response in mouse lungs. Because of the postulated role of the mce1 operon in lipid importation, we compared the cell wall lipid composition of wild type and mce1 operon mutant M. tuberculosis H37Rv strains. High resolution mass spectrometric analyses of the mce1 mutant lipid extracts showed unbound mycolic acids to accumulate in the cell wall. Quantitative analysis revealed a 10.7 fold greater amount of free mycolates in the mutant compared to that of the wild type strain. The free mycolates were comprised of alpha, methoxy and keto mycolates in the ratio 1:0.9:0.6, respectively. Since the mce1 operon is regulated in vivo, the free mycolates that accumulate during infection may serve as a barrier for M. tuberculosis against toxic products and contribute to the pathogen’s persistence.
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